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Anti-neutrophil elastase antibody positivity

MedGen UID:
1814270
•Concept ID:
C5676700
•
Finding
HPO: HP:0034104

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neutrophil elastase. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-neutrophil elastase antibody positivity

Recent clinical studies

Etiology

Occurrence and Antigenic Specificity of Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA) in Systemic Autoimmune Diseases.
Argyropoulou OD, Goules AV, Boutzios G, Tsirogianni A, Sfontouris C, Manoussakis MN, Vlachoyiannopoulos PG, Tzioufas AG, Kapsogeorgou EK
Cells 2021 Aug 19;10(8) doi: 10.3390/cells10082128. PMID: 34440897Free PMC Article
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Talor MV, Stone JH, Stebbing J, Barin J, Rose NR, Burek CL
Clin Exp Immunol 2007 Oct;150(1):42-8. Epub 2007 Jul 5 doi: 10.1111/j.1365-2249.2007.03453.x. PMID: 17614969Free PMC Article
Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.
Audrain MA, Sesboüé R, Baranger TA, Elliott J, Testa A, Martin JP, Lockwood CM, Esnault VL
Nephrol Dial Transplant 2001 Jan;16(1):39-44. doi: 10.1093/ndt/16.1.39. PMID: 11208991
Periodontitis and anti-neutrophil cytoplasmic antibodies in systemic lupus erythematosus and rheumatoid arthritis: a comparative study.
Novo E, Garcia-MacGregor E, Viera N, Chaparro N, Crozzoli Y
J Periodontol 1999 Feb;70(2):185-8. doi: 10.1902/jop.1999.70.2.185. PMID: 10102556
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease).
Halacheva KS, Manolova IM, Petkov DP, Andreev AP
Scand J Immunol 1998 Nov;48(5):544-50. PMID: 9822265

Diagnosis

Granulomatosis with polyangiitis or its mimic? A case report.
Major T, Nagy G, Szabó J, Mózes H, Szűcs G, Szekanecz Z, Szamosi S
J Int Med Res 2024 Apr;52(4):3000605241237876. doi: 10.1177/03000605241237876. PMID: 38606757Free PMC Article
Occurrence and Antigenic Specificity of Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA) in Systemic Autoimmune Diseases.
Argyropoulou OD, Goules AV, Boutzios G, Tsirogianni A, Sfontouris C, Manoussakis MN, Vlachoyiannopoulos PG, Tzioufas AG, Kapsogeorgou EK
Cells 2021 Aug 19;10(8) doi: 10.3390/cells10082128. PMID: 34440897Free PMC Article
Cocaine induced midline destructive lesions.
Trimarchi M, Bertazzoni G, Bussi M
Rhinology 2014 Jun;52(2):104-111. doi: 10.4193/Rhino13.112. PMID: 24932619
Study about correlation of anti-neutrophil cytoplasmic antibodies and anticardiolipin antibodies with thromboangiitis obliterans.
Guo Y, Dai Y, Lai J, Fan Y
Vascular 2013 Dec;21(6):363–8. doi: 10.1177/1708538113478742. PMID: 23493272
Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephritis.
Bygren P, Rasmussen N, Isaksson B, Wieslander J
Eur J Clin Invest 1992 Dec;22(12):783-92. doi: 10.1111/j.1365-2362.1992.tb01447.x. PMID: 1478249

Therapy

Vasculopathy related to cocaine adulterated with levamisole: A review of the literature.
Pearson T, Bremmer M, Cohen J, Driscoll M
Dermatol Online J 2012 Jul 15;18(7):1. PMID: 22863623
Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation.
Marina VP, Malhotra D, Kaw D
Int Urol Nephrol 2012 Dec;44(6):1907-9. Epub 2011 May 17 doi: 10.1007/s11255-011-9989-7. PMID: 21590349
A case of cocaine-induced panhypopituitarism with human neutrophil elastase-specific anti-neutrophil cytoplasmic antibodies.
de Lange TE, Simsek S, Kramer MH, Nanayakkara PW
Eur J Endocrinol 2009 Mar;160(3):499-502. Epub 2008 Dec 29 doi: 10.1530/EJE-08-0941. PMID: 19114541
Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.
Herlin T, Birkebaek NH, Wolthers OD, Heegaard NH, Wiik A
Scand J Rheumatol 2002;31(1):46-9. doi: 10.1080/030097402317255381. PMID: 11924649
Case of propylthiouracil-induced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature.
Kitahara T, Hiromura K, Maezawa A, Ono K, Narabara N, Yano S, Naruse T, Takenouchi K, Yasumoto Y
Clin Nephrol 1997 May;47(5):336-40. PMID: 9181282

Prognosis

Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK).
Lindgren S, Nilsson S, Nässberger L, Verbaan H, Wieslander J
J Gastroenterol Hepatol 2000 Apr;15(4):437-42. doi: 10.1046/j.1440-1746.2000.02078.x. PMID: 10824890
Alpha1-antitrypsin phenotypes and anti-neutrophil cytoplasmic auto-antibodies in inflammatory bowel disease.
Taddei C, Audrain MA, Reumaux D, Sesboüe R, Testa A, Galmiche JP, Duthilleul P, Colombel JF, Esnault VL
Eur J Gastroenterol Hepatol 1999 Nov;11(11):1293-8. doi: 10.1097/00042737-199911000-00019. PMID: 10563543
Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features.
Nishiya K, Chikazawa H, Nishimura S, Hisakawa N, Hashimoto K
Clin Rheumatol 1997 Jan;16(1):70-5. doi: 10.1007/BF02238766. PMID: 9132329
Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals.
Savige JA, Chang L, Horn S, Crowe SM
Autoimmunity 1994;18(3):205-11. doi: 10.3109/08916939409007997. PMID: 7858105

Clinical prediction guides

Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK).
Lindgren S, Nilsson S, Nässberger L, Verbaan H, Wieslander J
J Gastroenterol Hepatol 2000 Apr;15(4):437-42. doi: 10.1046/j.1440-1746.2000.02078.x. PMID: 10824890
Periodontitis and anti-neutrophil cytoplasmic antibodies in systemic lupus erythematosus and rheumatoid arthritis: a comparative study.
Novo E, Garcia-MacGregor E, Viera N, Chaparro N, Crozzoli Y
J Periodontol 1999 Feb;70(2):185-8. doi: 10.1902/jop.1999.70.2.185. PMID: 10102556
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease).
Halacheva KS, Manolova IM, Petkov DP, Andreev AP
Scand J Immunol 1998 Nov;48(5):544-50. PMID: 9822265
Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features.
Nishiya K, Chikazawa H, Nishimura S, Hisakawa N, Hashimoto K
Clin Rheumatol 1997 Jan;16(1):70-5. doi: 10.1007/BF02238766. PMID: 9132329
In situ localization by double-labeling immunoelectron microscopy of anti-neutrophil cytoplasmic autoantibodies in neutrophils and monocytes.
Calafat J, Goldschmeding R, Ringeling PL, Janssen H, van der Schoot CE
Blood 1990 Jan 1;75(1):242-50. PMID: 2153032

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