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Abnormal fetal skin morphology

MedGen UID:
1814219
•Concept ID:
C5676645
•
Congenital Abnormality
HPO: HP:0025723

Definition

Any structural anomaly of the skin of the fetus or newborn. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal fetal skin morphology

Professional guidelines

PubMed

Prenatal diagnosis of abdominal lymphatic malformations.
Liu YP, Huang YL, Tsai PS, Lin DC, Chen CP
Taiwan J Obstet Gynecol 2021 Jan;60(1):13-19. doi: 10.1016/j.tjog.2020.11.003. PMID: 33494985
Treatment of congenital malformations.
Brucker SY, Rall K, Campo R, Oppelt P, Isaacson K
Semin Reprod Med 2011 Mar;29(2):101-12. Epub 2011 Mar 24 doi: 10.1055/s-0031-1272472. PMID: 21437824
Prenatal genetic diagnosis. I.
Milunsky A, Littlefield JW, Kanfer JN, Kolodny EH, Shih VE, Atkins L
N Engl J Med 1970 Dec 17;283(25):1370-81. doi: 10.1056/NEJM197012172832505. PMID: 4921307

Recent clinical studies

Etiology

Hypohidrotic ectodermal dysplasia: clinical and molecular review.
Reyes-Reali J, Mendoza-Ramos MI, Garrido-Guerrero E, Méndez-Catalá CF, Méndez-Cruz AR, Pozo-Molina G
Int J Dermatol 2018 Aug;57(8):965-972. Epub 2018 May 31 doi: 10.1111/ijd.14048. PMID: 29855039
Management of pemphigus disease in pregnancy.
Tavakolpour S, Mirsafaei HS, Delshad S
Am J Reprod Immunol 2017 Jan;77(1) Epub 2016 Nov 8 doi: 10.1111/aji.12601. PMID: 27862562
Skin disease in pregnancy.
Soutou B, Aractingi S
Best Pract Res Clin Obstet Gynaecol 2015 Jul;29(5):732-40. Epub 2015 Mar 17 doi: 10.1016/j.bpobgyn.2015.03.005. PMID: 25862358
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013
Fetal parvovirus B19 infection.
von Kaisenberg CS, Jonat W
Ultrasound Obstet Gynecol 2001 Sep;18(3):280-8. doi: 10.1046/j.1469-0705.2001.00471.x. PMID: 11555463

Diagnosis

Prenatal Clinical Findings in RASA1-Related Capillary Malformation-Arteriovenous Malformation Syndrome.
Coccia E, Valeri L, Zuntini R, Caraffi SG, Peluso F, Pagliai L, Vezzani A, Pietrangiolillo Z, Leo F, Melli N, Fiorini V, Greco A, Lepri FR, Pisaneschi E, Marozza A, Carli D, Mussa A, Radio FC, Conti B, Iascone M, Gargano G, Novelli A, Tartaglia M, Zuffardi O, Bedeschi MF, Garavelli L
Genes (Basel) 2023 Feb 22;14(3) doi: 10.3390/genes14030549. PMID: 36980822Free PMC Article
Prenatal diagnosis of abdominal lymphatic malformations.
Liu YP, Huang YL, Tsai PS, Lin DC, Chen CP
Taiwan J Obstet Gynecol 2021 Jan;60(1):13-19. doi: 10.1016/j.tjog.2020.11.003. PMID: 33494985
Accessory Scrotum.
Fitouri F, Chebil N, Ben Ammar S, Sahli S, Hamzaoui M
Fetal Pediatr Pathol 2020 Feb;39(1):90-91. Epub 2019 Jun 19 doi: 10.1080/15513815.2019.1629133. PMID: 31215294
Disorders of the Umbilical Cord.
Muniraman H, Sardesai T, Sardesai S
Pediatr Rev 2018 Jul;39(7):332-341. doi: 10.1542/pir.2017-0202. PMID: 29967078
Commonest overgrowth syndromes.
Ekmektzoglou K, Demestiha T, Troupis G, Xanthos T
Fetal Pediatr Pathol 2012 Apr;31(2):94-111. doi: 10.3109/15513815.2011.650293. PMID: 22409408

Therapy

Management of pemphigus disease in pregnancy.
Tavakolpour S, Mirsafaei HS, Delshad S
Am J Reprod Immunol 2017 Jan;77(1) Epub 2016 Nov 8 doi: 10.1111/aji.12601. PMID: 27862562
Placenta-based therapies for the treatment of epidermolysis bullosa.
Nevala-Plagemann C, Lee C, Tolar J
Cytotherapy 2015 Jun;17(6):786-795. Epub 2015 Mar 18 doi: 10.1016/j.jcyt.2015.03.006. PMID: 25795271Free PMC Article
Intrapartum oximetry of the fetus.
East CE, Colditz PB
Anesth Analg 2007 Dec;105(6 Suppl):S59-S65. doi: 10.1213/01.ane.0000268493.90073.f3. PMID: 18048901
Fetoscopy.
Rauskolb R
J Perinat Med 1983;11(5):223-31. doi: 10.1515/jpme.1983.11.5.223. PMID: 6358450
Fetoscopy and fetal tissue sampling.
Rodeck CH, Nicolaides KH
Br Med Bull 1983 Oct;39(4):332-7. doi: 10.1093/oxfordjournals.bmb.a071844. PMID: 6357343

Prognosis

Application of an individualized nomogram in first-trimester screening for trisomy 21.
Sun Y, Zhang L, Dong D, Li X, Wang J, Yin C, Poon LC, Tian J, Wu Q
Ultrasound Obstet Gynecol 2021 Jul;58(1):56-66. doi: 10.1002/uog.22087. PMID: 32438493Free PMC Article
Disorders of the Umbilical Cord.
Muniraman H, Sardesai T, Sardesai S
Pediatr Rev 2018 Jul;39(7):332-341. doi: 10.1542/pir.2017-0202. PMID: 29967078
Prenatal findings in cardio-facio-cutaneous syndrome.
Templin L, Baumann C, Busa T, Heckenroth H, Pouvreau N, Toutain A, Cave H, Verloes A, Sigaudy S, Philip N
Am J Med Genet A 2016 Feb;170A(2):441-445. Epub 2015 Oct 22 doi: 10.1002/ajmg.a.37420. PMID: 26494162
Skin disease in pregnancy.
Soutou B, Aractingi S
Best Pract Res Clin Obstet Gynaecol 2015 Jul;29(5):732-40. Epub 2015 Mar 17 doi: 10.1016/j.bpobgyn.2015.03.005. PMID: 25862358
Fetal nuchal translucency thickness.
Witters I, Fryns JR
Genet Couns 2007;18(1):1-7. PMID: 17515296

Clinical prediction guides

Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice.
Chen G, Xiong S, Jing Q, van Gestel CAM, van Straalen NM, Roelofs D, Sun L, Qiu H
Sci Total Environ 2023 Jan 1;854:158666. Epub 2022 Sep 13 doi: 10.1016/j.scitotenv.2022.158666. PMID: 36108837
Generalized Pustular Psoriasis in Pregnancy: Current and Future Treatments.
Seishima M, Fujii K, Mizutani Y
Am J Clin Dermatol 2022 Sep;23(5):661-671. Epub 2022 Jun 15 doi: 10.1007/s40257-022-00698-9. PMID: 35704168
Accessory Scrotum.
Fitouri F, Chebil N, Ben Ammar S, Sahli S, Hamzaoui M
Fetal Pediatr Pathol 2020 Feb;39(1):90-91. Epub 2019 Jun 19 doi: 10.1080/15513815.2019.1629133. PMID: 31215294
Fetal nuchal translucency thickness.
Witters I, Fryns JR
Genet Couns 2007;18(1):1-7. PMID: 17515296
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013

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