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Orchitis

MedGen UID:
18191
Concept ID:
C0029191
Disease or Syndrome
Synonym: Orchitides
SNOMED CT: Inflammation of testis (274718005); Orchitis (274718005); Non-specific orchitis (274718005)
 
HPO: HP:0100796
Monarch Initiative: MONDO:0006882

Definition

Testicular inflammation. [from HPO]

Conditions with this feature

Familial Mediterranean fever
MedGen UID:
45811
Concept ID:
C0031069
Disease or Syndrome
Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to renal failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.

Professional guidelines

PubMed

Gupta A, Khosa J, Barker A, Samnakay N
J Pediatr Surg 2022 Nov;57(11):690-695. Epub 2022 Jan 19 doi: 10.1016/j.jpedsurg.2022.01.013. PMID: 35101262
Epelboin S, Dulioust E, Epelboin L, Benachi A, Merlet F, Patrat C
Hum Reprod Update 2017 Nov 1;23(6):629-645. doi: 10.1093/humupd/dmx024. PMID: 28961800
Gkentzis A, Lee L
Ann R Coll Surg Engl 2014 Apr;96(3):181-3. doi: 10.1308/003588414X13814021679311. PMID: 24780779Free PMC Article

Recent clinical studies

Etiology

Xia P, Ouyang S, Shen R, Guo Z, Zhang G, Liu X, Yang X, Xie K, Wang D
Int J Mol Sci 2023 May 16;24(10) doi: 10.3390/ijms24108819. PMID: 37240164Free PMC Article
Wu H, Wang F, Tang D, Han D
Front Immunol 2021;12:582946. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.582946. PMID: 33815357Free PMC Article
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Bowlin PR, Gatti JM, Murphy JP
Surg Clin North Am 2017 Feb;97(1):161-172. doi: 10.1016/j.suc.2016.08.012. PMID: 27894425
Masarani M, Wazait H, Dinneen M
J R Soc Med 2006 Nov;99(11):573-5. doi: 10.1177/014107680609901116. PMID: 17082302Free PMC Article

Diagnosis

Siraj QH
Semin Nucl Med 2023 Nov;53(6):797-808. Epub 2023 May 18 doi: 10.1053/j.semnuclmed.2023.04.005. PMID: 37210316
Jin M, Fan Z, Gao R, Li X, Gao Z, Wang Z
Front Cell Infect Microbiol 2023;13:1136674. Epub 2023 Mar 31 doi: 10.3389/fcimb.2023.1136674. PMID: 37065189Free PMC Article
Silva CA, Cocuzza M, Carvalho JF, Bonfá E
Autoimmun Rev 2014 Apr-May;13(4-5):431-4. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.024. PMID: 24424181
Roy S, Hooda S, Parwani AV
Pathol Res Pract 2011 May 15;207(5):275-8. Epub 2011 Apr 1 doi: 10.1016/j.prp.2011.02.005. PMID: 21458170
Junnila J, Lassen P
Am Fam Physician 1998 Feb 15;57(4):685-92. PMID: 9490992

Therapy

Wu H, Wang F, Tang D, Han D
Front Immunol 2021;12:582946. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.582946. PMID: 33815357Free PMC Article
Reamy BV, Servey JT, Williams PM
Am Fam Physician 2020 Aug 15;102(4):229-233. PMID: 32803924
Taheri S, Zaghloul H, Chagoury O, Elhadad S, Ahmed SH, El Khatib N, Amona RA, El Nahas K, Suleiman N, Alnaama A, Al-Hamaq A, Charlson M, Wells MT, Al-Abdulla S, Abou-Samra AB
Lancet Diabetes Endocrinol 2020 Jun;8(6):477-489. doi: 10.1016/S2213-8587(20)30117-0. PMID: 32445735
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP
J Pathol 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. PMID: 25229387Free PMC Article

Prognosis

Jin M, Fan Z, Gao R, Li X, Gao Z, Wang Z
Front Cell Infect Microbiol 2023;13:1136674. Epub 2023 Mar 31 doi: 10.3389/fcimb.2023.1136674. PMID: 37065189Free PMC Article
Balawender K, Pliszka A, Krowiak A, Sito M, Grabarek BO, Boroń D
Curr Pharm Biotechnol 2022;23(15):1792-1799. doi: 10.2174/1389201023666220307102147. PMID: 35255789
Reamy BV, Servey JT, Williams PM
Am Fam Physician 2020 Aug 15;102(4):229-233. PMID: 32803924
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP
J Pathol 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. PMID: 25229387Free PMC Article

Clinical prediction guides

Xia P, Ouyang S, Shen R, Guo Z, Zhang G, Liu X, Yang X, Xie K, Wang D
Int J Mol Sci 2023 May 16;24(10) doi: 10.3390/ijms24108819. PMID: 37240164Free PMC Article
Zhang D, Li Y, Du C, Sang L, Liu L, Li Y, Wang F, Fan W, Tang P, Zhang S, Chen D, Wang Y, Wang X, Xie X, Jiang Z, Song Y, Guo R
J Transl Med 2022 Aug 12;20(1):363. doi: 10.1186/s12967-022-03566-6. PMID: 35962439Free PMC Article
Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP
J Pathol 2015 Jan;235(2):242-52. doi: 10.1002/path.4445. PMID: 25229387Free PMC Article
Silva CA, Cocuzza M, Borba EF, Bonfá E
Clin Rev Allergy Immunol 2012 Apr;42(2):256-63. doi: 10.1007/s12016-011-8281-z. PMID: 21842235
Jacobo P, Guazzone VA, Theas MS, Lustig L
Autoimmun Rev 2011 Feb;10(4):201-4. Epub 2010 Oct 14 doi: 10.1016/j.autrev.2010.09.026. PMID: 20932942

Recent systematic reviews

Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Schuppe HC, Pilatz A, Hossain H, Diemer T, Wagenlehner F, Weidner W
Dtsch Arztebl Int 2017 May 12;114(19):339-346. doi: 10.3238/arztebl.2017.0339. PMID: 28597829Free PMC Article
Gulino G, Antonucci M, Palermo G, Sasso F, Tienforti D, D'Addessi A, Bassi PF
Arch Ital Urol Androl 2012 Sep;84(3):105-10. PMID: 23210400
Elliman D, Sengupta N, El Bashir H, Bedford H
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454052
Schwingl PJ, Guess HA
Fertil Steril 2000 May;73(5):923-36. doi: 10.1016/s0015-0282(00)00482-9. PMID: 10785217

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