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Impaired renal tubular reabsorption of low molecular weight protein

MedGen UID:
1815093
Concept ID:
C5706187
Finding
Synonym: Increased low molecular weight protein excretion
 
HPO: HP:0034356

Definition

Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired renal tubular reabsorption of low molecular weight protein

Professional guidelines

PubMed

Branten AJ, Klasen IS, Wetzels JF
Clin Nephrol 2002 Oct;58(4):267-74. doi: 10.5414/cnp58267. PMID: 12400841

Recent clinical studies

Etiology

Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
Awad H, el-Safty I, el-Barbary M, Imam S
Am J Med Sci 2002 Nov;324(5):261-6. doi: 10.1097/00000441-200211000-00005. PMID: 12449447
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054
Savolainen H
Ren Fail 1995 Sep;17(5):483-7. doi: 10.3109/08860229509037613. PMID: 8570861
Gatta A, Amodio P, Frigo A, Merkel C, Milani L, Zuin R, Ruol A
Eur J Clin Invest 1981 Jun;11(3):239-43. doi: 10.1111/j.1365-2362.1981.tb01847.x. PMID: 6168470

Diagnosis

Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R
J Am Soc Nephrol 2022 Apr;33(4):732-745. Epub 2022 Feb 11 doi: 10.1681/ASN.2021101312. PMID: 35149593Free PMC Article
Bökenkamp A
Pediatr Nephrol 2020 Apr;35(4):533-541. Epub 2020 Jan 10 doi: 10.1007/s00467-019-04454-w. PMID: 31925536Free PMC Article
Johri N, Jacquillet G, Unwin R
Biometals 2010 Oct;23(5):783-92. Epub 2010 Mar 31 doi: 10.1007/s10534-010-9328-y. PMID: 20354761
Awad H, el-Safty I, el-Barbary M, Imam S
Am J Med Sci 2002 Nov;324(5):261-6. doi: 10.1097/00000441-200211000-00005. PMID: 12449447
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

Therapy

Awad H, el-Safty I, el-Barbary M, Imam S
Am J Med Sci 2002 Nov;324(5):261-6. doi: 10.1097/00000441-200211000-00005. PMID: 12449447
Branten AJ, Klasen IS, Wetzels JF
Clin Nephrol 2002 Oct;58(4):267-74. doi: 10.5414/cnp58267. PMID: 12400841
Dobrota M, Powell CJ, Holtz E, Wallin A, Vik H
Acta Radiol Suppl 1995;399:196-203. doi: 10.1177/0284185195036s39924. PMID: 8610515
Rossi R, Helmchen U, Schellong G
Eur J Pediatr 1992 May;151(5):384-7. doi: 10.1007/BF02113264. PMID: 1396897
Trollfors B
Ups J Med Sci 1985;90(1):31-6. doi: 10.3109/03009738509178635. PMID: 3890318

Prognosis

Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R
J Am Soc Nephrol 2022 Apr;33(4):732-745. Epub 2022 Feb 11 doi: 10.1681/ASN.2021101312. PMID: 35149593Free PMC Article
Bazzi C, Rizza V, Olivieri G, Casellato D, D'Amico G
J Nephrol 2015 Oct;28(5):541-8. Epub 2014 Sep 17 doi: 10.1007/s40620-014-0139-z. PMID: 25227764
Awad H, el-Safty I, el-Barbary M, Imam S
Am J Med Sci 2002 Nov;324(5):261-6. doi: 10.1097/00000441-200211000-00005. PMID: 12449447
Teppo AM, Honkanen E, Ahonen J, Grönhagen-Riska C
Transplantation 2000 Oct 27;70(8):1154-9. doi: 10.1097/00007890-200010270-00005. PMID: 11063333
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

Clinical prediction guides

Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R
J Am Soc Nephrol 2022 Apr;33(4):732-745. Epub 2022 Feb 11 doi: 10.1681/ASN.2021101312. PMID: 35149593Free PMC Article
Kumari M, Sharma R, Pandey G, Ecelbarger CM, Mishra P, Tiwari S
J Cell Biochem 2019 Jun;120(6):10688-10696. Epub 2019 Jan 15 doi: 10.1002/jcb.28359. PMID: 30644120
Bazzi C, Rizza V, Olivieri G, Casellato D, D'Amico G
J Nephrol 2015 Oct;28(5):541-8. Epub 2014 Sep 17 doi: 10.1007/s40620-014-0139-z. PMID: 25227764
Awad H, el-Safty I, el-Barbary M, Imam S
Am J Med Sci 2002 Nov;324(5):261-6. doi: 10.1097/00000441-200211000-00005. PMID: 12449447
Turner G, Coates P, Warren S, Woodhead JS, Peters JR
Acta Diabetol 1997 Mar;34(1):27-32. doi: 10.1007/s005920050061. PMID: 9134054

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