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Neonatal Leukopenia

MedGen UID:
181745
•Concept ID:
C0947700
•
Disease or Syndrome

Definition

Leukopenia that occurs in the neonatal period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Leukopenia

Professional guidelines

PubMed

Chromosome 22q11.2 Deletion (DiGeorge Syndrome): Immunologic Features, Diagnosis, and Management.
Biggs SE, Gilchrist B, May KR
Curr Allergy Asthma Rep 2023 Apr;23(4):213-222. Epub 2023 Mar 10 doi: 10.1007/s11882-023-01071-4. PMID: 36897497Free PMC Article
Newborn Screening for Severe Combined Immunodeficiency.
Taki M, Miah T, Secord E
Immunol Allergy Clin North Am 2021 Nov;41(4):543-553. doi: 10.1016/j.iac.2021.07.007. PMID: 34602227
Management of Invasive Fungal Disease in Neonates and Children.
Ferreras-Antolín L, Sharland M, Warris A
Pediatr Infect Dis J 2019 Jun;38(6S Suppl 1):S2-S6. doi: 10.1097/INF.0000000000002317. PMID: 31205236Free PMC Article

Recent clinical studies

Etiology

Management of Invasive Fungal Disease in Neonates and Children.
Ferreras-Antolín L, Sharland M, Warris A
Pediatr Infect Dis J 2019 Jun;38(6S Suppl 1):S2-S6. doi: 10.1097/INF.0000000000002317. PMID: 31205236Free PMC Article
Clinico-haematological profile of patients with bicytopenia.
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Valganciclovir for symptomatic congenital cytomegalovirus disease.
Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, Arav-Boger R, Michaels MG, Ashouri N, Englund JA, Estrada B, Jacobs RF, Romero JR, Sood SK, Whitworth MS, Abzug MJ, Caserta MT, Fowler S, Lujan-Zilbermann J, Storch GA, DeBiasi RL, Han JY, Palmer A, Weiner LB, Bocchini JA, Dennehy PH, Finn A, Griffiths PD, Luck S, Gutierrez K, Halasa N, Homans J, Shane AL, Sharland M, Simonsen K, Vanchiere JA, Woods CR, Sabo DL, Aban I, Kuo H, James SH, Prichard MN, Griffin J, Giles D, Acosta EP, Whitley RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
N Engl J Med 2015 Mar 5;372(10):933-43. doi: 10.1056/NEJMoa1404599. PMID: 25738669Free PMC Article
Maternal preeclampsia and neonatal outcomes.
Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ
J Pregnancy 2011;2011:214365. Epub 2011 Apr 4 doi: 10.1155/2011/214365. PMID: 21547086Free PMC Article

Diagnosis

Pediatric Fever.
Rose E
Emerg Med Clin North Am 2021 Aug;39(3):627-639. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.011. PMID: 34215406
Approach to primary immunodeficiency.
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396
Clinico-haematological profile of patients with bicytopenia.
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Maternal preeclampsia and neonatal outcomes.
Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ
J Pregnancy 2011;2011:214365. Epub 2011 Apr 4 doi: 10.1155/2011/214365. PMID: 21547086Free PMC Article

Therapy

Pediatric Fever.
Rose E
Emerg Med Clin North Am 2021 Aug;39(3):627-639. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.011. PMID: 34215406
Management of Invasive Fungal Disease in Neonates and Children.
Ferreras-Antolín L, Sharland M, Warris A
Pediatr Infect Dis J 2019 Jun;38(6S Suppl 1):S2-S6. doi: 10.1097/INF.0000000000002317. PMID: 31205236Free PMC Article
Clinico-haematological profile of patients with bicytopenia.
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Valganciclovir for symptomatic congenital cytomegalovirus disease.
Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, Arav-Boger R, Michaels MG, Ashouri N, Englund JA, Estrada B, Jacobs RF, Romero JR, Sood SK, Whitworth MS, Abzug MJ, Caserta MT, Fowler S, Lujan-Zilbermann J, Storch GA, DeBiasi RL, Han JY, Palmer A, Weiner LB, Bocchini JA, Dennehy PH, Finn A, Griffiths PD, Luck S, Gutierrez K, Halasa N, Homans J, Shane AL, Sharland M, Simonsen K, Vanchiere JA, Woods CR, Sabo DL, Aban I, Kuo H, James SH, Prichard MN, Griffin J, Giles D, Acosta EP, Whitley RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
N Engl J Med 2015 Mar 5;372(10):933-43. doi: 10.1056/NEJMoa1404599. PMID: 25738669Free PMC Article

Prognosis

Pediatric Fever.
Rose E
Emerg Med Clin North Am 2021 Aug;39(3):627-639. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.011. PMID: 34215406
Hematological manifestations of SARS-CoV-2 in children.
Kosmeri C, Koumpis E, Tsabouri S, Siomou E, Makis A
Pediatr Blood Cancer 2020 Dec;67(12):e28745. Epub 2020 Oct 3 doi: 10.1002/pbc.28745. PMID: 33009893Free PMC Article
Candidemia in Colombia.
Cortés JA, Ruiz JF, Melgarejo-Moreno LN, Lemos EV
Biomedica 2020 Mar 1;40(1):195-207. doi: 10.7705/biomedica.4400. PMID: 32220174Free PMC Article
Neutropenia in the newborn.
Maheshwari A
Curr Opin Hematol 2014 Jan;21(1):43-9. doi: 10.1097/MOH.0000000000000010. PMID: 24322487Free PMC Article
Neonatal infections.
Greenough A
Curr Opin Pediatr 1996 Feb;8(1):6-10. doi: 10.1097/00008480-199602000-00003. PMID: 8680517

Clinical prediction guides

Treating neutropenia and neutrophil dysfunction in glycogen storage disease type Ib with an SGLT2 inhibitor.
Wortmann SB, Van Hove JLK, Derks TGJ, Chevalier N, Knight V, Koller A, Oussoren E, Mayr JA, van Spronsen FJ, Lagler FB, Gaughan S, Van Schaftingen E, Veiga-da-Cunha M
Blood 2020 Aug 27;136(9):1033-1043. doi: 10.1182/blood.2019004465. PMID: 32294159Free PMC Article
Management of Invasive Fungal Disease in Neonates and Children.
Ferreras-Antolín L, Sharland M, Warris A
Pediatr Infect Dis J 2019 Jun;38(6S Suppl 1):S2-S6. doi: 10.1097/INF.0000000000002317. PMID: 31205236Free PMC Article
Clinico-haematological profile of patients with bicytopenia.
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
How I manage children with neutropenia.
Dale DC
Br J Haematol 2017 Aug;178(3):351-363. Epub 2017 Apr 17 doi: 10.1111/bjh.14677. PMID: 28419427
Valganciclovir for symptomatic congenital cytomegalovirus disease.
Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, Arav-Boger R, Michaels MG, Ashouri N, Englund JA, Estrada B, Jacobs RF, Romero JR, Sood SK, Whitworth MS, Abzug MJ, Caserta MT, Fowler S, Lujan-Zilbermann J, Storch GA, DeBiasi RL, Han JY, Palmer A, Weiner LB, Bocchini JA, Dennehy PH, Finn A, Griffiths PD, Luck S, Gutierrez K, Halasa N, Homans J, Shane AL, Sharland M, Simonsen K, Vanchiere JA, Woods CR, Sabo DL, Aban I, Kuo H, James SH, Prichard MN, Griffin J, Giles D, Acosta EP, Whitley RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
N Engl J Med 2015 Mar 5;372(10):933-43. doi: 10.1056/NEJMoa1404599. PMID: 25738669Free PMC Article

Recent systematic reviews

Malaria in pregnancy in India: a 50-year bird's eye.
Kojom Foko LP, Singh V
Front Public Health 2023;11:1150466. Epub 2023 Oct 19 doi: 10.3389/fpubh.2023.1150466. PMID: 37927870Free PMC Article
Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis.
Jafari M, Pormohammad A, Sheikh Neshin SA, Ghorbani S, Bose D, Alimohammadi S, Basirjafari S, Mohammadi M, Rasmussen-Ivey C, Razizadeh MH, Nouri-Vaskeh M, Zarei M
Rev Med Virol 2021 Sep;31(5):1-16. Epub 2021 Jan 2 doi: 10.1002/rmv.2208. PMID: 33387448Free PMC Article
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.
Estcourt LJ, Stanworth SJ, Hopewell S, Doree C, Trivella M, Massey E
Cochrane Database Syst Rev 2016 Apr 29;4(4):CD005339. doi: 10.1002/14651858.CD005339.pub2. PMID: 27128488Free PMC Article
Systematic review and meta-analysis of the value of clinical features to exclude radiographic pneumonia in febrile neutropenic episodes in children and young people.
Phillips B, Wade R, Westwood M, Riley R, Sutton AJ
J Paediatr Child Health 2012 Aug;48(8):641-8. Epub 2011 Nov 3 doi: 10.1111/j.1440-1754.2011.02211.x. PMID: 22050289
Zygomycosis in children: a systematic review and analysis of reported cases.
Zaoutis TE, Roilides E, Chiou CC, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Prasad PA, Chu JH, Walsh TJ
Pediatr Infect Dis J 2007 Aug;26(8):723-7. doi: 10.1097/INF.0b013e318062115c. PMID: 17848885

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