A recurrent form of sinusitis.

An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.

A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured.

Inflammation of the meninges.

Decreased levels of immunoglobulin A (IgA).

An abnormally decreased level of immunoglobulin M (IgM) in blood.

Complete lack of mature B cells, that is, of B cells that have left the bone marrow.

A transient reduction in the number of neutrophils in the peripheral blood. Transient neutropenia is most commonly associated with viral infections, but other causes include drugs and autoimmunity.

An abnormally decreased level of immunoglobulin G (IgG) in blood.

Type 1 diabetes mellitus (T1D), also designated insulin-dependent diabetes mellitus (IDDM), is a disorder of glucose homeostasis characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of T1D have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classic phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.