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Anti-GluK2 antibody

MedGen UID:
1813975
•Concept ID:
C5551501
•
Finding
Synonym: Anti-glutamate kainate receptor subunit 2 antibody
 
HPO: HP:5000044

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamate kainate receptor subunit 2 (GluK2). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-GluK2 antibody

Professional guidelines

PubMed

Diagnostic criteria for autoimmune encephalitis: utility and pitfalls for antibody-negative disease.
Dalmau J, Graus F
Lancet Neurol 2023 Jun;22(6):529-540. doi: 10.1016/S1474-4422(23)00083-2. PMID: 37210100
Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents.
Cao Y, Jian F, Zhang Z, Yisimayi A, Hao X, Bao L, Yuan F, Yu Y, Du S, Wang J, Xiao T, Song W, Zhang Y, Liu P, An R, Wang P, Wang Y, Yang S, Niu X, Zhang Y, Gu Q, Shao F, Hu Y, Yin W, Zheng A, Wang Y, Qin C, Jin R, Xiao J, Xie XS
Cell Rep 2022 Dec 20;41(12):111845. Epub 2022 Dec 1 doi: 10.1016/j.celrep.2022.111845. PMID: 36493787Free PMC Article
Precision Modification of Native Antibodies.
Wu KL, Yu C, Lee C, Zuo C, Ball ZT, Xiao H
Bioconjug Chem 2021 Sep 15;32(9):1947-1959. Epub 2021 Aug 24 doi: 10.1021/acs.bioconjchem.1c00342. PMID: 34428033Free PMC Article
Monoclonal antibody pharmacokinetics and pharmacodynamics.
Wang W, Wang EQ, Balthasar JP
Clin Pharmacol Ther 2008 Nov;84(5):548-58. Epub 2008 Sep 10 doi: 10.1038/clpt.2008.170. PMID: 18784655
Induction therapy.
Bakr MA
Exp Clin Transplant 2005 Jun;3(1):320-8. PMID: 15989677
Antibody pharmacokinetics and pharmacodynamics.
Lobo ED, Hansen RJ, Balthasar JP
J Pharm Sci 2004 Nov;93(11):2645-68. doi: 10.1002/jps.20178. PMID: 15389672

Diagnosis

Management of autoimmune encephalitis.
Bien CG
Curr Opin Neurol 2021 Apr 1;34(2):166-171. doi: 10.1097/WCO.0000000000000909. PMID: 33464762
Bullous autoimmune dermatoses.
Hofmann SC, Juratli HA, Eming R
J Dtsch Dermatol Ges 2018 Nov;16(11):1339-1358. doi: 10.1111/ddg.13688. PMID: 30395395
Immunoglobulins--basic considerations.
Mix E, Goertsches R, Zett UK
J Neurol 2006 Sep;253 Suppl 5:V9-17. doi: 10.1007/s00415-006-5002-2. PMID: 16998762
Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources.
Lipman NS, Jackson LR, Trudel LJ, Weis-Garcia F
ILAR J 2005;46(3):258-68. doi: 10.1093/ilar.46.3.258. PMID: 15953833
Primary immunodeficiencies.
Bull World Health Organ 1971;45(1):125-42. PMID: 5004396Free PMC Article

Therapy

Litifilimab (BIIB059), a promising investigational drug for cutaneous lupus erythematosus.
Cho SK, Vazquez T, Werth VP
Expert Opin Investig Drugs 2023 May;32(5):345-353. Epub 2023 May 15 doi: 10.1080/13543784.2023.2212154. PMID: 37148249
Inebilizumab: A Review in Neuromyelitis Optica Spectrum Disorder.
Nie T, Blair HA
CNS Drugs 2022 Oct;36(10):1133-1141. Epub 2022 Sep 7 doi: 10.1007/s40263-022-00949-7. PMID: 36070074Free PMC Article
Bispecific antibodies: a mechanistic review of the pipeline.
Labrijn AF, Janmaat ML, Reichert JM, Parren PWHI
Nat Rev Drug Discov 2019 Aug;18(8):585-608. doi: 10.1038/s41573-019-0028-1. PMID: 31175342
Antibody-Drug Conjugate-Based Therapeutics: State of the Science.
Birrer MJ, Moore KN, Betella I, Bates RC
J Natl Cancer Inst 2019 Jun 1;111(6):538-549. doi: 10.1093/jnci/djz035. PMID: 30859213
The safety and side effects of monoclonal antibodies.
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665

Prognosis

Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis.
Gisondi P, Bellinato F, Targher G, Idolazzi L, Girolomoni G
Ann Rheum Dis 2022 Jan;81(1):68-73. Epub 2021 Jun 18 doi: 10.1136/annrheumdis-2021-219961. PMID: 34144965
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Cao Y, Su B, Guo X, Sun W, Deng Y, Bao L, Zhu Q, Zhang X, Zheng Y, Geng C, Chai X, He R, Li X, Lv Q, Zhu H, Deng W, Xu Y, Wang Y, Qiao L, Tan Y, Song L, Wang G, Du X, Gao N, Liu J, Xiao J, Su XD, Du Z, Feng Y, Qin C, Qin C, Jin R, Xie XS
Cell 2020 Jul 9;182(1):73-84.e16. Epub 2020 May 18 doi: 10.1016/j.cell.2020.05.025. PMID: 32425270Free PMC Article
Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study.
Shitara K, Iwata H, Takahashi S, Tamura K, Park H, Modi S, Tsurutani J, Kadowaki S, Yamaguchi K, Iwasa S, Saito K, Fujisaki Y, Sugihara M, Shahidi J, Doi T
Lancet Oncol 2019 Jun;20(6):827-836. Epub 2019 Apr 29 doi: 10.1016/S1470-2045(19)30088-9. PMID: 31047804
Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study.
Tamura K, Tsurutani J, Takahashi S, Iwata H, Krop IE, Redfern C, Sagara Y, Doi T, Park H, Murthy RK, Redman RA, Jikoh T, Lee C, Sugihara M, Shahidi J, Yver A, Modi S
Lancet Oncol 2019 Jun;20(6):816-826. Epub 2019 Apr 29 doi: 10.1016/S1470-2045(19)30097-X. PMID: 31047803
One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study.
Lewiecki EM, Dinavahi RV, Lazaretti-Castro M, Ebeling PR, Adachi JD, Miyauchi A, Gielen E, Milmont CE, Libanati C, Grauer A
J Bone Miner Res 2019 Mar;34(3):419-428. Epub 2018 Dec 3 doi: 10.1002/jbmr.3622. PMID: 30508316

Clinical prediction guides

Antibody-Dependent Enhancement with a Focus on SARS-CoV-2 and Anti-Glycan Antibodies.
Ziganshina MM, Shilova NV, Khalturina EO, Dolgushina NV, V Borisevich S, Yarotskaya EL, Bovin NV, Sukhikh GT
Viruses 2023 Jul 20;15(7) doi: 10.3390/v15071584. PMID: 37515270Free PMC Article
Antibody Dynamics and Durability in Coronavirus Disease-19.
Zuiani A, Wesemann DR
Clin Lab Med 2022 Mar;42(1):85-96. Epub 2021 Nov 3 doi: 10.1016/j.cll.2021.10.004. PMID: 35153050Free PMC Article
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Cao Y, Su B, Guo X, Sun W, Deng Y, Bao L, Zhu Q, Zhang X, Zheng Y, Geng C, Chai X, He R, Li X, Lv Q, Zhu H, Deng W, Xu Y, Wang Y, Qiao L, Tan Y, Song L, Wang G, Du X, Gao N, Liu J, Xiao J, Su XD, Du Z, Feng Y, Qin C, Qin C, Jin R, Xie XS
Cell 2020 Jul 9;182(1):73-84.e16. Epub 2020 May 18 doi: 10.1016/j.cell.2020.05.025. PMID: 32425270Free PMC Article
Human Monoclonal Antibodies: The Benefits of Humanization.
Waldmann H
Methods Mol Biol 2019;1904:1-10. doi: 10.1007/978-1-4939-8958-4_1. PMID: 30539464
Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients.
Barcellini W, Fattizzo B, Zaninoni A, Radice T, Nichele I, Di Bona E, Lunghi M, Tassinari C, Alfinito F, Ferrari A, Leporace AP, Niscola P, Carpenedo M, Boschetti C, Revelli N, Villa MA, Consonni D, Scaramucci L, De Fabritiis P, Tagariello G, Gaidano G, Rodeghiero F, Cortelezzi A, Zanella A
Blood 2014 Nov 6;124(19):2930-6. Epub 2014 Sep 16 doi: 10.1182/blood-2014-06-583021. PMID: 25232059

Recent systematic reviews

Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus in Infants and Children: A Systematic Review and Network Meta-analysis.
Sun M, Lai H, Na F, Li S, Qiu X, Tian J, Zhang Z, Ge L
JAMA Netw Open 2023 Feb 1;6(2):e230023. doi: 10.1001/jamanetworkopen.2023.0023. PMID: 36800182Free PMC Article
Tocilizumab and Active Antibody-Mediated Rejection in Kidney Transplantation: A Literature Review.
Cabezas L, Jouve T, Malvezzi P, Janbon B, Giovannini D, Rostaing L, Noble J
Front Immunol 2022;13:839380. Epub 2022 Apr 14 doi: 10.3389/fimmu.2022.839380. PMID: 35493469Free PMC Article
Post-COVID syndrome. A case series and comprehensive review.
Anaya JM, Rojas M, Salinas ML, Rodríguez Y, Roa G, Lozano M, Rodríguez-Jiménez M, Montoya N, Zapata E; Post-COVID study group, Monsalve DM, Acosta-Ampudia Y, Ramírez-Santana C
Autoimmun Rev 2021 Nov;20(11):102947. Epub 2021 Sep 10 doi: 10.1016/j.autrev.2021.102947. PMID: 34509649Free PMC Article
The Breast Milk Immunoglobulinome.
Rio-Aige K, Azagra-Boronat I, Castell M, Selma-Royo M, Collado MC, Rodríguez-Lagunas MJ, Pérez-Cano FJ
Nutrients 2021 May 26;13(6) doi: 10.3390/nu13061810. PMID: 34073540Free PMC Article
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D
BMJ 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. PMID: 29540345Free PMC Article

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