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Anti-phosphatidic acid antibody positivity

MedGen UID:
1814262
•Concept ID:
C5676692
•
Finding
HPO: HP:0034096

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidic acid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-phosphatidic acid antibody positivity

Professional guidelines

PubMed

Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Li S, Bai Y, Meng J, Wang Q, Tian X, Li M, Zeng X, Zhao J, Hu C
Front Immunol 2023;14:1107510. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1107510. PMID: 37122726Free PMC Article
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842
Examining the prevalence of non-criteria anti-phospholipid antibodies in patients with anti-phospholipid syndrome: a systematic review.
Rodríguez-García V, Ioannou Y, Fernández-Nebro A, Isenberg DA, Giles IP
Rheumatology (Oxford) 2015 Nov;54(11):2042-50. Epub 2015 Jul 7 doi: 10.1093/rheumatology/kev226. PMID: 26152548

Recent clinical studies

Etiology

Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Li S, Bai Y, Meng J, Wang Q, Tian X, Li M, Zeng X, Zhao J, Hu C
Front Immunol 2023;14:1107510. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1107510. PMID: 37122726Free PMC Article
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842
The hidden world of anti-phospholipid antibodies and female infertility: A literature appraisal.
Chighizola CB, de Jesus GR, Branch DW
Autoimmun Rev 2016 Jun;15(6):493-500. Epub 2016 Jan 29 doi: 10.1016/j.autrev.2016.01.018. PMID: 26827907
Examining the prevalence of non-criteria anti-phospholipid antibodies in patients with anti-phospholipid syndrome: a systematic review.
Rodríguez-García V, Ioannou Y, Fernández-Nebro A, Isenberg DA, Giles IP
Rheumatology (Oxford) 2015 Nov;54(11):2042-50. Epub 2015 Jul 7 doi: 10.1093/rheumatology/kev226. PMID: 26152548
High prevalence of anti-phospholipid antibodies and anti-thyroglobulin antibody in patients with hepatitis C virus infection treated with interferon-alpha.
Matsuda J, Saitoh N, Gotoh M, Gohchi K, Tsukamoto M, Syoji S, Miyake K, Yamanaka M
Am J Gastroenterol 1995 Jul;90(7):1138-41. PMID: 7611213

Diagnosis

Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Li S, Bai Y, Meng J, Wang Q, Tian X, Li M, Zeng X, Zhao J, Hu C
Front Immunol 2023;14:1107510. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1107510. PMID: 37122726Free PMC Article
Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome.
Anunciación-Llunell A, Muñoz C, Roggenbuck D, Frasca S, Pardos-Gea J, Esteve-Valverde E, Alijotas-Reig J, Miró-Mur F
Int J Mol Sci 2022 Oct 24;23(21) doi: 10.3390/ijms232112819. PMID: 36361608Free PMC Article
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842
The hidden world of anti-phospholipid antibodies and female infertility: A literature appraisal.
Chighizola CB, de Jesus GR, Branch DW
Autoimmun Rev 2016 Jun;15(6):493-500. Epub 2016 Jan 29 doi: 10.1016/j.autrev.2016.01.018. PMID: 26827907

Therapy

High prevalence of anti-phospholipid antibodies and anti-thyroglobulin antibody in patients with hepatitis C virus infection treated with interferon-alpha.
Matsuda J, Saitoh N, Gotoh M, Gohchi K, Tsukamoto M, Syoji S, Miyake K, Yamanaka M
Am J Gastroenterol 1995 Jul;90(7):1138-41. PMID: 7611213

Prognosis

Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842

Clinical prediction guides

Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Li S, Bai Y, Meng J, Wang Q, Tian X, Li M, Zeng X, Zhao J, Hu C
Front Immunol 2023;14:1107510. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1107510. PMID: 37122726Free PMC Article
Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome.
Anunciación-Llunell A, Muñoz C, Roggenbuck D, Frasca S, Pardos-Gea J, Esteve-Valverde E, Alijotas-Reig J, Miró-Mur F
Int J Mol Sci 2022 Oct 24;23(21) doi: 10.3390/ijms232112819. PMID: 36361608Free PMC Article
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842
High prevalence of anti-phospholipid antibodies and anti-thyroglobulin antibody in patients with hepatitis C virus infection treated with interferon-alpha.
Matsuda J, Saitoh N, Gotoh M, Gohchi K, Tsukamoto M, Syoji S, Miyake K, Yamanaka M
Am J Gastroenterol 1995 Jul;90(7):1138-41. PMID: 7611213

Recent systematic reviews

Examining the prevalence of non-criteria anti-phospholipid antibodies in patients with anti-phospholipid syndrome: a systematic review.
Rodríguez-García V, Ioannou Y, Fernández-Nebro A, Isenberg DA, Giles IP
Rheumatology (Oxford) 2015 Nov;54(11):2042-50. Epub 2015 Jul 7 doi: 10.1093/rheumatology/kev226. PMID: 26152548

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