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Probst bundles

MedGen UID:
1814227
Concept ID:
C5676654
Finding
HPO: HP:0034054

Definition

Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles. [from HPO]

Conditions with this feature

Chromosome 6q24-q25 deletion syndrome
MedGen UID:
461565
Concept ID:
C3150215
Disease or Syndrome
6q25 microdeletion syndrome is a recently described syndrome characterized by developmental delay, facial dysmorphism and hearing loss.
Macrocephaly, acquired, with impaired intellectual development
MedGen UID:
1648471
Concept ID:
C4748993
Disease or Syndrome

Professional guidelines

PubMed

Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP; Intermountain Healthcare Intensive Medicine Clinical Program
Am J Respir Crit Care Med 2013 Jul 1;188(1):77-82. doi: 10.1164/rccm.201212-2199OC. PMID: 23631750Free PMC Article
Smits JP, Eckardt L, Probst V, Bezzina CR, Schott JJ, Remme CA, Haverkamp W, Breithardt G, Escande D, Schulze-Bahr E, LeMarec H, Wilde AA
J Am Coll Cardiol 2002 Jul 17;40(2):350-6. doi: 10.1016/s0735-1097(02)01962-9. PMID: 12106943

Recent clinical studies

Etiology

Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Severino M, Tortora D, Toselli B, Uccella S, Traverso M, Morana G, Capra V, Veneselli E, Fato MM, Rossi A
AJNR Am J Neuroradiol 2017 Mar;38(3):639-647. Epub 2017 Jan 19 doi: 10.3174/ajnr.A5043. PMID: 28104634Free PMC Article
Bulakbasi N, Cancuri O, Kocaoğlu M
Br J Radiol 2016 Jul;89(1063):20160115. Epub 2016 Apr 19 doi: 10.1259/bjr.20160115. PMID: 27089898Free PMC Article
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Neal JB, Filippi CG, Mayeux R
BMC Neurol 2015 Jul 25;15:116. doi: 10.1186/s12883-015-0382-5. PMID: 26209096Free PMC Article

Diagnosis

Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Jackson EM, Cohen AR
J Neurosurg Pediatr 2018 May;21(5):496-497. Epub 2018 Mar 2 doi: 10.3171/2018.1.PEDS17667. PMID: 29498606
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Neal JB, Filippi CG, Mayeux R
BMC Neurol 2015 Jul 25;15:116. doi: 10.1186/s12883-015-0382-5. PMID: 26209096Free PMC Article
Tonni G, Azzoni D, Ventura A, Ambrosetti F, De Felice C
Fetal Pediatr Pathol 2008;27(6):264-73. doi: 10.1080/15513810802448076. PMID: 19065324

Therapy

Lazarev VV, de Carvalho Monteiro M, Vianna-Barbosa R, deAzevedo LC, Lent R, Tovar-Moll F
PLoS One 2016;11(4):e0152668. Epub 2016 Apr 7 doi: 10.1371/journal.pone.0152668. PMID: 27055255Free PMC Article

Prognosis

Millischer AE, Grevent D, Sonigo P, Bahi-Buisson N, Desguerre I, Mahallati H, Bault JP, Quibel T, Couderc S, Moutard ML, Julien E, Dangouloff V, Bessieres B, Malan V, Attie T, Salomon LJ, Boddaert N
AJNR Am J Neuroradiol 2022 Jan;43(1):132-138. Epub 2021 Dec 23 doi: 10.3174/ajnr.A7383. PMID: 34949593Free PMC Article
Ohashi E, Hayakawa I, Abe Y, Tsutsumi Y, Kubota M
Intern Med 2021 Aug 15;60(16):2667-2670. Epub 2021 Mar 1 doi: 10.2169/internalmedicine.6840-20. PMID: 33642486Free PMC Article
Bulakbasi N, Cancuri O, Kocaoğlu M
Br J Radiol 2016 Jul;89(1063):20160115. Epub 2016 Apr 19 doi: 10.1259/bjr.20160115. PMID: 27089898Free PMC Article
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Owen JP, Li YO, Ziv E, Strominger Z, Gold J, Bukhpun P, Wakahiro M, Friedman EJ, Sherr EH, Mukherjee P
Neuroimage 2013 Apr 15;70:340-55. Epub 2012 Dec 23 doi: 10.1016/j.neuroimage.2012.12.031. PMID: 23268782Free PMC Article

Clinical prediction guides

Lazarev VV, de Carvalho Monteiro M, Vianna-Barbosa R, deAzevedo LC, Lent R, Tovar-Moll F
PLoS One 2016;11(4):e0152668. Epub 2016 Apr 7 doi: 10.1371/journal.pone.0152668. PMID: 27055255Free PMC Article
Al-Hashim AH, Blaser S, Raybaud C, MacGregor D
Dev Med Child Neurol 2016 May;58(5):475-84. Epub 2015 Dec 9 doi: 10.1111/dmcn.12978. PMID: 26661037
Bénézit A, Hertz-Pannier L, Dehaene-Lambertz G, Monzalvo K, Germanaud D, Duclap D, Guevara P, Mangin JF, Poupon C, Moutard ML, Dubois J
Cortex 2015 Feb;63:155-71. Epub 2014 Sep 11 doi: 10.1016/j.cortex.2014.08.022. PMID: 25282054
Owen JP, Li YO, Ziv E, Strominger Z, Gold J, Bukhpun P, Wakahiro M, Friedman EJ, Sherr EH, Mukherjee P
Neuroimage 2013 Apr 15;70:340-55. Epub 2012 Dec 23 doi: 10.1016/j.neuroimage.2012.12.031. PMID: 23268782Free PMC Article

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