Anti-sp100 antibody positivity

MedGen UID:: 1814320
•Concept ID:: C5676751
•: Laboratory or Test Result

HPO:	HP:0034155

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against sp100. Autoantibodies causing the MND pattern are directed against sp100, sp140, promyelocytic leukemia nuclear body proteins (PML) or ubiquitin-like modifier (SUMO) proteins, while in the punctate nuclear envelope pattern, the target antigens are gp210, nucleoporin-62 or laminin B receptor proteins. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAnti-sp100 antibody positivity

Abnormal Immunology Test Result
- Antinuclear antibody positivity
  - Anti-multiple nuclear dots antibody positivity
    - Anti-sp100 antibody positivity

Professional guidelines

PubMed

Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis.

Mytilinaiou MG, Meyer W, Scheper T, Rigopoulou EI, Probst C, Koutsoumpas AL, Abeles D, Burroughs AK, Komorowski L, Vergani D, Bogdanos DP
Clin Chim Acta 2012 Aug 16;413(15-16):1211-6. Epub 2012 Apr 3 doi: 10.1016/j.cca.2012.03.020. PMID: 22503841

Value of autoantibody analysis in the differential diagnosis of chronic cholestatic liver disease.

Milkiewicz P, Buwaneswaran H, Coltescu C, Shums Z, Norman GL, Heathcote EJ
Clin Gastroenterol Hepatol 2009 Dec;7(12):1355-60. Epub 2009 Jul 22 doi: 10.1016/j.cgh.2009.07.012. PMID: 19631286

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Anti-sp100 antibody positivity

Definition

Term Hierarchy

Professional guidelines

PubMed

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