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Ovarian adenocarcinoma

MedGen UID:
181757
•Concept ID:
C0948216
•
Neoplastic Process
Synonyms: Adenocarcinoma of Ovary; adenocarcinoma of ovary; Adenocarcinoma of ovary; Adenocarcinoma of the Ovary; adenocarcinoma of the ovary; Ovarian Adenocarcinoma; ovarian adenocarcinoma; ovary adenocarcinoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0002752
Orphanet: ORPHA213504

Definition

An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian adenocarcinoma
Follow this link to review classifications for Ovarian adenocarcinoma in Orphanet.

Professional guidelines

PubMed

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
Pasqua AE, Sharp SY, Chessum NEA, Hayes A, Pellegrino L, Tucker MJ, Miah A, Wilding B, Evans LE, Rye CS, Mok NY, Liu M, Henley AT, Gowan S, De Billy E, Te Poele R, Powers M, Eccles SA, Clarke PA, Raynaud FI, Workman P, Jones K, Cheeseman MD
J Med Chem 2023 Apr 27;66(8):5907-5936. Epub 2023 Apr 5 doi: 10.1021/acs.jmedchem.3c00156. PMID: 37017629Free PMC Article
Tumor-Treating Fields: A fourth modality in cancer treatment, new practice updates.
Arvind R, Chandana SR, Borad MJ, Pennington D, Mody K, Babiker H
Crit Rev Oncol Hematol 2021 Dec;168:103535. Epub 2021 Nov 19 doi: 10.1016/j.critrevonc.2021.103535. PMID: 34808377
cis-Dichlorodiammineplatinum(II) for the treatment of advanced ovarian cancer.
Young RC, Von Hoff DD, Gormley P, Makuch R, Cassidy J, Howser D, Bull JM
Cancer Treat Rep 1979 Sep-Oct;63(9-10):1539-44. PMID: 387224

Recent clinical studies

Etiology

Effect of alpha lipoic acid on epithelial mesenchymal transition in SKOV-3 cells.
Önder E, Çil N, Seçme M, Mete GA
Gene 2024 Jan 20;892:147880. Epub 2023 Oct 7 doi: 10.1016/j.gene.2023.147880. PMID: 37813206
Validation of a New Prognostic Score in Patients with Ovarian Adenocarcinoma.
Trifanescu OG, Mitrica RI, Gales LN, Marinescu SA, Motas N, Trifanescu RA, Rebegea L, Gherghe M, Georgescu DE, Serbanescu GL, Bashar HH, Dragosloveanu S, Cristian DA, Anghel RM
Medicina (Kaunas) 2023 Jan 26;59(2) doi: 10.3390/medicina59020229. PMID: 36837431Free PMC Article
The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary.
Rosendahl M, Haueberg Oester LA, Høgdall CK
Int J Gynecol Cancer 2017 Mar;27(3):430-436. doi: 10.1097/IGC.0000000000000910. PMID: 28060142
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Carcinogenic potential of ovulatory genotoxicity.
Murdoch WJ
Biol Reprod 2005 Oct;73(4):586-90. Epub 2005 Jun 15 doi: 10.1095/biolreprod.105.042622. PMID: 15958727

Diagnosis

Paraneoplastic movement disorders.
McKeon A, Tracy J
Handb Clin Neurol 2024;200:211-227. doi: 10.1016/B978-0-12-823912-4.00004-9. PMID: 38494279
Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma.
Min Y, Park HB, Baek KH, Hwang S
Genes (Basel) 2023 Apr 9;14(4) doi: 10.3390/genes14040886. PMID: 37107644Free PMC Article
Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma.
Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D, Passirani C
Int J Pharm 2022 Oct 15;626:122164. Epub 2022 Sep 8 doi: 10.1016/j.ijpharm.2022.122164. PMID: 36089209
Synchronous Cervical Adenocarcinoma and Ovarian Serous Adenocarcinoma-A Case Report and Literature Review.
Bacalbasa N, Balescu IC, Diaconu C, Dima S, Iliescu L, Vilcu M, Filipescu A, Halmaciu I, Cretoiu D, Brezean I
Medicina (Kaunas) 2020 Mar 29;56(4) doi: 10.3390/medicina56040152. PMID: 32235322Free PMC Article
Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms.
McCluggage WG
J Clin Pathol 2000 May;53(5):327-34. doi: 10.1136/jcp.53.5.327. PMID: 10889812Free PMC Article

Therapy

The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin.
Dellavedova G, Decio A, Formenti L, Albertella MR, Wilson J, Staniszewska AD, Leo E, Giavazzi R, Ghilardi C, Bani MR
Cancer Res Commun 2023 Mar;3(3):489-500. Epub 2023 Mar 27 doi: 10.1158/2767-9764.CRC-22-0423. PMID: 36994441Free PMC Article
Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma.
Idlas P, Ladaycia A, Némati F, Lepeltier E, Pigeon P, Jaouen G, Decaudin D, Passirani C
Int J Pharm 2022 Oct 15;626:122164. Epub 2022 Sep 8 doi: 10.1016/j.ijpharm.2022.122164. PMID: 36089209
MCL1 regulates cell death, tumor growth and chemosensitivity to sabutoclax in ovarian adenocarcinoma.
Li C, Song Y, Li P
Cell Tissue Res 2020 Mar;379(3):625-633. Epub 2019 Nov 21 doi: 10.1007/s00441-019-03105-8. PMID: 31754782
Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition.
Thibault B, Castells M, Delord JP, Couderc B
Cancer Metastasis Rev 2014 Mar;33(1):17-39. doi: 10.1007/s10555-013-9456-2. PMID: 24357056
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609

Prognosis

Paraneoplastic movement disorders.
McKeon A, Tracy J
Handb Clin Neurol 2024;200:211-227. doi: 10.1016/B978-0-12-823912-4.00004-9. PMID: 38494279
ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles.
Cardeñes B, Clares I, Bezos T, Toribio V, López-Martín S, Rocha A, Peinado H, Yáñez-Mó M, Cabañas C
Int J Mol Sci 2022 May 20;23(10) doi: 10.3390/ijms23105753. PMID: 35628559Free PMC Article
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS
BMC Med 2020 Aug 18;18(1):236. doi: 10.1186/s12916-020-01684-w. PMID: 32807164Free PMC Article
Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition.
Thibault B, Castells M, Delord JP, Couderc B
Cancer Metastasis Rev 2014 Mar;33(1):17-39. doi: 10.1007/s10555-013-9456-2. PMID: 24357056
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Chen PX, Li QY, Yang Z
Ann Diagn Pathol 2013 Oct;17(5):425-9. Epub 2013 May 23 doi: 10.1016/j.anndiagpath.2013.01.005. PMID: 23707658

Clinical prediction guides

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
Pasqua AE, Sharp SY, Chessum NEA, Hayes A, Pellegrino L, Tucker MJ, Miah A, Wilding B, Evans LE, Rye CS, Mok NY, Liu M, Henley AT, Gowan S, De Billy E, Te Poele R, Powers M, Eccles SA, Clarke PA, Raynaud FI, Workman P, Jones K, Cheeseman MD
J Med Chem 2023 Apr 27;66(8):5907-5936. Epub 2023 Apr 5 doi: 10.1021/acs.jmedchem.3c00156. PMID: 37017629Free PMC Article
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS
BMC Med 2020 Aug 18;18(1):236. doi: 10.1186/s12916-020-01684-w. PMID: 32807164Free PMC Article
The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary.
Rosendahl M, Haueberg Oester LA, Høgdall CK
Int J Gynecol Cancer 2017 Mar;27(3):430-436. doi: 10.1097/IGC.0000000000000910. PMID: 28060142
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Chen PX, Li QY, Yang Z
Ann Diagn Pathol 2013 Oct;17(5):425-9. Epub 2013 May 23 doi: 10.1016/j.anndiagpath.2013.01.005. PMID: 23707658

Recent systematic reviews

Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609

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