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Cartilaginous tracheobronchomalacia

MedGen UID:
1814106
•Concept ID:
C5558369
•
Disease or Syndrome
Synonym: Cartilaginous malacia
 
HPO: HP:0033990

Definition

Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCartilaginous tracheobronchomalacia

Professional guidelines

PubMed

Tracheobronchomalacia, Tracheobronchial Compression, and Tracheobronchial Malformations: Diagnostic and Treatment Strategies.
Kamran A, Baird CW, Jennings RW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:53-61. doi: 10.1053/j.pcsu.2020.02.006. PMID: 32354548
The dreaded desaturating baby: a difficult problem in clinical management.
Spitzer AR
Clin Perinatol 2007 Mar;34(1):55-71, vi. doi: 10.1016/j.clp.2006.12.013. PMID: 17394930
Treatment of adult tracheobronchomalacia and excessive dynamic airway collapse : an update.
Murgu SD, Colt HG
Treat Respir Med 2006;5(2):103-15. doi: 10.2165/00151829-200605020-00004. PMID: 16512691

Recent clinical studies

Etiology

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.
Kumar A, Praveen M, Tiwari N, Ramamoorthy HR, Joshi A, Parikh B
Ann Card Anaesth 2022 Oct-Dec;25(4):531-535. doi: 10.4103/aca.aca_112_21. PMID: 36254924Free PMC Article
Reoperation to correct unsuccessful vascular ring and vascular decompression surgery.
Labuz DF, Kamran A, Jennings RW, Baird CW
J Thorac Cardiovasc Surg 2022 Jul;164(1):199-207. Epub 2021 Nov 11 doi: 10.1016/j.jtcvs.2021.08.089. PMID: 34922756
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Tracheobronchomalacia: current concepts and controversies.
Ridge CA, O'donnell CR, Lee EY, Majid A, Boiselle PM
J Thorac Imaging 2011 Nov;26(4):278-89. doi: 10.1097/RTI.0b013e3182203342. PMID: 22009081
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Diagnosis

Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Current Concepts and Future Directions.
Aslam A, De Luis Cardenas J, Morrison RJ, Lagisetty KH, Litmanovich D, Sella EC, Lee E, Agarwal PP
Radiographics 2022 Jul-Aug;42(4):1012-1027. Epub 2022 May 6 doi: 10.1148/rg.210155. PMID: 35522576
Tracheobronchomalacia, Tracheobronchial Compression, and Tracheobronchial Malformations: Diagnostic and Treatment Strategies.
Kamran A, Baird CW, Jennings RW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:53-61. doi: 10.1053/j.pcsu.2020.02.006. PMID: 32354548
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Pediatric tracheomalacia.
Fraga JC, Jennings RW, Kim PC
Semin Pediatr Surg 2016 Jun;25(3):156-64. Epub 2016 Feb 22 doi: 10.1053/j.sempedsurg.2016.02.008. PMID: 27301602
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857

Therapy

Expiratory central airway collapse - an overlooked entity?: Two case reports.
Janowiak P, Rogoza K, Siemińska A, Jassem E
Medicine (Baltimore) 2020 Oct 16;99(42):e22449. doi: 10.1097/MD.0000000000022449. PMID: 33080680Free PMC Article
Dynamic Tracheobronchial Compression in Steep Trendelenburg Position With Pneumoperitoneum for Robotic-Assisted Cystectomy: A Case Report.
Babus LW, Gainsburg DM
A A Pract 2020 Jan 1;14(1):18-20. doi: 10.1213/XAA.0000000000001133. PMID: 31789827
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
A patient with relapsing polychondritis who had been diagnosed as intractable bronchial asthma.
Sato R, Ohshima N, Masuda K, Matsui H, Higaki N, Inoue E, Suzuki J, Nagai H, Akagawa S, Hebisawa A, Shoji S
Intern Med 2012;51(13):1773-8. Epub 2012 Jul 1 doi: 10.2169/internalmedicine.51.7621. PMID: 22790144
Tracheobronchomalacia and air trapping after mustard gas exposure.
Ghanei M, Akbari Moqadam F, Mohammad MM, Aslani J
Am J Respir Crit Care Med 2006 Feb 1;173(3):304-9. Epub 2005 Oct 27 doi: 10.1164/rccm.200502-247OC. PMID: 16254272

Prognosis

Expiratory central airway collapse - an overlooked entity?: Two case reports.
Janowiak P, Rogoza K, Siemińska A, Jassem E
Medicine (Baltimore) 2020 Oct 16;99(42):e22449. doi: 10.1097/MD.0000000000022449. PMID: 33080680Free PMC Article
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
What's in a name? Expiratory tracheal narrowing in adults explained.
Leong P, Bardin PG, Lau KK
Clin Radiol 2013 Dec;68(12):1268-75. Epub 2013 Aug 13 doi: 10.1016/j.crad.2013.06.017. PMID: 23953005
Central airway mechanics and flow limitation in acquired tracheobronchomalacia.
Loring SH, O'donnell CR, Feller-Kopman DJ, Ernst A
Chest 2007 Apr;131(4):1118-24. doi: 10.1378/chest.06-2556. PMID: 17426218
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Clinical prediction guides

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.
Kumar A, Praveen M, Tiwari N, Ramamoorthy HR, Joshi A, Parikh B
Ann Card Anaesth 2022 Oct-Dec;25(4):531-535. doi: 10.4103/aca.aca_112_21. PMID: 36254924Free PMC Article
BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.
Bottasso-Arias N, Leesman L, Burra K, Snowball J, Shah R, Mohanakrishnan M, Xu Y, Sinner D
Am J Physiol Lung Cell Mol Physiol 2022 Feb 1;322(2):L224-L242. Epub 2021 Dec 1 doi: 10.1152/ajplung.00255.2021. PMID: 34851738Free PMC Article
Lung disease associated with periventricular nodular heterotopia and an FLNA mutation.
Masurel-Paulet A, Haan E, Thompson EM, Goizet C, Thauvin-Robinet C, Tai A, Kennedy D, Smith G, Khong TY, Solé G, Guerineau E, Coupry I, Huet F, Robertson S, Faivre L
Eur J Med Genet 2011 Jan-Feb;54(1):25-8. Epub 2010 Oct 1 doi: 10.1016/j.ejmg.2010.09.010. PMID: 20888935
Longitudinal quantification of growth and changes in primary tracheobronchomalacia sites in children.
Masters IB, Zimmerman PV, Chang AB
Pediatr Pulmonol 2007 Oct;42(10):906-13. doi: 10.1002/ppul.20681. PMID: 17708575
Tracheobronchomalacia and air trapping after mustard gas exposure.
Ghanei M, Akbari Moqadam F, Mohammad MM, Aslani J
Am J Respir Crit Care Med 2006 Feb 1;173(3):304-9. Epub 2005 Oct 27 doi: 10.1164/rccm.200502-247OC. PMID: 16254272

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