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Adenomyosis

MedGen UID:
1805484
•Concept ID:
C5574708
•
Disease or Syndrome
Synonym: Endometriosis of uterus
SNOMED CT: Endometriosis interna (198247003); Endometriosis of myometrium (237115002); Adenomyosis of uterus (784314006); Adenomyosis uteri (784314006); Uterine adenomyosis (784314006)
 
HPO: HP:0034326
Monarch Initiative: MONDO:0010888
OMIM®: 600458

Definition

Adenomyosis is characterized by the presence of endometrial glands and stroma within the myometrium. Abnormal uterine bleeding and dysmenorrhea are the most characteristic symptoms, occurring in approximately 65% of cases (Arnold et al., 1995). [from OMIM]

Professional guidelines

PubMed

Uterine adenomyosis: pathogenesis, diagnostics, symptomatology and treatment.
Lacheta J
Ceska Gynekol 2019 Spring;84(3):240-246. PMID: 31324117
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505

Recent clinical studies

Etiology

Association of endometriosis and adenomyosis with pregnancy and infertility.
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Epidemiology of Adenomyosis.
Upson K, Missmer SA
Semin Reprod Med 2020 May;38(2-03):89-107. Epub 2020 Oct 26 doi: 10.1055/s-0040-1718920. PMID: 33105509Free PMC Article
Recent advances in understanding and managing adenomyosis.
Vannuccini S, Petraglia F
F1000Res 2019;8 Epub 2019 Mar 13 doi: 10.12688/f1000research.17242.1. PMID: 30918629Free PMC Article
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
The Impact of Adenomyosis on Women's Fertility.
Harada T, Khine YM, Kaponis A, Nikellis T, Decavalas G, Taniguchi F
Obstet Gynecol Surv 2016 Sep;71(9):557-68. doi: 10.1097/OGX.0000000000000346. PMID: 27640610Free PMC Article

Diagnosis

Adenomyosis: An update regarding its diagnosis and clinical features.
Bourdon M, Santulli P, Marcellin L, Maignien C, Maitrot-Mantelet L, Bordonne C, Plu Bureau G, Chapron C
J Gynecol Obstet Hum Reprod 2021 Dec;50(10):102228. Epub 2021 Sep 11 doi: 10.1016/j.jogoh.2021.102228. PMID: 34520877
Adenomyosis and Infertility-Review of Medical and Surgical Approaches.
Szubert M, Koziróg E, Olszak O, Krygier-Kurz K, Kazmierczak J, Wilczynski J
Int J Environ Res Public Health 2021 Jan 30;18(3) doi: 10.3390/ijerph18031235. PMID: 33573117Free PMC Article
Uterine adenomyosis: pathogenesis, diagnostics, symptomatology and treatment.
Lacheta J
Ceska Gynekol 2019 Spring;84(3):240-246. PMID: 31324117
Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity.
Munro MG
Fertil Steril 2019 Apr;111(4):629-640. doi: 10.1016/j.fertnstert.2019.02.008. PMID: 30929720
Recent advances in understanding and managing adenomyosis.
Vannuccini S, Petraglia F
F1000Res 2019;8 Epub 2019 Mar 13 doi: 10.12688/f1000research.17242.1. PMID: 30918629Free PMC Article

Therapy

Association of endometriosis and adenomyosis with pregnancy and infertility.
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Adenomyosis and infertility.
Moawad G, Kheil MH, Ayoubi JM, Klebanoff JS, Rahman S, Sharara FI
J Assist Reprod Genet 2022 May;39(5):1027-1031. Epub 2022 Mar 28 doi: 10.1007/s10815-022-02476-2. PMID: 35347501Free PMC Article
Adenomyosis: Diagnosis and Management.
Schrager S, Yogendran L, Marquez CM, Sadowski EA
Am Fam Physician 2022 Jan 1;105(1):33-38. PMID: 35029928
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505

Prognosis

Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836
Pathogenesis of deep endometriosis.
Gordts S, Koninckx P, Brosens I
Fertil Steril 2017 Dec;108(6):872-885.e1. Epub 2017 Oct 31 doi: 10.1016/j.fertnstert.2017.08.036. PMID: 29100623
Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group.
Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, Gordts S, Benacerraf B, D'Hooghe T, De Moor B, Brölmann H, Goldstein S, Epstein E, Bourne T, Timmerman D
Ultrasound Obstet Gynecol 2015 Sep;46(3):284-98. Epub 2015 Aug 10 doi: 10.1002/uog.14806. PMID: 25652685
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505

Clinical prediction guides

Association of endometriosis and adenomyosis with pregnancy and infertility.
Vercellini P, Viganò P, Bandini V, Buggio L, Berlanda N, Somigliana E
Fertil Steril 2023 May;119(5):727-740. Epub 2023 Mar 21 doi: 10.1016/j.fertnstert.2023.03.018. PMID: 36948440
Adenomyosis and infertility.
Moawad G, Kheil MH, Ayoubi JM, Klebanoff JS, Rahman S, Sharara FI
J Assist Reprod Genet 2022 May;39(5):1027-1031. Epub 2022 Mar 28 doi: 10.1007/s10815-022-02476-2. PMID: 35347501Free PMC Article
Adenomyosis pathogenesis: insights from next-generation sequencing.
Bulun SE, Yildiz S, Adli M, Wei JJ
Hum Reprod Update 2021 Oct 18;27(6):1086-1097. doi: 10.1093/humupd/dmab017. PMID: 34131719Free PMC Article
Diagnosing adenomyosis: an integrated clinical and imaging approach.
Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, Noël JC, Pistofidis G, Van den Bosch T, Petraglia F
Hum Reprod Update 2020 Apr 15;26(3):392-411. doi: 10.1093/humupd/dmz049. PMID: 32097456
Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group.
Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, Gordts S, Benacerraf B, D'Hooghe T, De Moor B, Brölmann H, Goldstein S, Epstein E, Bourne T, Timmerman D
Ultrasound Obstet Gynecol 2015 Sep;46(3):284-98. Epub 2015 Aug 10 doi: 10.1002/uog.14806. PMID: 25652685

Recent systematic reviews

Bioengineering trends in female reproduction: a systematic review.
Francés-Herrero E, Lopez R, Hellström M, de Miguel-Gómez L, Herraiz S, Brännström M, Pellicer A, Cervelló I
Hum Reprod Update 2022 Nov 2;28(6):798-837. doi: 10.1093/humupd/dmac025. PMID: 35652272Free PMC Article
The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Fertility, pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis.
Nirgianakis K, Kalaitzopoulos DR, Schwartz ASK, Spaanderman M, Kramer BW, Mueller MD, Mueller M
Reprod Biomed Online 2021 Jan;42(1):185-206. Epub 2020 Oct 4 doi: 10.1016/j.rbmo.2020.09.023. PMID: 33191131
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis.
Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y
Hum Reprod Update 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012. PMID: 31318420
Adenomyosis: a systematic review of medical treatment.
Pontis A, D'Alterio MN, Pirarba S, de Angelis C, Tinelli R, Angioni S
Gynecol Endocrinol 2016 Sep;32(9):696-700. Epub 2016 Jul 5 doi: 10.1080/09513590.2016.1197200. PMID: 27379972

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