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Digestive System Intraepithelial Neoplasia

MedGen UID:
181583
•Concept ID:
C0920207
•
Neoplastic Process
Synonyms: Gastrointestinal Intraepithelial Neoplasia; Gastrointestinal Noninvasive Neoplasia; Gastrointestinal System Intraepithelial Neoplasia

Definition

A non-invasive neoplastic process that affects the epithelium of any part of the digestive system. It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Intraepithelial Neoplasia

Professional guidelines

PubMed

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Ductal metaplasia in pancreas.
Li S, Xie K
Biochim Biophys Acta Rev Cancer 2022 Mar;1877(2):188698. Epub 2022 Feb 15 doi: 10.1016/j.bbcan.2022.188698. PMID: 35176433
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic Acinar-to-Ductal Metaplasia and Pancreatic Cancer.
Wang L, Xie D, Wei D
Methods Mol Biol 2019;1882:299-308. doi: 10.1007/978-1-4939-8879-2_26. PMID: 30378064
An overview of anal intraepithelial neoplasia.
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Diagnosis

An overview of anal intraepithelial neoplasia.
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
Management of gastric polyps: an endoscopy-based approach.
Shaib YH, Rugge M, Graham DY, Genta RM
Clin Gastroenterol Hepatol 2013 Nov;11(11):1374-84. Epub 2013 Apr 10 doi: 10.1016/j.cgh.2013.03.019. PMID: 23583466Free PMC Article
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738
Confocal endomicroscopy.
Dunbar K, Canto M
Curr Opin Gastroenterol 2008 Sep;24(5):631-7. doi: 10.1097/MOG.0b013e32830c91c7. PMID: 19122507
Anal intraepithelial neoplasia.
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Cells of origin of pancreatic neoplasms.
Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M
Surg Today 2018 Jan;48(1):9-17. Epub 2017 Mar 4 doi: 10.1007/s00595-017-1501-2. PMID: 28260136
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Recent systematic reviews

Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Efficacy and Safety of Multiband Mucosectomy Versus Cap-assisted Endoscopic Resection For Early Esophageal Cancer and Precancerous Lesions: A Systematic Review and Meta-Analysis.
Dan X, Lv XH, San ZJ, Geng S, Wang YQ, Li SH, Xie HH
Surg Laparosc Endosc Percutan Tech 2019 Oct;29(5):313-320. doi: 10.1097/SLE.0000000000000711. PMID: 31436649
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: a systematic review and meta-analysis.
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis.
Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE
Lancet Oncol 2012 May;13(5):487-500. Epub 2012 Mar 23 doi: 10.1016/S1470-2045(12)70080-3. PMID: 22445259

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