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Oppositional defiant disorder

MedGen UID:
18178
Concept ID:
C0029121
Mental or Behavioral Dysfunction
Synonym: Oppositional defiant disorder (disease)
SNOMED CT: Oppositional defiant disorder (18941000)
 
HPO: HP:0010865
Monarch Initiative: MONDO:0000495

Definition

An enduring pattern of uncooperative, defiant, and hostile behavior towards authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Oppositional defiant disorder

Conditions with this feature

5p partial monosomy syndrome
MedGen UID:
41345
Concept ID:
C0010314
Disease or Syndrome
Cri-du-chat syndrome was first described by Lejeune et al. (1963) as a hereditary congenital syndrome associated with deletion of part of the short arm of chromosome 5. The deletions can vary in size from extremely small and involving only band 5p15.2 to the entire short arm. Although the majority of deletions arise as new mutations, approximately 12% result from unbalanced segregation of translocations or recombination involving a pericentric inversion in one of the parents.
Mucopolysaccharidosis, MPS-III-D
MedGen UID:
88602
Concept ID:
C0086650
Disease or Syndrome
Mucopolysaccharidosis type III (MPS III) is a multisystem lysosomal storage disease characterized by progressive central nervous system degeneration manifest as severe intellectual disability (ID), developmental regression, and other neurologic manifestations including autism spectrum disorder (ASD), behavioral problems, and sleep disturbances. Disease onset is typically before age ten years. Disease course may be rapidly or slowly progressive; some individuals with an extremely attenuated disease course present in mid-to-late adulthood with early-onset dementia with or without a history of ID. Systemic manifestations can include musculoskeletal problems (joint stiffness, contractures, scoliosis, and hip dysplasia), hearing loss, respiratory tract and sinopulmonary infections, and cardiac disease (valvular thickening, defects in the cardiac conduction system). Neurologic decline is seen in all affected individuals; however, clinical severity varies within and among the four MPS III subtypes (defined by the enzyme involved) and even among members of the same family. Death usually occurs in the second or third decade of life secondary to neurologic regression or respiratory tract infections.
Chromosome 1p36 deletion syndrome
MedGen UID:
334629
Concept ID:
C1842870
Disease or Syndrome
The constitutional deletion of chromosome 1p36 results in a syndrome with multiple congenital anomalies and mental retardation (Shapira et al., 1997). Monosomy 1p36 is the most common terminal deletion syndrome in humans, occurring in 1 in 5,000 births (Shaffer and Lupski, 2000; Heilstedt et al., 2003). See also neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH; 616975), which shows overlapping features and is caused by heterozygous mutation in the RERE gene (605226) on proximal chromosome 1p36. See also Radio-Tartaglia syndrome (RATARS; 619312), caused by mutation in the SPEN gene (613484) on chromosome 1p36, which shows overlapping features.
Coenzyme q10 deficiency, primary, 9
MedGen UID:
1740444
Concept ID:
C5436638
Disease or Syndrome
Coenzyme Q10 deficiency-9 (COQ10D9) is an autosomal recessive disorder characterized by onset of cerebellar ataxia associated with cerebellar atrophy in the first decade of life. Some patients may have additional neurologic signs and symptoms, including intellectual disability and seizures. Treatment with CoQ10 may offer clinical benefit (summary by Malicdan et al., 2018). For a general phenotypic description and a discussion of genetic heterogeneity of primary coenzyme Q10 deficiency, see COQ10D1 (607426).

Recent clinical studies

Etiology

Hawes DJ, Gardner F, Dadds MR, Frick PJ, Kimonis ER, Burke JD, Fairchild G
Nat Rev Dis Primers 2023 Jun 22;9(1):31. doi: 10.1038/s41572-023-00441-6. PMID: 37349322
Burke JD, Evans SC, Carlson GA
Child Adolesc Ment Health 2022 Sep;27(3):297-299. Epub 2022 Jul 22 doi: 10.1111/camh.12588. PMID: 35869580
DeLisi M, Drury AJ, Elbert MJ
Compr Psychiatry 2019 Jul;92:1-6. Epub 2019 Apr 30 doi: 10.1016/j.comppsych.2019.04.001. PMID: 31079021
Riley M, Ahmed S, Locke A
Am Fam Physician 2016 Apr 1;93(7):586-91. PMID: 27035043
Hamilton SS, Armando J
Am Fam Physician 2008 Oct 1;78(7):861-6. PMID: 18841736

Diagnosis

Hawes DJ, Gardner F, Dadds MR, Frick PJ, Kimonis ER, Burke JD, Fairchild G
Nat Rev Dis Primers 2023 Jun 22;9(1):31. doi: 10.1038/s41572-023-00441-6. PMID: 37349322
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Riley M, Ahmed S, Locke A
Am Fam Physician 2016 Apr 1;93(7):586-91. PMID: 27035043
Pringsheim T, Hirsch L, Gardner D, Gorman DA
Can J Psychiatry 2015 Feb;60(2):42-51. doi: 10.1177/070674371506000202. PMID: 25886655Free PMC Article
Hamilton SS, Armando J
Am Fam Physician 2008 Oct 1;78(7):861-6. PMID: 18841736

Therapy

Pouchon A, Nasserdine R, Dondé C, Bertrand A, Polosan M, Bioulac S
Expert Opin Pharmacother 2023 Sep-Dec;24(13):1497-1509. Epub 2023 Jun 21 doi: 10.1080/14656566.2023.2224920. PMID: 37300473
Li F, Cui Y, Li Y, Guo L, Ke X, Liu J, Luo X, Zheng Y, Leckman JF
J Child Psychol Psychiatry 2022 Jan;63(1):34-46. Epub 2021 May 21 doi: 10.1111/jcpp.13445. PMID: 34019305
Johnson M, Åsberg Johnels J, Östlund S, Cedergren K, Omanovic Z, Hjalmarsson K, Jakobsson K, Högstedt J, Billstedt E
J Psychiatr Res 2021 Oct;142:204-209. Epub 2021 Aug 2 doi: 10.1016/j.jpsychires.2021.07.055. PMID: 34375772
Pringsheim T, Hirsch L, Gardner D, Gorman DA
Can J Psychiatry 2015 Feb;60(2):42-51. doi: 10.1177/070674371506000202. PMID: 25886655Free PMC Article
Zwi M, Jones H, Thorgaard C, York A, Dennis JA
Cochrane Database Syst Rev 2011 Dec 7;2011(12):CD003018. doi: 10.1002/14651858.CD003018.pub3. PMID: 22161373Free PMC Article

Prognosis

Racz SJ, McMahon RJ, Gudmundsen G, McCauley E, Vander Stoep A
Dev Psychopathol 2023 May;35(2):730-748. Epub 2022 Jan 25 doi: 10.1017/S0954579421001875. PMID: 35074036Free PMC Article
Raine A, Ling S, Streicher W, Liu J
Psychiatry Res 2022 Oct;316:114744. Epub 2022 Jul 23 doi: 10.1016/j.psychres.2022.114744. PMID: 35961152Free PMC Article
Johnson M, Åsberg Johnels J, Östlund S, Cedergren K, Omanovic Z, Hjalmarsson K, Jakobsson K, Högstedt J, Billstedt E
J Psychiatr Res 2021 Oct;142:204-209. Epub 2021 Aug 2 doi: 10.1016/j.jpsychires.2021.07.055. PMID: 34375772
Burke JD, Johnston OG, Butler EJ
Child Adolesc Psychiatr Clin N Am 2021 Jul;30(3):637-647. doi: 10.1016/j.chc.2021.04.012. PMID: 34053691
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635

Clinical prediction guides

Racz SJ, McMahon RJ, Gudmundsen G, McCauley E, Vander Stoep A
Dev Psychopathol 2023 May;35(2):730-748. Epub 2022 Jan 25 doi: 10.1017/S0954579421001875. PMID: 35074036Free PMC Article
Raine A, Ling S, Streicher W, Liu J
Psychiatry Res 2022 Oct;316:114744. Epub 2022 Jul 23 doi: 10.1016/j.psychres.2022.114744. PMID: 35961152Free PMC Article
Johnson M, Åsberg Johnels J, Östlund S, Cedergren K, Omanovic Z, Hjalmarsson K, Jakobsson K, Högstedt J, Billstedt E
J Psychiatr Res 2021 Oct;142:204-209. Epub 2021 Aug 2 doi: 10.1016/j.jpsychires.2021.07.055. PMID: 34375772
Fernandez E, Johnson SL
Clin Psychol Rev 2016 Jun;46:124-35. Epub 2016 Apr 27 doi: 10.1016/j.cpr.2016.04.012. PMID: 27188635
Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N
J Am Acad Child Adolesc Psychiatry 1997 Jul;36(7):980-8. doi: 10.1097/00004583-199707000-00021. PMID: 9204677

Recent systematic reviews

Pouchon A, Nasserdine R, Dondé C, Bertrand A, Polosan M, Bioulac S
Expert Opin Pharmacother 2023 Sep-Dec;24(13):1497-1509. Epub 2023 Jun 21 doi: 10.1080/14656566.2023.2224920. PMID: 37300473
Fahrendorff AM, Pagsberg AK, Kessing LV, Maigaard K
Acta Psychiatr Scand 2023 Aug;148(2):110-132. Epub 2023 Mar 28 doi: 10.1111/acps.13548. PMID: 36941106
Lin X, He T, Heath M, Chi P, Hinshaw S
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710866. PMID: 36078582Free PMC Article
Pringsheim T, Hirsch L, Gardner D, Gorman DA
Can J Psychiatry 2015 Feb;60(2):42-51. doi: 10.1177/070674371506000202. PMID: 25886655Free PMC Article
Zwi M, Jones H, Thorgaard C, York A, Dennis JA
Cochrane Database Syst Rev 2011 Dec 7;2011(12):CD003018. doi: 10.1002/14651858.CD003018.pub3. PMID: 22161373Free PMC Article

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