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Oropharyngeal Candidiasis

MedGen UID:
181574
•Concept ID:
C0919659
•
Disease or Syndrome

Definition

Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Candidiasis

Professional guidelines

PubMed

Human Oropharyngeal Candidiasis: From Etiology to Current Treatment.
Qadir MI, Bashir H, Ahmad MH
Crit Rev Immunol 2023;43(3):15-24. doi: 10.1615/CritRevImmunol.2023049730. PMID: 37824374
Treatment strategies for oropharyngeal candidiasis.
Laudenbach JM, Epstein JB
Expert Opin Pharmacother 2009 Jun;10(9):1413-21. doi: 10.1517/14656560902952854. PMID: 19505211
Candidiasis: pathogenesis, clinical characteristics, and treatment.
Appleton SS
J Calif Dent Assoc 2000 Dec;28(12):942-8. PMID: 11323949

Recent clinical studies

Etiology

Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin.
Launder D, Dillon JT, Wuescher LM, Glanz T, Abdul-Aziz N, Yi EM, Naglik JR, Worth RG, Conti HR
Mucosal Immunol 2024 Apr;17(2):182-200. Epub 2024 Jan 20 doi: 10.1016/j.mucimm.2024.01.003. PMID: 38246240Free PMC Article
The safety of long-term use of inhaled corticosteroids in patients with asthma: A systematic review and meta-analysis.
Shang W, Wang G, Wang Y, Han D
Clin Immunol 2022 Mar;236:108960. Epub 2022 Feb 24 doi: 10.1016/j.clim.2022.108960. PMID: 35218965
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2013 Nov 8;2013:1304. PMID: 24209593Free PMC Article
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348417Free PMC Article
Posaconazole: when and how? The clinician's view.
Katragkou A, Tsikopoulou F, Roilides E, Zaoutis TE
Mycoses 2012 Mar;55(2):110-22. Epub 2011 Jul 18 doi: 10.1111/j.1439-0507.2011.02061.x. PMID: 21762211

Diagnosis

Oropharyngeal candidiasis #147.
Rosielle DA
J Palliat Med 2010 Dec;13(12):1485-6. doi: 10.1089/jpm.2010.9753. PMID: 21155644
Oropharyngeal candidiasis.
Pankhurst C
Clin Evid 2002 Jun;(7):1248-62. PMID: 12230743
The role of yeasts other than Candida albicans in oropharyngeal candidiasis.
Redding SW
Curr Opin Infect Dis 2001 Dec;14(6):673-7. doi: 10.1097/00001432-200112000-00002. PMID: 11964883
Antifungal susceptibility testing: technical advances and potential clinical applications.
Pfaller MA, Rex JH, Rinaldi MG
Clin Infect Dis 1997 May;24(5):776-84. doi: 10.1093/clinids/24.5.776. PMID: 9142769
Inhaled corticosteroids in children. Is there a 'safe' dosage?
Boner AL, Piacentini GL
Drug Saf 1993 Jul;9(1):9-20. doi: 10.2165/00002018-199309010-00002. PMID: 8347293

Therapy

Human Oropharyngeal Candidiasis: From Etiology to Current Treatment.
Qadir MI, Bashir H, Ahmad MH
Crit Rev Immunol 2023;43(3):15-24. doi: 10.1615/CritRevImmunol.2023049730. PMID: 37824374
Miconazole mucoadhesive tablets: a novel delivery system.
Vazquez JA, Sobel JD
Clin Infect Dis 2012 May;54(10):1480-4. Epub 2012 Apr 10 doi: 10.1093/cid/cis205. PMID: 22495075
Posaconazole: when and how? The clinician's view.
Katragkou A, Tsikopoulou F, Roilides E, Zaoutis TE
Mycoses 2012 Mar;55(2):110-22. Epub 2011 Jul 18 doi: 10.1111/j.1439-0507.2011.02061.x. PMID: 21762211
Posaconazole: a new broad-spectrum antifungal agent.
Kwon DS, Mylonakis E
Expert Opin Pharmacother 2007 Jun;8(8):1167-78. doi: 10.1517/14656566.8.8.1167. PMID: 17516880
Salmeterol/fluticasone propionate combination.
Spencer CM, Jarvis B
Drugs 1999 Jun;57(6):933-40; discussion 941-3. doi: 10.2165/00003495-199957060-00010. PMID: 10400406

Prognosis

An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses.
Hampe IAI, Friedman J, Edgerton M, Morschhäuser J
PLoS Pathog 2017 Sep;13(9):e1006655. Epub 2017 Sep 27 doi: 10.1371/journal.ppat.1006655. PMID: 28953977Free PMC Article
Posaconazole: when and how? The clinician's view.
Katragkou A, Tsikopoulou F, Roilides E, Zaoutis TE
Mycoses 2012 Mar;55(2):110-22. Epub 2011 Jul 18 doi: 10.1111/j.1439-0507.2011.02061.x. PMID: 21762211
Prevalence of esophageal candidiasis among patients treated with inhaled fluticasone propionate.
Kanda N, Yasuba H, Takahashi T, Mizuhara Y, Yamazaki S, Imada Y, Izumi Y, Kobayashi Y, Yamashita K, Kita H, Tamada T, Chiba T
Am J Gastroenterol 2003 Oct;98(10):2146-8. doi: 10.1111/j.1572-0241.2003.07626.x. PMID: 14572559
Is antifungal susceptibility testing useful in guiding fluconazole therapy?
Ghannoum MA
Clin Infect Dis 1996 May;22 Suppl 2:S161-5. doi: 10.1093/clinids/22.supplement_2.s161. PMID: 8722845
Candidiasis.
Meunier F
Eur J Clin Microbiol Infect Dis 1989 May;8(5):438-47. doi: 10.1007/BF01964058. PMID: 2502408

Clinical prediction guides

Genetic diversity and antifungal susceptibility of Candida albicans isolates from Iranian HIV-infected patients with oral candidiasis.
Tamai IA, Pakbin B, Fasaei BN
BMC Res Notes 2021 Mar 10;14(1):93. doi: 10.1186/s13104-021-05498-8. PMID: 33691787Free PMC Article
Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans.
Dahal GP, Launder D, McKeone KMM, Hunter JP, Conti HR, Viola RE
Drug Dev Res 2020 Sep;81(6):736-744. Epub 2020 May 8 doi: 10.1002/ddr.21682. PMID: 32383780
Iron binding modulates candidacidal properties of salivary histatin 5.
Puri S, Li R, Ruszaj D, Tati S, Edgerton M
J Dent Res 2015 Jan;94(1):201-8. Epub 2014 Nov 3 doi: 10.1177/0022034514556709. PMID: 25365968Free PMC Article
Miconazole mucoadhesive tablets: a novel delivery system.
Vazquez JA, Sobel JD
Clin Infect Dis 2012 May;54(10):1480-4. Epub 2012 Apr 10 doi: 10.1093/cid/cis205. PMID: 22495075
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348417Free PMC Article

Recent systematic reviews

Inhaled corticosteroids versus placebo  for stable chronic obstructive pulmonary disease.
Yang IA, Ferry OR, Clarke MS, Sim EH, Fong KM
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD002991. doi: 10.1002/14651858.CD002991.pub4. PMID: 36971693Free PMC Article
The safety of long-term use of inhaled corticosteroids in patients with asthma: A systematic review and meta-analysis.
Shang W, Wang G, Wang Y, Han D
Clin Immunol 2022 Mar;236:108960. Epub 2022 Feb 24 doi: 10.1016/j.clim.2022.108960. PMID: 35218965
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2013 Nov 8;2013:1304. PMID: 24209593Free PMC Article
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348417Free PMC Article
Candidiasis (oropharyngeal).
Pankhurst CL
BMJ Clin Evid 2009 Mar 18;2009 PMID: 19445752Free PMC Article

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