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Secondary hypereosinophilic syndrome

MedGen UID:
Concept ID:
Disease or Syndrome
Synonyms: HES-R; HES-R - hypereosinophilic syndrome reactive; Hypereosinophilic syndrome due to disease; Reactive hypereosinophilic syndrome; reactive hypereosinophilic syndrome; Secondary HES; secondary HES; secondary hypereosinophilic syndrome
SNOMED CT: Hypereosinophilic syndrome due to disease (1237617004); Secondary hypereosinophilic syndrome (1237617004); HES-R - hypereosinophilic syndrome reactive (1237617004); Reactive hypereosinophilic syndrome (1237617004)
Monarch Initiative: MONDO:0017834
Orphanet: ORPHA314962


A rare hypereosinophilic syndrome with characteristics of hypereosinophilia produced by reactive/non-clonal eosinophils secondary to an underlying medical condition and persisting for at least six months. The disorder can derive from non-neoplastic conditions (such as chronic infections and infestations, allergic reactions, intoxications, or autoimmune and chronic inflammatory disorders) or from neoplasms including non-myeloid malignancies, among others. It is associated with signs of organ infiltration, dysfunction and damage. Clinical manifestations are highly variable depending on the organ systems involved, and most commonly include dermatologic, pulmonary, cardiac, gastrointestinal, and cerebral manifestations. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary hypereosinophilic syndrome

Professional guidelines


Rosenberg CE, Fulkerson PC, Williams KW
J Allergy Clin Immunol Pract 2022 May;10(5):1131-1138. Epub 2022 Feb 15 doi: 10.1016/j.jaip.2022.02.007. PMID: 35181546
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623

Recent clinical studies


Reguero-Del Cura L, Pérez-Paredes MG, Cortés-Vázquez MA, López-Sundh AE, González-Vela MC, Gómez-Fernández C, González-López MA
Australas J Dermatol 2021 May;62(2):213-216. Epub 2021 Jan 9 doi: 10.1111/ajd.13531. PMID: 33421095


Crapé L, Strubbe B, Cesmeli E, de Clerck F
Acta Gastroenterol Belg 2019 Oct-Dec;82(4):532-535. PMID: 31950810


Nakamura M, Otsuka T, Kumagai M, Arisawa T
Intern Med 2022 Jan 15;61(2):267-269. Epub 2021 Jul 10 doi: 10.2169/internalmedicine.7725-21. PMID: 34248122Free PMC Article

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