U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anti-titin antibody positivity

MedGen UID:
1814430
•Concept ID:
C5676867
•
Finding
Synonym: Anti-titin antibody
 
HPO: HP:5000038

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against titin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-titin antibody positivity

Professional guidelines

PubMed

Late-onset generalized myasthenia gravis: clinical features, treatment, and outcome.
Yildiz Celik S, Durmus H, Yilmaz V, Saruhan Direskeneli G, Gulsen Parman Y, Serdaroglu Oflazer P, Deymeer F
Acta Neurol Belg 2020 Feb;120(1):133-140. Epub 2019 Dec 6 doi: 10.1007/s13760-019-01252-x. PMID: 31811563

Recent clinical studies

Etiology

Seroprevalence of neuronal antibodies in diseases mimicking autoimmune encephalitis.
Vaisvilas M, Petrosian D, Bagdonaite L, Taluntiene V, Kralikiene V, Daugelaviciene N, Neniskyte U, Kaubrys G, Giedraitiene N
Sci Rep 2024 Mar 4;14(1):5352. doi: 10.1038/s41598-024-55995-6. PMID: 38438516Free PMC Article
Anti-titin antibodies are associated with myocarditis in patients with myasthenia gravis.
Kim S, Kim KH, Chung HY, Park HJ, Choi YC, Shin HY, Kim SW
J Neurol 2023 Mar;270(3):1457-1465. Epub 2022 Nov 16 doi: 10.1007/s00415-022-11485-1. PMID: 36383260
Muscular pathological features in patients with myasthenia gravis.
Qiao L, Zhang Y, Ban R, Lin Y, Pu C, Shi Q
Clin Neuropathol 2021 Nov-Dec;40(6):319-327. doi: 10.5414/NP301382. PMID: 34236310
Paraneoplastic neurological syndromes with onconeural antibodies: A single center retrospective study.
Oliveira V, Videira G, Samões R, Carneiro P, Neves E, Santos E
J Neurol Sci 2020 Nov 15;418:117103. Epub 2020 Aug 21 doi: 10.1016/j.jns.2020.117103. PMID: 32877801
Late-onset generalized myasthenia gravis: clinical features, treatment, and outcome.
Yildiz Celik S, Durmus H, Yilmaz V, Saruhan Direskeneli G, Gulsen Parman Y, Serdaroglu Oflazer P, Deymeer F
Acta Neurol Belg 2020 Feb;120(1):133-140. Epub 2019 Dec 6 doi: 10.1007/s13760-019-01252-x. PMID: 31811563

Diagnosis

Seroprevalence of neuronal antibodies in diseases mimicking autoimmune encephalitis.
Vaisvilas M, Petrosian D, Bagdonaite L, Taluntiene V, Kralikiene V, Daugelaviciene N, Neniskyte U, Kaubrys G, Giedraitiene N
Sci Rep 2024 Mar 4;14(1):5352. doi: 10.1038/s41598-024-55995-6. PMID: 38438516Free PMC Article
Anti-titin antibodies are associated with myocarditis in patients with myasthenia gravis.
Kim S, Kim KH, Chung HY, Park HJ, Choi YC, Shin HY, Kim SW
J Neurol 2023 Mar;270(3):1457-1465. Epub 2022 Nov 16 doi: 10.1007/s00415-022-11485-1. PMID: 36383260
Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody.
Ono R, Iwai Y, Yamazaki T, Takahashi H, Hori Y, Fukushima K, Saotome T
Intern Med 2022 Oct 1;61(19):2973-2979. Epub 2022 Mar 19 doi: 10.2169/internalmedicine.8772-21. PMID: 35314545Free PMC Article
Muscular pathological features in patients with myasthenia gravis.
Qiao L, Zhang Y, Ban R, Lin Y, Pu C, Shi Q
Clin Neuropathol 2021 Nov-Dec;40(6):319-327. doi: 10.5414/NP301382. PMID: 34236310
Inflammatory myopathy with myasthenia gravis: Thymoma association and polymyositis pathology.
Uchio N, Taira K, Ikenaga C, Kadoya M, Unuma A, Yoshida K, Nakatani-Enomoto S, Hatanaka Y, Sakurai Y, Shiio Y, Kaida K, Kubota A, Toda T, Shimizu J
Neurol Neuroimmunol Neuroinflamm 2019 Mar;6(2):e535. Epub 2018 Dec 24 doi: 10.1212/NXI.0000000000000535. PMID: 30697585Free PMC Article

Therapy

Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody.
Ono R, Iwai Y, Yamazaki T, Takahashi H, Hori Y, Fukushima K, Saotome T
Intern Med 2022 Oct 1;61(19):2973-2979. Epub 2022 Mar 19 doi: 10.2169/internalmedicine.8772-21. PMID: 35314545Free PMC Article
Pembrolizumab-induced Ocular Myasthenia Gravis with Anti-titin Antibody and Necrotizing Myopathy.
Onda A, Miyagawa S, Takahashi N, Gochi M, Takagi M, Nishino I, Suzuki S, Oishi C, Yaguchi H
Intern Med 2019 Jun 1;58(11):1635-1638. Epub 2019 Feb 1 doi: 10.2169/internalmedicine.1956-18. PMID: 30713313Free PMC Article
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population.
Maniaol AH, Elsais A, Lorentzen ÅR, Owe JF, Viken MK, Sæther H, Flåm ST, Bråthen G, Kampman MT, Midgard R, Christensen M, Rognerud A, Kerty E, Gilhus NE, Tallaksen CM, Lie BA, Harbo HF
PLoS One 2012;7(5):e36603. Epub 2012 May 9 doi: 10.1371/journal.pone.0036603. PMID: 22590574Free PMC Article

Prognosis

GABAA receptor and anti-titin antibody encephalitis in a patient with thymoma.
Tappatà M, Giannoccaro MP, Romoli M, Testoni S, Arnone G, Piccolo L, Solli P, Zaniboni A, Naldi F, Moghadam KK, Nannini N, Damiani S, Liguori R, Zini A
Neurol Sci 2022 Sep;43(9):5633-5636. Epub 2022 Jun 16 doi: 10.1007/s10072-022-06186-6. PMID: 35708792
Paraneoplastic neurological syndromes with onconeural antibodies: A single center retrospective study.
Oliveira V, Videira G, Samões R, Carneiro P, Neves E, Santos E
J Neurol Sci 2020 Nov 15;418:117103. Epub 2020 Aug 21 doi: 10.1016/j.jns.2020.117103. PMID: 32877801
Late-onset generalized myasthenia gravis: clinical features, treatment, and outcome.
Yildiz Celik S, Durmus H, Yilmaz V, Saruhan Direskeneli G, Gulsen Parman Y, Serdaroglu Oflazer P, Deymeer F
Acta Neurol Belg 2020 Feb;120(1):133-140. Epub 2019 Dec 6 doi: 10.1007/s13760-019-01252-x. PMID: 31811563
Screening for anti-titin antibodies in patients with various paraneoplastic neurological syndromes.
Berger B, Stich O, Labeit S, Rauer S
J Neuroimmunol 2016 Jun 15;295-296:18-20. Epub 2016 Apr 13 doi: 10.1016/j.jneuroim.2016.04.004. PMID: 27235344
Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis.
Wang R, Li J, Wang M, Hao H, Chen X, Li R, Zhu X
Br J Dermatol 2015 Apr;172(4):968-75. Epub 2015 Mar 5 doi: 10.1111/bjd.13525. PMID: 25388377

Clinical prediction guides

Unique association of anti-GABA(A) receptor encephalitis and myasthenia gravis in a patient with type A thymoma.
Ouyang S, Wu X, Zhan Q, Wu F, Tan H, Duan W, Zeng Q, Gu W, Lu W, Yin W
Neurol Sci 2024 May;45(5):2203-2209. Epub 2023 Dec 5 doi: 10.1007/s10072-023-07239-0. PMID: 38051411
Late-onset generalized myasthenia gravis: clinical features, treatment, and outcome.
Yildiz Celik S, Durmus H, Yilmaz V, Saruhan Direskeneli G, Gulsen Parman Y, Serdaroglu Oflazer P, Deymeer F
Acta Neurol Belg 2020 Feb;120(1):133-140. Epub 2019 Dec 6 doi: 10.1007/s13760-019-01252-x. PMID: 31811563
Screening for anti-titin antibodies in patients with various paraneoplastic neurological syndromes.
Berger B, Stich O, Labeit S, Rauer S
J Neuroimmunol 2016 Jun 15;295-296:18-20. Epub 2016 Apr 13 doi: 10.1016/j.jneuroim.2016.04.004. PMID: 27235344
The occurrence of anti-titin antibodies and thymomas: a population survey of MG 1970-1999.
Somnier FE, Engel PJ
Neurology 2002 Jul 9;59(1):92-8. doi: 10.1212/wnl.59.1.92. PMID: 12105313
Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro.
Rücker-Martin C, Pecker F, Godreau D, Hatem SN
Cardiovasc Res 2002 Jul;55(1):38-52. doi: 10.1016/s0008-6363(02)00338-3. PMID: 12062707

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...