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Orbit neoplasm

MedGen UID:
18190
•Concept ID:
C0029185
•
Neoplastic Process
Synonyms: Neoplasm, Orbital; Neoplasms, Orbital; Orbital Neoplasm; Orbital Neoplasms
SNOMED CT: Neoplasm of orbit proper (127003006); Neoplasm of orbit (127003006); Tumor of orbit (127003006)
 
Monarch Initiative: MONDO:0024611

Definition

A benign or malignant neoplasm that affects the orbit. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group.
Yahalom J, Illidge T, Specht L, Hoppe RT, Li YX, Tsang R, Wirth A; International Lymphoma Radiation Oncology Group
Int J Radiat Oncol Biol Phys 2015 May 1;92(1):11-31. doi: 10.1016/j.ijrobp.2015.01.009. PMID: 25863750

Recent clinical studies

Etiology

Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Orbital peripheral nerve sheath tumors.
Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang SH, Hanna E
Surv Ophthalmol 2017 Jan-Feb;62(1):43-57. Epub 2016 Aug 26 doi: 10.1016/j.survophthal.2016.08.002. PMID: 27570221
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Orbital carcinoid metastases.
Mehta JS, Abou-Rayyah Y, Rose GE
Ophthalmology 2006 Mar;113(3):466-72. Epub 2006 Feb 3 doi: 10.1016/j.ophtha.2005.10.051. PMID: 16458966

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Orbital Tumors and Inflammatory Disorders: Diagnosis and Management.
Neems L, Echalier EL, Subramanian PS
Int Ophthalmol Clin 2018 Spring;58(2):181-195. doi: 10.1097/IIO.0000000000000217. PMID: 29517650
Lymphoproliferative Disease of the Orbit.
Li EY, Yuen HK, Cheuk W
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):106-11. doi: 10.1097/APO.0000000000000102. PMID: 26065355
Cancer of the orbit and adnexa.
Schwarcz RM, Coupland SE, Finger PT
Am J Clin Oncol 2013 Apr;36(2):197-205. doi: 10.1097/COC.0b013e31820dbf28. PMID: 22157212

Therapy

PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.
Shome D, Esmaeli B
Curr Opin Ophthalmol 2008 Sep;19(5):414-21. doi: 10.1097/ICU.0b013e32830b1539. PMID: 18772675
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506
Periorbital hemangiomas.
Goldberg NS, Rosanova MA
Dermatol Clin 1992 Oct;10(4):653-61. PMID: 1395149

Prognosis

Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations.
Mombaerts I, Ramberg I, Coupland SE, Heegaard S
Surv Ophthalmol 2019 Nov-Dec;64(6):741-756. Epub 2019 Jul 2 doi: 10.1016/j.survophthal.2019.06.006. PMID: 31276737
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Life expectancy following orbital exenteration.
Wong JC, Thampy R, Cook A
Br J Ophthalmol 2015 Jan;99(1):1-4. Epub 2014 May 30 doi: 10.1136/bjophthalmol-2013-304436. PMID: 24879806
Metastatic orbital tumors.
Günalp I, Gündüz K
Jpn J Ophthalmol 1995;39(1):65-70. PMID: 7643486

Clinical prediction guides

Clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma.
Yang Y, Jin X, Wang Y, Ma R, He W
Clin Exp Ophthalmol 2023 Mar;51(2):154-161. Epub 2022 Nov 18 doi: 10.1111/ceo.14189. PMID: 36326836
Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations.
Mombaerts I, Ramberg I, Coupland SE, Heegaard S
Surv Ophthalmol 2019 Nov-Dec;64(6):741-756. Epub 2019 Jul 2 doi: 10.1016/j.survophthal.2019.06.006. PMID: 31276737
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Total lateral orbitotomy.
Kim JW, Yates BS, Goldberg RA
Orbit 2009;28(6):320-7. doi: 10.3109/01676830903334028. PMID: 19929652
Orbital venous anomalies.
Wright JE, Sullivan TJ, Garner A, Wulc AE, Moseley IF
Ophthalmology 1997 Jun;104(6):905-13. doi: 10.1016/s0161-6420(97)30208-5. PMID: 9186428

Recent systematic reviews

Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140

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