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Secondary hypertrophic osteoarthropathy

MedGen UID:: 18211
•Concept ID:: C0029412
•: Disease or Syndrome

Synonyms:	Disease, Marie-Bamberger; Hypertrophic Osteoarthropathies, Secondary; Hypertrophic Osteoarthropathy, Secondary; Marie Bamberger Disease; Marie-Bamberger Disease; Osteoarthropathies, Secondary Hypertrophic; Osteoarthropathy, Secondary Hypertrophic; Secondary Hypertrophic Osteoarthropathies; Secondary Hypertrophic Osteoarthropathy
SNOMED CT:	Hypertrophic pulmonary osteoarthropathy (203357004); Pachydermoperiostitis acquired (203357004); Marie Bamberger disease (203357004); HPOA - Hypertrophic pulmonary osteoarthropathy (203357004)

Monarch Initiative:	MONDO:0006965

Definition

Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed) [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSecondary hypertrophic osteoarthropathy

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Abnormal joint morphology
        Arthropathy
        Secondary hypertrophic osteoarthropathy

Professional guidelines

PubMed

Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management.

Nahar I, Al-Shemmeri M, Hussain M
Gulf J Oncolog 2007 Jan;1(1):71-6. PMID: 20084716

See all (1)

Recent clinical studies

Etiology

Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.

Essouma M, Nkeck JR, Agbor VN, Noubiap JJ
J Clin Rheumatol 2022 Mar 1;28(2):104-110. doi: 10.1097/RHU.0000000000001830. PMID: 35067513

Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors.

Meyer HJ, Leifels L, Bach AG, Surov A
Medicine (Baltimore) 2017 Sep;96(36):e7985. doi: 10.1097/MD.0000000000007985. PMID: 28885355 Free PMC Article

Cutaneous manifestations of lung cancer.

Owen CE
Semin Oncol 2016 Jun;43(3):366-9. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.025. PMID: 27178690

Extrathyroidal manifestations of Graves' disease: a 2014 update.

Bartalena L, Fatourechi V
J Endocrinol Invest 2014 Aug;37(8):691-700. Epub 2014 Jun 10 doi: 10.1007/s40618-014-0097-2. PMID: 24913238

Graphite pneumoconiosis.

Ranasinha KW, Uragoda CG
Br J Ind Med 1972 Apr;29(2):178-83. doi: 10.1136/oem.29.2.178. PMID: 5021997 Free PMC Article

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Diagnosis

Secondary Hypertrophic Osteoarthropathy.

Lucas Rocha M, Silvestre-Teixeira V
N Engl J Med 2024 Apr 4;390(13):1218. doi: 10.1056/NEJMicm2309119. PMID: 38598576

Hypertrophic osteoarthropathy.

Martínez-Lavín M
Best Pract Res Clin Rheumatol 2020 Jun;34(3):101507. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101507. PMID: 32291203

Touraine-Solente-Gole syndrome.

Doshi D
Orbit 2018 Apr;37(2):97-101. Epub 2017 Oct 17 doi: 10.1080/01676830.2017.1383459. PMID: 29040027

Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance.

Callemeyn J, Van Haecke P, Peetermans WE, Blockmans D
Acta Clin Belg 2016 Jun;71(3):123-30. Epub 2016 Apr 22 doi: 10.1080/17843286.2016.1152672. PMID: 27104368

Hypertrophic Osteoarthropathy.

Carlson S, Rauchenstein J
J Am Osteopath Assoc 2015 Dec;115(12):745. doi: 10.7556/jaoa.2015.153. PMID: 26618821

See all (446)

Therapy

Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.

Essouma M, Nkeck JR, Agbor VN, Noubiap JJ
J Clin Rheumatol 2022 Mar 1;28(2):104-110. doi: 10.1097/RHU.0000000000001830. PMID: 35067513

Primary hypertrophic osteoarthropathy: an update.

Zhang Z, Zhang C, Zhang Z
Front Med 2013 Mar;7(1):60-4. Epub 2013 Jan 23 doi: 10.1007/s11684-013-0246-6. PMID: 23345113

Touraine-Solente-Gole' syndrome.

Gupta M, Lehl SS, Singh R, Sachdev A
BMJ Case Rep 2011 Sep 28;2011 doi: 10.1136/bcr.08.2011.4605. PMID: 22679327 Free PMC Article

Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy.

Nguyen S, Hojjati M
Clin Rheumatol 2011 Jan;30(1):7-13. Epub 2010 Oct 9 doi: 10.1007/s10067-010-1563-7. PMID: 20936419

Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation.

Martinez-Lavin M, Vargas A, Rivera-Viñas M
Curr Opin Rheumatol 2008 Jan;20(1):88-91. doi: 10.1097/BOR.0b013e3282f14a5a. PMID: 18281863

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Prognosis

Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.

Bozzao F, Bernardi S, Dore F, Zandonà L, Fischetti F
BMC Musculoskelet Disord 2018 May 14;19(1):145. doi: 10.1186/s12891-018-2068-9. PMID: 29759083 Free PMC Article

Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance.

Callemeyn J, Van Haecke P, Peetermans WE, Blockmans D
Acta Clin Belg 2016 Jun;71(3):123-30. Epub 2016 Apr 22 doi: 10.1080/17843286.2016.1152672. PMID: 27104368

Hypertrophic osteoarthropathy secondary to vascular prosthesis infection: report of 3 cases and review of the literature.

Medicine (Baltimore) 2006 May;85(3):191. doi: 10.1097/01.md.0000224714.27508.8b. PMID: 16721260

Epithelioid haemangioendothelioma.

Ledson MJ, Convery R, Carty A, Evans CC
Thorax 1999 Jun;54(6):560-1. doi: 10.1136/thx.54.6.560. PMID: 10335015 Free PMC Article

Hypertrophic osteoarthropathy and intrathoracic Hodgkin disease of childhood.

Kebudi R, Ayan I, Erseven G, Görgün O, Darendeliler E, Celik A
Med Pediatr Oncol 1997 Dec;29(6):578-81. doi: 10.1002/(sici)1096-911x(199712)29:6<578::aid-mpo12>3.0.co;2-2. PMID: 9324349

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Clinical prediction guides

Massive periostosis in a child from Neolithic Gebel es-Silsileh, Egypt.

Gresky J, Schultz M
Anthropol Anz 2023 Sep 28;80(4):501-516. doi: 10.1127/anthranz/2022/1613. PMID: 36278913

Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany.

Flohr S, Jasch I, Langer A, Riesenberg M, Hahn J, Wisotzki A, Kierdorf H, Kierdorf U, Wahl J
Int J Paleopathol 2018 Mar;20:72-79. Epub 2017 Nov 21 doi: 10.1016/j.ijpp.2017.10.013. PMID: 29496219

Pseudoclubbing: is it different from clubbing?

Santiago MB, Lima I, Feitosa AC, Braz Ade S, Miranda LG
Semin Arthritis Rheum 2009 Jun;38(6):452-7. Epub 2008 Apr 18 doi: 10.1016/j.semarthrit.2008.01.018. PMID: 18378280

Diagnostic imaging in hypertrophic osteoarthropathy.

Pineda C
Clin Exp Rheumatol 1992 May-Jun;10 Suppl 7:27-33. PMID: 1623669

Diagnosis and treatment of cystic fibrosis. An update.

Davis PB, di Sant'Agnese PA
Chest 1984 Jun;85(6):802-9. doi: 10.1016/s0012-3692(16)62421-2. PMID: 6373170

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