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Cerebral cortical microinfarct

MedGen UID:
1814213
Concept ID:
C5676639
Disease or Syndrome
HPO: HP:0025714

Definition

An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Higashi E, Hatano T, Ando M, Chihara H, Ogura T, Suzuki K, Yamagami K, Kondo D, Kamata T, Sakai S, Sakamoto H, Nagata I
Neuroradiology 2021 Jul;63(7):1079-1085. Epub 2021 Jan 7 doi: 10.1007/s00234-020-02616-4. PMID: 33410949
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Ringman JM, Sachs MC, Zhou Y, Monsell SE, Saver JL, Vinters HV
JAMA Neurol 2014 Jul 1;71(7):878-83. doi: 10.1001/jamaneurol.2014.681. PMID: 24797962Free PMC Article

Recent clinical studies

Etiology

Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Rost NS, Etherton M
Continuum (Minneap Minn) 2020 Apr;26(2):332-352. doi: 10.1212/CON.0000000000000841. PMID: 32224755
Fazekas F, Gattringer T, Enzinger C
Curr Opin Neurol 2018 Aug;31(4):345-353. doi: 10.1097/WCO.0000000000000566. PMID: 29878907

Diagnosis

Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM
Brain 2017 Jul 1;140(7):1829-1850. doi: 10.1093/brain/awx047. PMID: 28334869Free PMC Article

Therapy

Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Wiegertjes K, Chan KS, Telgte AT, Gesierich B, Norris DG, Klijn CJ, Duering M, Tuladhar AM, Marques JP, Leeuw FE
J Cereb Blood Flow Metab 2021 Dec;41(12):3391-3399. Epub 2021 Aug 20 doi: 10.1177/0271678X211039609. PMID: 34415209Free PMC Article
Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H
EBioMedicine 2018 Jun;32:50-61. Epub 2018 Jun 5 doi: 10.1016/j.ebiom.2018.05.028. PMID: 29880270Free PMC Article
Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Yu JT
Curr Alzheimer Res 2017;14(7):802-808. doi: 10.2174/1567205013666161201200429. PMID: 27915996
Kleinig TJ
J Clin Neurosci 2013 Jul;20(7):919-27. Epub 2013 May 24 doi: 10.1016/j.jocn.2012.12.002. PMID: 23707603

Prognosis

Phan J, Ramos M, Soares T, Parmar MS
Oxid Med Cell Longev 2022;2022:7692215. Epub 2022 Oct 26 doi: 10.1155/2022/7692215. PMID: 36338344Free PMC Article
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Ferro DA, Kuijf HJ, Hilal S, van Veluw SJ, van Veldhuizen D, Venketasubramanian N, Tan BY, Biessels GJ, Chen C
Neurology 2022 Feb 8;98(6):e612-e622. Epub 2021 Dec 3 doi: 10.1212/WNL.0000000000013140. PMID: 34862322
Fazekas F, Gattringer T, Enzinger C
Curr Opin Neurol 2018 Aug;31(4):345-353. doi: 10.1097/WCO.0000000000000566. PMID: 29878907
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Clinical prediction guides

Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M
Circ Res 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14 doi: 10.1161/CIRCRESAHA.122.319951. PMID: 35420911
Ferro DA, Kuijf HJ, Hilal S, van Veluw SJ, van Veldhuizen D, Venketasubramanian N, Tan BY, Biessels GJ, Chen C
Neurology 2022 Feb 8;98(6):e612-e622. Epub 2021 Dec 3 doi: 10.1212/WNL.0000000000013140. PMID: 34862322
Sagnier S, Sibon I
J Neurosci Res 2022 May;100(5):1171-1181. Epub 2019 Sep 9 doi: 10.1002/jnr.24525. PMID: 31498491
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Wermer MJH, Greenberg SM
Curr Opin Neurol 2018 Feb;31(1):28-35. doi: 10.1097/WCO.0000000000000510. PMID: 29120920

Recent systematic reviews

Liu Y, Braidy N, Poljak A, Chan DKY, Sachdev P
Ageing Res Rev 2018 Nov;47:41-48. Epub 2018 Jun 26 doi: 10.1016/j.arr.2018.06.002. PMID: 29898422
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Yu JT
Curr Alzheimer Res 2017;14(7):802-808. doi: 10.2174/1567205013666161201200429. PMID: 27915996
Brundel M, de Bresser J, van Dillen JJ, Kappelle LJ, Biessels GJ
J Cereb Blood Flow Metab 2012 Mar;32(3):425-36. Epub 2012 Jan 11 doi: 10.1038/jcbfm.2011.200. PMID: 22234334Free PMC Article
Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):126-35. Epub 2010 Oct 9 doi: 10.1136/jnnp.2009.204685. PMID: 20935330

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