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Adenomyosis

MedGen UID:
1805484
Concept ID:
C5574708
Disease or Syndrome
Synonym: Endometriosis of uterus
SNOMED CT: Endometriosis interna (198247003); Endometriosis of myometrium (237115002); Adenomyosis of uterus (784314006); Adenomyosis uteri (784314006); Uterine adenomyosis (784314006)
 
HPO: HP:0034326
Monarch Initiative: MONDO:0010888
OMIM®: 600458

Definition

Adenomyosis is characterized by the presence of endometrial glands and stroma within the myometrium. Abnormal uterine bleeding and dysmenorrhea are the most characteristic symptoms, occurring in approximately 65% of cases (Arnold et al., 1995). [from OMIM]

Professional guidelines

PubMed

Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M
J Obstet Gynaecol Can 2023 Jun;45(6):417-429.e1. doi: 10.1016/j.jogc.2023.04.008. PMID: 37244746
Lacheta J
Ceska Gynekol 2019 Spring;84(3):240-246. PMID: 31324117
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Pirtea P, de Ziegler D, Ayoubi JM
Fertil Steril 2023 May;119(5):741-745. Epub 2023 Mar 11 doi: 10.1016/j.fertnstert.2023.03.004. PMID: 36914148
Schrager S, Yogendran L, Marquez CM, Sadowski EA
Am Fam Physician 2022 Jan 1;105(1):33-38. PMID: 35029928
Upson K, Missmer SA
Semin Reprod Med 2020 May;38(2-03):89-107. Epub 2020 Oct 26 doi: 10.1055/s-0040-1718920. PMID: 33105509Free PMC Article
Vannuccini S, Petraglia F
F1000Res 2019;8 Epub 2019 Mar 13 doi: 10.12688/f1000research.17242.1. PMID: 30918629Free PMC Article

Diagnosis

Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Moawad G, Kheil MH, Ayoubi JM, Klebanoff JS, Rahman S, Sharara FI
J Assist Reprod Genet 2022 May;39(5):1027-1031. Epub 2022 Mar 28 doi: 10.1007/s10815-022-02476-2. PMID: 35347501Free PMC Article
Bourdon M, Santulli P, Marcellin L, Maignien C, Maitrot-Mantelet L, Bordonne C, Plu Bureau G, Chapron C
J Gynecol Obstet Hum Reprod 2021 Dec;50(10):102228. Epub 2021 Sep 11 doi: 10.1016/j.jogoh.2021.102228. PMID: 34520877
Upson K, Missmer SA
Semin Reprod Med 2020 May;38(2-03):89-107. Epub 2020 Oct 26 doi: 10.1055/s-0040-1718920. PMID: 33105509Free PMC Article
Lacheta J
Ceska Gynekol 2019 Spring;84(3):240-246. PMID: 31324117

Therapy

Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M
J Obstet Gynaecol Can 2023 Jun;45(6):417-429.e1. doi: 10.1016/j.jogc.2023.04.008. PMID: 37244746
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Moawad G, Kheil MH, Ayoubi JM, Klebanoff JS, Rahman S, Sharara FI
J Assist Reprod Genet 2022 May;39(5):1027-1031. Epub 2022 Mar 28 doi: 10.1007/s10815-022-02476-2. PMID: 35347501Free PMC Article
Schrager S, Yogendran L, Marquez CM, Sadowski EA
Am Fam Physician 2022 Jan 1;105(1):33-38. PMID: 35029928
Abbott JA
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:68-81. Epub 2016 Sep 30 doi: 10.1016/j.bpobgyn.2016.09.006. PMID: 27810281

Prognosis

Yoldemir T
Gynecol Endocrinol 2020 Jun;36(6):473-474. doi: 10.1080/09513590.2020.1773426. PMID: 32648499
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836
Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, Gordts S, Benacerraf B, D'Hooghe T, De Moor B, Brölmann H, Goldstein S, Epstein E, Bourne T, Timmerman D
Ultrasound Obstet Gynecol 2015 Sep;46(3):284-98. Epub 2015 Aug 10 doi: 10.1002/uog.14806. PMID: 25652685
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505

Clinical prediction guides

Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M
J Obstet Gynaecol Can 2023 Jun;45(6):417-429.e1. doi: 10.1016/j.jogc.2023.04.008. PMID: 37244746
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Moawad G, Kheil MH, Ayoubi JM, Klebanoff JS, Rahman S, Sharara FI
J Assist Reprod Genet 2022 May;39(5):1027-1031. Epub 2022 Mar 28 doi: 10.1007/s10815-022-02476-2. PMID: 35347501Free PMC Article
Bulun SE, Yildiz S, Adli M, Wei JJ
Hum Reprod Update 2021 Oct 18;27(6):1086-1097. doi: 10.1093/humupd/dmab017. PMID: 34131719Free PMC Article
Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, Noël JC, Pistofidis G, Van den Bosch T, Petraglia F
Hum Reprod Update 2020 Apr 15;26(3):392-411. doi: 10.1093/humupd/dmz049. PMID: 32097456

Recent systematic reviews

Francés-Herrero E, Lopez R, Hellström M, de Miguel-Gómez L, Herraiz S, Brännström M, Pellicer A, Cervelló I
Hum Reprod Update 2022 Nov 2;28(6):798-837. doi: 10.1093/humupd/dmac025. PMID: 35652272Free PMC Article
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Nirgianakis K, Kalaitzopoulos DR, Schwartz ASK, Spaanderman M, Kramer BW, Mueller MD, Mueller M
Reprod Biomed Online 2021 Jan;42(1):185-206. Epub 2020 Oct 4 doi: 10.1016/j.rbmo.2020.09.023. PMID: 33191131
Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y
Hum Reprod Update 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012. PMID: 31318420
Duckitt K, Collins S
BMJ Clin Evid 2012 Jan 18;2012 PMID: 22305976Free PMC Article

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