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Metastatic Breast Carcinoma in the Skin

MedGen UID:
182595
•Concept ID:
C0935909
•
Neoplastic Process
Synonyms: Breast Carcinoma Metastatic in the Skin; Breast Carcinoma Metastatic to the Skin; Cutaneous Breast Cancer

Definition

A carcinoma that arises from the breast and has metastasized to the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Breast Carcinoma in the Skin

Professional guidelines

PubMed

Radiomics Improves Cancer Screening and Early Detection.
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666
Piceatannol: A natural stilbene for the prevention and treatment of cancer.
Banik K, Ranaware AM, Harsha C, Nitesh T, Girisa S, Deshpande V, Fan L, Nalawade SP, Sethi G, Kunnumakkara AB
Pharmacol Res 2020 Mar;153:104635. Epub 2020 Jan 8 doi: 10.1016/j.phrs.2020.104635. PMID: 31926274
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

Recent clinical studies

Etiology

Metastatic nonhematopoietic neoplasms to the breast: a study of 238 cases.
Zhou P, Chang N, Abraham SC, Albarracin CT, Huo L, Chen H, Ding Q, Resetkova E, Middleton LP, Sahin AA, Bu H, Wu Y
Hum Pathol 2022 Jul;125:59-67. Epub 2022 Apr 18 doi: 10.1016/j.humpath.2022.04.009. PMID: 35447141
Locoregional recurrence in skin-sparing and nipple-sparing mastectomies.
Costeira B, da Silva FB, Oom R, Costa C, Moniz JV, Abecasis N, Santos CR
J Surg Oncol 2022 Mar;125(3):352-360. Epub 2021 Oct 23 doi: 10.1002/jso.26725. PMID: 34687468
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review.
Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, Zhu Y, Tian Y
Radiat Oncol 2020 Jan 17;15(1):17. doi: 10.1186/s13014-020-1463-1. PMID: 31952507Free PMC Article
Cutaneous manifestations of breast cancer.
Tan AR
Semin Oncol 2016 Jun;43(3):331-4. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.030. PMID: 27178684
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article

Diagnosis

Locoregional recurrence in skin-sparing and nipple-sparing mastectomies.
Costeira B, da Silva FB, Oom R, Costa C, Moniz JV, Abecasis N, Santos CR
J Surg Oncol 2022 Mar;125(3):352-360. Epub 2021 Oct 23 doi: 10.1002/jso.26725. PMID: 34687468
Cutaneous metastases: A great imitator.
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Cutaneous Metastasis of Internal Tumors.
Choate EA, Nobori A, Worswick S
Dermatol Clin 2019 Oct;37(4):545-554. Epub 2019 Jul 10 doi: 10.1016/j.det.2019.05.012. PMID: 31466594
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Erysipelatoid Carcinoma.
Miguel TS, Costa DAD, Almeida APM, Pino LCM, Goldemberg DC, Miguel BS, Coelho Filho SCH
Rev Assoc Med Bras (1992) 2018 Jun;64(6):492-497. doi: 10.1590/1806-9282.64.06.492. PMID: 30304305

Therapy

Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review.
Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, Zhu Y, Tian Y
Radiat Oncol 2020 Jan 17;15(1):17. doi: 10.1186/s13014-020-1463-1. PMID: 31952507Free PMC Article
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article
Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY
J Clin Oncol 2008 Nov 10;26(32):5269-74. Epub 2008 Sep 22 doi: 10.1200/JCO.2008.17.3146. PMID: 18809609

Prognosis

Cutaneous metastases: A great imitator.
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review.
Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, Zhu Y, Tian Y
Radiat Oncol 2020 Jan 17;15(1):17. doi: 10.1186/s13014-020-1463-1. PMID: 31952507Free PMC Article
Unusual cutaneous metastatic carcinoma.
Ruiz SJ, Al Salihi S, Prieto VG, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Torres-Cabala CA, Aung PP
Ann Diagn Pathol 2019 Dec;43:151399. Epub 2019 Aug 12 doi: 10.1016/j.anndiagpath.2019.08.003. PMID: 31675677
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article

Clinical prediction guides

Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Locoregional recurrence in skin-sparing and nipple-sparing mastectomies.
Costeira B, da Silva FB, Oom R, Costa C, Moniz JV, Abecasis N, Santos CR
J Surg Oncol 2022 Mar;125(3):352-360. Epub 2021 Oct 23 doi: 10.1002/jso.26725. PMID: 34687468
Merkel cell carcinoma, melanoma, metastatic mimics of breast cancer.
Troxell ML
Semin Diagn Pathol 2017 Sep;34(5):479-495. Epub 2017 May 31 doi: 10.1053/j.semdp.2017.05.009. PMID: 28645508
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Roles of E- and P-cadherin in the human skin.
Furukawa F, Fujii K, Horiguchi Y, Matsuyoshi N, Fujita M, Toda K, Imamura S, Wakita H, Shirahama S, Takigawa M
Microsc Res Tech 1997 Aug 15;38(4):343-52. doi: 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K. PMID: 9297684

Recent systematic reviews

Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Green tea (Camellia sinensis) for the prevention of cancer.
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M
Cochrane Database Syst Rev 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3. PMID: 32118296Free PMC Article
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review.
Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, Zhu Y, Tian Y
Radiat Oncol 2020 Jan 17;15(1):17. doi: 10.1186/s13014-020-1463-1. PMID: 31952507Free PMC Article
Systemic antibiotics for treating malignant wounds.
Ramasubbu DA, Smith V, Hayden F, Cronin P
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD011609. doi: 10.1002/14651858.CD011609.pub2. PMID: 28837757Free PMC Article
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

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