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Chronic relapsing inflammatory optic neuropathy

MedGen UID:
1798657
Concept ID:
C5567234
Disease or Syndrome
Synonyms: Chronic recurrent isolated optic neuritis; chronic recurrent isolated optic neuritis; chronic relapsing inflammatory optic neuropathy; CRION; CRION - chronic relapsing inflammatory optic neuropathy
SNOMED CT: CRION - chronic relapsing inflammatory optic neuropathy (1169360001); Chronic relapsing inflammatory optic neuropathy (1169360001); Chronic recurrent isolated optic neuritis (1169360001)
 
Monarch Initiative: MONDO:0044687
Orphanet: ORPHA499085

Definition

A rare inflammatory optic neuropathy with characteristics of severe and persistent pain followed by subacute visual loss, a relapsing-remitting course and steroid-dependence. Involvement of both optic nerves is common and is usually sequential. Serum antibodies against aquaporin 4 are absent in most cases. Magnetic resonance imaging shows contrast enhancement of the acutely inflamed optic nerves. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic relapsing inflammatory optic neuropathy

Professional guidelines

PubMed

Saitakis G, Chwalisz BK
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179769. PMID: 36077167Free PMC Article
Papp V, Langkilde AR, Blinkenberg M, Schreiber K, Jensen PEH, Sellebjerg F
Mult Scler Relat Disord 2018 Nov;26:61-67. Epub 2018 Sep 11 doi: 10.1016/j.msard.2018.09.010. PMID: 30227311

Recent clinical studies

Etiology

Direk MÇ, Besen Ş, Öncel İ, Günbey C, Özdoğan O, Orgun LT, Sahin S, Cansu A, Yıldız N, Kanmaz S, Yılmaz S, Tekgül H, Türkdoğan D, Ünver O, Thomas GÖ, Başıbüyük S, Yılmaz D, Kurt AN, Gültutan P, Özsoy Ö, Yiş U, Kurul SH, Güngör S, Özgör B, Karadağ M, Dündar NO, Gençpınar P, Bildik O, Orak SA, Kabur ÇÇ, Kara B, Karaca Ö, Canpolat M, Gümüş H, Per H, Yılmaz Ü, Karaoğlu P, Ersoy Ö, Tosun A, Öztürk SB, Yüksel D, Atasoy E, Gücüyener K, Yıldırım M, Bektaş Ö, Çavuşoğlu D, Yarar Ç, Güngör O, Mert GG, Sarıgeçili E, Edizer S, Çetin İD, Aydın S, Diler B, Özdemir AA, Erol İ, Okuyaz Ç, Anlar B
Mult Scler Relat Disord 2024 Jan;81:105149. Epub 2023 Nov 26 doi: 10.1016/j.msard.2023.105149. PMID: 38096730
Bouffard MA, Mallery RM, Liao YJ, Torun N
J Neuroophthalmol 2021 Dec 1;41(4):476-479. doi: 10.1097/WNO.0000000000001310. PMID: 34310458Free PMC Article
Liu H, Zhou H, Wang J, Xu Q, Wei S
Br J Ophthalmol 2019 Oct;103(10):1423-1428. Epub 2018 Dec 4 doi: 10.1136/bjophthalmol-2018-313142. PMID: 30514710
Lee HJ, Kim B, Waters P, Woodhall M, Irani S, Ahn S, Kim SJ, Kim SM
J Neuroinflammation 2018 Oct 31;15(1):302. doi: 10.1186/s12974-018-1335-x. PMID: 30382857Free PMC Article
Petzold A, Plant GT
J Neurol 2014 Jan;261(1):17-26. Epub 2013 May 23 doi: 10.1007/s00415-013-6957-4. PMID: 23700317

Diagnosis

Kraker JA, Chen JJ
J Neurol 2023 Oct;270(10):5113-5126. Epub 2023 Aug 5 doi: 10.1007/s00415-023-11920-x. PMID: 37542657
Saitakis G, Chwalisz BK
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179769. PMID: 36077167Free PMC Article
Dhanapalaratnam R, Markoulli M, Krishnan AV
Clin Exp Optom 2022 Jan;105(1):3-12. Epub 2021 Aug 4 doi: 10.1080/08164622.2021.1947745. PMID: 34348598
Gise RA, Heidary G
Curr Neurol Neurosci Rep 2020 Mar 3;20(3):4. doi: 10.1007/s11910-020-1024-x. PMID: 32124097
Weber KP, Straumann D
J Neurol 2014 Jul;261(7):1251-6. Epub 2013 Sep 26 doi: 10.1007/s00415-013-7105-x. PMID: 24068370

Therapy

Liu H, Zhou H, Wang J, Xu Q, Wei S
Br J Ophthalmol 2019 Oct;103(10):1423-1428. Epub 2018 Dec 4 doi: 10.1136/bjophthalmol-2018-313142. PMID: 30514710
Lee HJ, Kim B, Waters P, Woodhall M, Irani S, Ahn S, Kim SJ, Kim SM
J Neuroinflammation 2018 Oct 31;15(1):302. doi: 10.1186/s12974-018-1335-x. PMID: 30382857Free PMC Article
Chen JJ, Flanagan EP, Jitprapaikulsan J, López-Chiriboga ASS, Fryer JP, Leavitt JA, Weinshenker BG, McKeon A, Tillema JM, Lennon VA, Tobin WO, Keegan BM, Lucchinetti CF, Kantarci OH, McClelland CM, Lee MS, Bennett JL, Pelak VS, Chen Y, VanStavern G, Adesina OO, Eggenberger ER, Acierno MD, Wingerchuk DM, Brazis PW, Sagen J, Pittock SJ
Am J Ophthalmol 2018 Nov;195:8-15. Epub 2018 Jul 26 doi: 10.1016/j.ajo.2018.07.020. PMID: 30055153Free PMC Article
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052
Kidd D, Burton B, Plant GT, Graham EM
Brain 2003 Feb;126(Pt 2):276-84. doi: 10.1093/brain/awg045. PMID: 12538397

Prognosis

Kraker JA, Chen JJ
J Neurol 2023 Oct;270(10):5113-5126. Epub 2023 Aug 5 doi: 10.1007/s00415-023-11920-x. PMID: 37542657
Saitakis G, Chwalisz BK
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179769. PMID: 36077167Free PMC Article
Dhanapalaratnam R, Markoulli M, Krishnan AV
Clin Exp Optom 2022 Jan;105(1):3-12. Epub 2021 Aug 4 doi: 10.1080/08164622.2021.1947745. PMID: 34348598
Gise RA, Heidary G
Curr Neurol Neurosci Rep 2020 Mar 3;20(3):4. doi: 10.1007/s11910-020-1024-x. PMID: 32124097
Gaier ED, Boudreault K, Rizzo JF 3rd, Falardeau J, Cestari DM
Curr Neurol Neurosci Rep 2015 Dec;15(12):76. doi: 10.1007/s11910-015-0598-1. PMID: 26467052

Clinical prediction guides

Direk MÇ, Besen Ş, Öncel İ, Günbey C, Özdoğan O, Orgun LT, Sahin S, Cansu A, Yıldız N, Kanmaz S, Yılmaz S, Tekgül H, Türkdoğan D, Ünver O, Thomas GÖ, Başıbüyük S, Yılmaz D, Kurt AN, Gültutan P, Özsoy Ö, Yiş U, Kurul SH, Güngör S, Özgör B, Karadağ M, Dündar NO, Gençpınar P, Bildik O, Orak SA, Kabur ÇÇ, Kara B, Karaca Ö, Canpolat M, Gümüş H, Per H, Yılmaz Ü, Karaoğlu P, Ersoy Ö, Tosun A, Öztürk SB, Yüksel D, Atasoy E, Gücüyener K, Yıldırım M, Bektaş Ö, Çavuşoğlu D, Yarar Ç, Güngör O, Mert GG, Sarıgeçili E, Edizer S, Çetin İD, Aydın S, Diler B, Özdemir AA, Erol İ, Okuyaz Ç, Anlar B
Mult Scler Relat Disord 2024 Jan;81:105149. Epub 2023 Nov 26 doi: 10.1016/j.msard.2023.105149. PMID: 38096730
Dhanapalaratnam R, Markoulli M, Krishnan AV
Clin Exp Optom 2022 Jan;105(1):3-12. Epub 2021 Aug 4 doi: 10.1080/08164622.2021.1947745. PMID: 34348598
Bouffard MA, Mallery RM, Liao YJ, Torun N
J Neuroophthalmol 2021 Dec 1;41(4):476-479. doi: 10.1097/WNO.0000000000001310. PMID: 34310458Free PMC Article
Alves JM, Seabra M, Braz L, Guimarães J
Mult Scler Relat Disord 2020 Sep;44:102337. Epub 2020 Jun 25 doi: 10.1016/j.msard.2020.102337. PMID: 32615530
Lee HJ, Kim B, Waters P, Woodhall M, Irani S, Ahn S, Kim SJ, Kim SM
J Neuroinflammation 2018 Oct 31;15(1):302. doi: 10.1186/s12974-018-1335-x. PMID: 30382857Free PMC Article

Recent systematic reviews

Petzold A, Plant GT
J Neurol 2014 Jan;261(1):17-26. Epub 2013 May 23 doi: 10.1007/s00415-013-6957-4. PMID: 23700317

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