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Benign male reproductive system neoplasm

MedGen UID:: 181751
•Concept ID:: C0947786
•: Neoplastic Process

Synonyms:	Benign Male Reproductive System Neoplasm; benign male reproductive system neoplasm; benign Male reproductive system neoplasm; Benign Male Reproductive System Tumor; benign Male reproductive system tumor; benign Male reproductive system tumour; male reproductive organ benign neoplasm

Monarch Initiative:	MONDO:0000625

Definition

A neoplasm that arises from the male reproductive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include benign prostate phyllodes tumor, benign Sertoli cell tumor, seminal vesicle cystadenoma, and epididymal adenomatoid tumor. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign male reproductive system neoplasm

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign Genitourinary System Neoplasm
        Benign reproductive system neoplasm
        Benign male reproductive system neoplasm
        Benign neoplasm of epididymis
        Epididymal adenomatoid tumor
        Epididymal Cystadenoma
        Epididymal Papillary Cystadenoma
        Benign neoplasm of penis
        Penile Hemangioma
        Penile Epithelioid Hemangioma
        Penile Leiomyoma
        Penile Lymphangioma
        Penile Myointimoma
        Penile Neurofibroma
        Penile Schwannoma
        Benign neoplasm of prostate
        Benign prostate phyllodes tumor
        Fibroma of prostate
        Prostate Cystadenoma
        Prostate Hemangioma
        Prostate leiomyoma
        Prostatic adenoma
        Benign neoplasm of testis
        Benign testicular sertoli cell tumor
        Testicular Sclerosing Sertoli Cell Tumor
        Testicular Sertoli Cell Tumor, Lipid Rich Variant
        Testicular fibroma
        Testicular Mature Teratoma
        Childhood Testicular Mature Teratoma
        Testicular Dermoid Cyst
        Benign Seminal Vesicle Neoplasm
        Seminal vesicle cystadenoma
        Seminal Vesicle Leiomyoma
        Seminal Vesicle Mammary-Type Myofibroblastoma
        Seminal Vesicle Schwannoma
        Paratesticular Adenomatoid Tumor
        Paratesticular Cellular Angiofibroma
        Paratesticular Deep (Aggressive) Angiomyxoma
        Paratesticular Hemangioma
        Paratesticular Leiomyoma
        Paratesticular lipoma
        Lipoma of spermatic cord
        Paratesticular Mammary-Type Myofibroblastoma
        Paratesticular Rhabdomyoma
        Paratesticular Schwannoma
        Rete testis adenoma

Professional guidelines

PubMed

Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.

Cicero AFG, Allkanjari O, Busetto GM, Cai T, Larganà G, Magri V, Perletti G, Robustelli Della Cuna FS, Russo GI, Stamatiou K, Trinchieri A, Vitalone A
Arch Ital Urol Androl 2019 Oct 2;91(3) doi: 10.4081/aiua.2019.3.139. PMID: 31577095

EAA clinical practice guidelines-gynecomastia evaluation and management.

Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Prostate Cancer in Primary Care.

Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885 Free PMC Article

See all (363)

Recent clinical studies

Etiology

Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics.

Adamaki M, Zoumpourlis V
Pharmacol Ther 2021 Dec;228:107932. Epub 2021 Jun 24 doi: 10.1016/j.pharmthera.2021.107932. PMID: 34174272

Benign mimics of prostate cancer.

Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H
Pathology 2021 Jan;53(1):26-35. Epub 2020 Oct 16 doi: 10.1016/j.pathol.2020.08.006. PMID: 33070957

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.

Comprehensive overview of prostatitis.

Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783

See all (4134)

Diagnosis

Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics.

Adamaki M, Zoumpourlis V
Pharmacol Ther 2021 Dec;228:107932. Epub 2021 Jun 24 doi: 10.1016/j.pharmthera.2021.107932. PMID: 34174272

Prostatic stromal proliferations: a review.

Bostwick DG, Egevad L
Pathology 2021 Jan;53(1):12-25. Epub 2020 Nov 13 doi: 10.1016/j.pathol.2020.09.017. PMID: 33190920

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Comprehensive overview of prostatitis.

Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783

Benign intrascrotal lesions.

Rubenstein RA, Dogra VS, Seftel AD, Resnick MI
J Urol 2004 May;171(5):1765-72. doi: 10.1097/01.ju.0000123083.98845.88. PMID: 15076274

See all (5482)

Therapy

Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics.

Adamaki M, Zoumpourlis V
Pharmacol Ther 2021 Dec;228:107932. Epub 2021 Jun 24 doi: 10.1016/j.pharmthera.2021.107932. PMID: 34174272

Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.

Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T, Bogdanos DP, Goulis DG
Nutrients 2020 Sep 29;12(10) doi: 10.3390/nu12102985. PMID: 33003518 Free PMC Article

Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.

Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.

Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L, Beltran H
Sci Transl Med 2019 Mar 20;11(484) doi: 10.1126/scitranslmed.aav0891. PMID: 30894499 Free PMC Article

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW
Sex Med Rev 2019 Jan;7(1):84-94. Epub 2018 Nov 30 doi: 10.1016/j.sxmr.2018.09.006. PMID: 30503797 Free PMC Article

See all (1386)

Prognosis

Artificial Intelligence and Pathomics: Prostate Cancer.

Azadi Moghadam P, Bashashati A, Goldenberg SL
Urol Clin North Am 2024 Feb;51(1):15-26. Epub 2023 Jul 25 doi: 10.1016/j.ucl.2023.06.001. PMID: 37945099

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Comparative Expression of RAGE and SOX2 in Benign and Malignant Prostatic Lesions.

Aboushousha T, Lashen R, Abdelnaser K, Helal N, Moussa M, Omran Z, Eldahshan S, El Ganzoury H
Asian Pac J Cancer Prev 2019 Feb 26;20(2):615-620. doi: 10.31557/APJCP.2019.20.2.615. PMID: 30806068 Free PMC Article

Prostate Cancer in Primary Care.

Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885 Free PMC Article

Paratesticular mesothelial proliferations.

Churg A
Semin Diagn Pathol 2003 Nov;20(4):272-8. doi: 10.1053/j.semdp.2003.08.003. PMID: 14694980

See all (3102)

Clinical prediction guides

Artificial Intelligence and Pathomics: Prostate Cancer.

Azadi Moghadam P, Bashashati A, Goldenberg SL
Urol Clin North Am 2024 Feb;51(1):15-26. Epub 2023 Jul 25 doi: 10.1016/j.ucl.2023.06.001. PMID: 37945099

SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors.

Liu Z, Xie J, Gao X, Lin Y, Sun M, Sun Y, Peng D, Xie H, Li X, Li Z, Cai T, Chen P, Wu Z, Guo S, Li Y, Zhang Z, Qin Z, Han H, He Z, Liu J, Fu W, Li S, Xia D, Wang X, Deng C, Xu Z, Zhou F, Yao K, Yu W, Ye Y, Liu Z
Int J Surg 2023 Dec 1;109(12):4185-4198. doi: 10.1097/JS9.0000000000000752. PMID: 37738014 Free PMC Article

Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study.

Ström P, Kartasalo K, Olsson H, Solorzano L, Delahunt B, Berney DM, Bostwick DG, Evans AJ, Grignon DJ, Humphrey PA, Iczkowski KA, Kench JG, Kristiansen G, van der Kwast TH, Leite KRM, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, Tsuzuki T, Varma M, Zhou M, Lindberg J, Lindskog C, Ruusuvuori P, Wählby C, Grönberg H, Rantalainen M, Egevad L, Eklund M
Lancet Oncol 2020 Feb;21(2):222-232. Epub 2020 Jan 8 doi: 10.1016/S1470-2045(19)30738-7. PMID: 31926806

Clinical Impact of Circulating Tumor Cells in Patients with Localized Prostate Cancer.

Broncy L, Paterlini-Bréchot P
Cells 2019 Jul 3;8(7) doi: 10.3390/cells8070676. PMID: 31277346 Free PMC Article

Is There Use for FDG-PET in Prostate Cancer?

Jadvar H
Semin Nucl Med 2016 Nov;46(6):502-506. Epub 2016 Sep 3 doi: 10.1053/j.semnuclmed.2016.07.004. PMID: 27825430 Free PMC Article

See all (4012)

Recent systematic reviews

Human papillomavirus and prostate cancer: systematic review and meta-analysis.

Tsydenova IA, Ibragimova MK, Tsyganov MM, Litviakov NV
Sci Rep 2023 Oct 3;13(1):16597. doi: 10.1038/s41598-023-43767-7. PMID: 37789036 Free PMC Article

A systematic review and meta-analysis of artificial intelligence diagnostic accuracy in prostate cancer histology identification and grading.

Morozov A, Taratkin M, Bazarkin A, Rivas JG, Puliatti S, Checcucci E, Belenchon IR, Kowalewski KF, Shpikina A, Singla N, Teoh JYC, Kozlov V, Rodler S, Piazza P, Fajkovic H, Yakimov M, Abreu AL, Cacciamani GE, Enikeev D; Young Academic Urologists (YAU) Working Group in Uro-technology of the European Association of Urology
Prostate Cancer Prostatic Dis 2023 Dec;26(4):681-692. Epub 2023 Apr 25 doi: 10.1038/s41391-023-00673-3. PMID: 37185992

Efficacy of surgical treatment for post-prostatectomy urinary incontinence: a systematic review and network meta-analysis.

Park JJ, Hong Y, Kwon A, Shim SR, Kim JH
Int J Surg 2023 Mar 1;109(3):401-411. doi: 10.1097/JS9.0000000000000170. PMID: 36912884 Free PMC Article

Controversies in Testosterone Therapy.

Twitchell DK, Pastuszak AW, Khera M
Sex Med Rev 2021 Jan;9(1):149-159. Epub 2020 Dec 9 doi: 10.1016/j.sxmr.2020.09.004. PMID: 33309270

Inguinal canal tumors of adulthood.

Vagnoni V, Brunocilla E, Schiavina R, Borghesi M, Passaretti G, Gentile G, Fiorentino M, Martorana G
Anticancer Res 2013 Jun;33(6):2361-8. PMID: 23749883

See all (70)

MedGen

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Benign male reproductive system neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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