U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Digestive System Intraepithelial Neoplasia

MedGen UID:
181583
Concept ID:
C0920207
Neoplastic Process
Synonyms: Gastrointestinal Intraepithelial Neoplasia; Gastrointestinal Noninvasive Neoplasia; Gastrointestinal System Intraepithelial Neoplasia

Definition

A non-invasive neoplastic process that affects the epithelium of any part of the digestive system. It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Intraepithelial Neoplasia

Professional guidelines

PubMed

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Li S, Xie K
Biochim Biophys Acta Rev Cancer 2022 Mar;1877(2):188698. Epub 2022 Feb 15 doi: 10.1016/j.bbcan.2022.188698. PMID: 35176433
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Wang L, Xie D, Wei D
Methods Mol Biol 2019;1882:299-308. doi: 10.1007/978-1-4939-8879-2_26. PMID: 30378064
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Diagnosis

Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Shaib YH, Rugge M, Graham DY, Genta RM
Clin Gastroenterol Hepatol 2013 Nov;11(11):1374-84. Epub 2013 Apr 10 doi: 10.1016/j.cgh.2013.03.019. PMID: 23583466Free PMC Article
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738
Dunbar K, Canto M
Curr Opin Gastroenterol 2008 Sep;24(5):631-7. doi: 10.1097/MOG.0b013e32830c91c7. PMID: 19122507
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Therapy

Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
N Engl J Med 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497. PMID: 17494927
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M
Surg Today 2018 Jan;48(1):9-17. Epub 2017 Mar 4 doi: 10.1007/s00595-017-1501-2. PMID: 28260136
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Recent systematic reviews

Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE
Lancet Oncol 2012 May;13(5):487-500. Epub 2012 Mar 23 doi: 10.1016/S1470-2045(12)70080-3. PMID: 22445259

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...