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Abnormal placental adhesion into the uterine wall

MedGen UID:
1813075
•Concept ID:
C5676601
•
Pathologic Function
HPO: HP:0025652

Definition

Abnormal placental adhesion is characterized by an anomalous adherence of the placenta to the uterine wall. Based on the degree of adhesion, placental invasion can be classified into accreta, increta, or percreta. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal placental adhesion into the uterine wall

Professional guidelines

PubMed

Isthmocele: an overview of diagnosis and treatment.
Kremer TG, Ghiorzi IB, Dibi RP
Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. doi: 10.1590/1806-9282.65.5.714. PMID: 31166450

Recent clinical studies

Etiology

Identification of altered miRNAs and their targets in placenta accreta.
Murrieta-Coxca JM, Barth E, Fuentes-Zacarias P, Gutiérrez-Samudio RN, Groten T, Gellhaus A, Köninger A, Marz M, Markert UR, Morales-Prieto DM
Front Endocrinol (Lausanne) 2023;14:1021640. Epub 2023 Mar 3 doi: 10.3389/fendo.2023.1021640. PMID: 36936174Free PMC Article
Isthmocele: an overview of diagnosis and treatment.
Kremer TG, Ghiorzi IB, Dibi RP
Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. doi: 10.1590/1806-9282.65.5.714. PMID: 31166450
Revisiting decidual vasculopathy.
Hecht JL, Zsengeller ZK, Spiel M, Karumanchi SA, Rosen S
Placenta 2016 Jun;42:37-43. Epub 2016 Apr 8 doi: 10.1016/j.placenta.2016.04.006. PMID: 27238712
Why is placentation abnormal in preeclampsia?
Fisher SJ
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S115-22. doi: 10.1016/j.ajog.2015.08.042. PMID: 26428489Free PMC Article
Imaging after cesarean delivery: acute and chronic complications.
Rodgers SK, Kirby CL, Smith RJ, Horrow MM
Radiographics 2012 Oct;32(6):1693-712. doi: 10.1148/rg.326125516. PMID: 23065165

Diagnosis

Near-infrared and hysteroscopy-guided robotic excision of uterine isthmocele with laser fiber: a novel high-precision technique.
Walker Z, Gargiulo A
Fertil Steril 2023 Nov;120(5):1081-1083. Epub 2023 Aug 9 doi: 10.1016/j.fertnstert.2023.08.006. PMID: 37567494
Placenta accreta spectrum with severe morbidity: fibrosis associated with cervical-trigonal invasion.
Palacios-Jaraquemada JM, Nieto-Calvache ÁJ, Aryananda RA, Basanta N, Campos CI, Ariani G
J Matern Fetal Neonatal Med 2023 Dec;36(1):2183741. doi: 10.1080/14767058.2023.2183741. PMID: 37193605
Identification of altered miRNAs and their targets in placenta accreta.
Murrieta-Coxca JM, Barth E, Fuentes-Zacarias P, Gutiérrez-Samudio RN, Groten T, Gellhaus A, Köninger A, Marz M, Markert UR, Morales-Prieto DM
Front Endocrinol (Lausanne) 2023;14:1021640. Epub 2023 Mar 3 doi: 10.3389/fendo.2023.1021640. PMID: 36936174Free PMC Article
Isthmocele: an overview of diagnosis and treatment.
Kremer TG, Ghiorzi IB, Dibi RP
Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. doi: 10.1590/1806-9282.65.5.714. PMID: 31166450
Imaging after cesarean delivery: acute and chronic complications.
Rodgers SK, Kirby CL, Smith RJ, Horrow MM
Radiographics 2012 Oct;32(6):1693-712. doi: 10.1148/rg.326125516. PMID: 23065165

Therapy

Functional, patient-derived 3D tri-culture models of the uterine wall in a microfluidic array.
Busch C, Hill CJ, Paterson K, Mellin R, Zagnoni M, Hapangama DK, Sandison ME
Hum Reprod 2024 Nov 1;39(11):2537-2550. doi: 10.1093/humrep/deae214. PMID: 39277544Free PMC Article
Isthmocele: an overview of diagnosis and treatment.
Kremer TG, Ghiorzi IB, Dibi RP
Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. doi: 10.1590/1806-9282.65.5.714. PMID: 31166450
Appendiceal perforation by Copper-7 intrauterine contraceptive device.
Carson SA, Gatlin A, Mazur M
Am J Obstet Gynecol 1981 Nov 1;141(5):586-7. doi: 10.1016/s0002-9378(15)33284-1. PMID: 7294085

Prognosis

Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia.
Qu H, Khalil RA
Biochem Pharmacol 2022 Dec;206:115266. Epub 2022 Oct 1 doi: 10.1016/j.bcp.2022.115266. PMID: 36191626

Clinical prediction guides

Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia.
Qu H, Khalil RA
Biochem Pharmacol 2022 Dec;206:115266. Epub 2022 Oct 1 doi: 10.1016/j.bcp.2022.115266. PMID: 36191626
Searching for placenta percreta: a prospective cohort and systematic review of case reports.
Jauniaux E, Hecht JL, Elbarmelgy RA, Elbarmelgy RM, Thabet MM, Hussein AM
Am J Obstet Gynecol 2022 Jun;226(6):837.e1-837.e13. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.030. PMID: 34973177
Up-regulation of CD81 inhibits cytotrophoblast invasion and mediates maternal endothelial cell dysfunction in preeclampsia.
Shen L, Diao Z, Sun HX, Yan GJ, Wang Z, Li RT, Dai Y, Wang J, Li J, Ding H, Zhao G, Zheng M, Xue P, Liu M, Zhou Y, Hu Y
Proc Natl Acad Sci U S A 2017 Feb 21;114(8):1940-1945. Epub 2017 Feb 6 doi: 10.1073/pnas.1617601114. PMID: 28167787Free PMC Article
Why is placentation abnormal in preeclampsia?
Fisher SJ
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S115-22. doi: 10.1016/j.ajog.2015.08.042. PMID: 26428489Free PMC Article
Expression of cell adhesion molecules in the extravillous trophoblast is altered in IUGR.
Zygmunt M, Boving B, Wienhard J, Münstedt K, Braems G, Bohle RM, Lang U
Am J Reprod Immunol 1997 Oct;38(4):295-301. doi: 10.1111/j.1600-0897.1997.tb00518.x. PMID: 9352018

Recent systematic reviews

Searching for placenta percreta: a prospective cohort and systematic review of case reports.
Jauniaux E, Hecht JL, Elbarmelgy RA, Elbarmelgy RM, Thabet MM, Hussein AM
Am J Obstet Gynecol 2022 Jun;226(6):837.e1-837.e13. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.030. PMID: 34973177

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