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Radiation-induced plexopathy

MedGen UID:
1809151
Concept ID:
C5681446
Disease or Syndrome
Synonyms: Disorder of nerve plexus due to and following radiation therapy; radiation-induced plexopathy
SNOMED CT: Radiation-induced plexopathy (1230019002); Disorder of nerve plexus due to and following radiation therapy (1230019002)
 
Monarch Initiative: MONDO:0033838
Orphanet: ORPHA521123

Definition

A rare radiation-induced disorder with characteristics of impairment of the peripheral nervous system at the level of the brachial or lumbosacral plexus following radiation therapy. Onset of symptoms can occur between several months up to decades after the last dose of radiation. Patients with radiation-induced brachial plexopathy typically present with mostly unilateral progressive paraesthesia, followed by weakness, atrophy and pain. Symptoms in radiation-induced lumbosacral plexopathy include more variable combinations of numbness, paraesthesia, pain and weakness and are more often bilateral. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation-induced plexopathy

Professional guidelines

PubMed

Pettigrew LC, Glass JP, Maor M, Zornoza J
Arch Neurol 1984 Dec;41(12):1282-5. doi: 10.1001/archneur.1984.04050230068022. PMID: 6093750

Recent clinical studies

Etiology

Delanian SE, Lenglet T, Maisonobe T, Resche-Rigon M, Pradat PF
Int J Radiat Oncol Biol Phys 2020 May 1;107(1):154-162. Epub 2020 Jan 24 doi: 10.1016/j.ijrobp.2020.01.002. PMID: 31987975
Teixeira MJ, Fonoff ET, Montenegro MC
Spine (Phila Pa 1976) 2007 May 1;32(10):E316-9. doi: 10.1097/01.brs.0000261541.97749.e7. PMID: 17471080
Hoeller U, Bonacker M, Bajrovic A, Alberti W, Adam G
Strahlenther Onkol 2004 Oct;180(10):650-4. doi: 10.1007/s00066-004-1240-3. PMID: 15480514
Lederman RJ, Wilbourn AJ
Neurology 1984 Oct;34(10):1331-5. doi: 10.1212/wnl.34.10.1331. PMID: 6090988

Diagnosis

Zandi MS
Handb Clin Neurol 2024;203:205-210. doi: 10.1016/B978-0-323-90820-7.00014-8. PMID: 39174249
Delanian SE, Lenglet T, Maisonobe T, Resche-Rigon M, Pradat PF
Int J Radiat Oncol Biol Phys 2020 May 1;107(1):154-162. Epub 2020 Jan 24 doi: 10.1016/j.ijrobp.2020.01.002. PMID: 31987975
Jaeckle KA
Semin Neurol 2004 Dec;24(4):385-93. doi: 10.1055/s-2004-861533. PMID: 15637650
Jaeckle KA
Neurol Clin 1991 Nov;9(4):857-66. PMID: 1722001
Albers JW, Allen AA 2nd, Bastron JA, Daube JR
Muscle Nerve 1981 Nov-Dec;4(6):494-504. doi: 10.1002/mus.880040606. PMID: 7311989

Therapy

Güler T, Yurdakul FG, Karasimav Ö, Kılıç Z, Yaşar E, Bodur H
Jt Dis Relat Surg 2024 Mar 21;35(2):455-461. doi: 10.52312/jdrs.2024.1551. PMID: 38727129Free PMC Article
Delanian SE, Lenglet T, Maisonobe T, Resche-Rigon M, Pradat PF
Int J Radiat Oncol Biol Phys 2020 May 1;107(1):154-162. Epub 2020 Jan 24 doi: 10.1016/j.ijrobp.2020.01.002. PMID: 31987975
Jaeckle KA
Semin Neurol 2004 Dec;24(4):385-93. doi: 10.1055/s-2004-861533. PMID: 15637650
Hoeller U, Bonacker M, Bajrovic A, Alberti W, Adam G
Strahlenther Onkol 2004 Oct;180(10):650-4. doi: 10.1007/s00066-004-1240-3. PMID: 15480514
Bowen BC, Verma A, Brandon AH, Fiedler JA
AJNR Am J Neuroradiol 1996 Nov-Dec;17(10):1932-6. PMID: 8933882Free PMC Article

Prognosis

Teixeira MJ, Fonoff ET, Montenegro MC
Spine (Phila Pa 1976) 2007 May 1;32(10):E316-9. doi: 10.1097/01.brs.0000261541.97749.e7. PMID: 17471080
Hoeller U, Bonacker M, Bajrovic A, Alberti W, Adam G
Strahlenther Onkol 2004 Oct;180(10):650-4. doi: 10.1007/s00066-004-1240-3. PMID: 15480514
Lederman RJ, Wilbourn AJ
Neurology 1984 Oct;34(10):1331-5. doi: 10.1212/wnl.34.10.1331. PMID: 6090988

Clinical prediction guides

Delanian SE, Lenglet T, Maisonobe T, Resche-Rigon M, Pradat PF
Int J Radiat Oncol Biol Phys 2020 May 1;107(1):154-162. Epub 2020 Jan 24 doi: 10.1016/j.ijrobp.2020.01.002. PMID: 31987975

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