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Metastatic Breast Carcinoma in the Skin

MedGen UID:
182595
•Concept ID:
C0935909
•
Neoplastic Process
Synonyms: Breast Carcinoma Metastatic in the Skin; Breast Carcinoma Metastatic to the Skin; Cutaneous Breast Cancer

Definition

A carcinoma that arises from the breast and has metastasized to the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Breast Carcinoma in the Skin

Professional guidelines

PubMed

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature.
Freeman T, Russell AJ, Council ML
Dermatol Surg 2023 Dec 1;49(12):1091-1095. Epub 2023 Aug 29 doi: 10.1097/DSS.0000000000003921. PMID: 37643246
Radiomics Improves Cancer Screening and Early Detection.
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

Recent clinical studies

Etiology

Skin-sparing mastectomy for the treatment of breast cancer.
Mota BS, Bevilacqua JLB, Barrett J, Ricci MD, Munhoz AM, Filassi JR, Baracat EC, Riera R
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD010993. doi: 10.1002/14651858.CD010993.pub2. PMID: 36972145Free PMC Article
Metastatic nonhematopoietic neoplasms to the breast: a study of 238 cases.
Zhou P, Chang N, Abraham SC, Albarracin CT, Huo L, Chen H, Ding Q, Resetkova E, Middleton LP, Sahin AA, Bu H, Wu Y
Hum Pathol 2022 Jul;125:59-67. Epub 2022 Apr 18 doi: 10.1016/j.humpath.2022.04.009. PMID: 35447141
Locoregional recurrence in skin-sparing and nipple-sparing mastectomies.
Costeira B, da Silva FB, Oom R, Costa C, Moniz JV, Abecasis N, Santos CR
J Surg Oncol 2022 Mar;125(3):352-360. Epub 2021 Oct 23 doi: 10.1002/jso.26725. PMID: 34687468
Cutaneous manifestations of breast cancer.
Tan AR
Semin Oncol 2016 Jun;43(3):331-4. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.030. PMID: 27178684
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article

Diagnosis

Cutaneous metastases: A great imitator.
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Cutaneous Metastasis of Internal Tumors.
Choate EA, Nobori A, Worswick S
Dermatol Clin 2019 Oct;37(4):545-554. Epub 2019 Jul 10 doi: 10.1016/j.det.2019.05.012. PMID: 31466594
Erysipelatoid Carcinoma.
Miguel TS, Costa DAD, Almeida APM, Pino LCM, Goldemberg DC, Miguel BS, Coelho Filho SCH
Rev Assoc Med Bras (1992) 2018 Jun;64(6):492-497. doi: 10.1590/1806-9282.64.06.492. PMID: 30304305
Cutaneous manifestations of breast cancer.
Tan AR
Semin Oncol 2016 Jun;43(3):331-4. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.030. PMID: 27178684
Sclerosing postirradiation panniculitis.
Requena L, Ferrándiz C
Dermatol Clin 2008 Oct;26(4):505-8, vii-viii. doi: 10.1016/j.det.2008.05.012. PMID: 18793984

Therapy

Dermatologic toxicities to inhibitors of cyclin-dependent kinases CDK 4 and 6: An updated review for clinical practice.
Sibaud V, Sollena P
Ann Dermatol Venereol 2023 Sep;150(3):208-212. Epub 2023 Aug 14 doi: 10.1016/j.annder.2022.11.013. PMID: 37586898
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article
Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY
J Clin Oncol 2008 Nov 10;26(32):5269-74. Epub 2008 Sep 22 doi: 10.1200/JCO.2008.17.3146. PMID: 18809609

Prognosis

Dermatologic toxicities to inhibitors of cyclin-dependent kinases CDK 4 and 6: An updated review for clinical practice.
Sibaud V, Sollena P
Ann Dermatol Venereol 2023 Sep;150(3):208-212. Epub 2023 Aug 14 doi: 10.1016/j.annder.2022.11.013. PMID: 37586898
Neoadjuvant chemotherapy in non-metastatic breast cancer: The surgeon's perspective.
Ofri A, Elstner K, Mann GB, Kumar S, Warrier S
Surgeon 2023 Dec;21(6):356-360. Epub 2023 Apr 21 doi: 10.1016/j.surge.2023.04.001. PMID: 37088639
Cutaneous metastases: A great imitator.
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Unusual cutaneous metastatic carcinoma.
Ruiz SJ, Al Salihi S, Prieto VG, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Torres-Cabala CA, Aung PP
Ann Diagn Pathol 2019 Dec;43:151399. Epub 2019 Aug 12 doi: 10.1016/j.anndiagpath.2019.08.003. PMID: 31675677
Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema.
Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H
BMC Cancer 2011 Mar 9;11:94. doi: 10.1186/1471-2407-11-94. PMID: 21392372Free PMC Article

Clinical prediction guides

Dermatologic toxicities to inhibitors of cyclin-dependent kinases CDK 4 and 6: An updated review for clinical practice.
Sibaud V, Sollena P
Ann Dermatol Venereol 2023 Sep;150(3):208-212. Epub 2023 Aug 14 doi: 10.1016/j.annder.2022.11.013. PMID: 37586898
Skin-sparing mastectomy for the treatment of breast cancer.
Mota BS, Bevilacqua JLB, Barrett J, Ricci MD, Munhoz AM, Filassi JR, Baracat EC, Riera R
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD010993. doi: 10.1002/14651858.CD010993.pub2. PMID: 36972145Free PMC Article
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial.
Behroozian T, Milton L, Karam I, Zhang L, Ding K, Lou J, Gallant F, Rakovitch E, Tran W, Soliman H, Leung E, Vesprini D, Szumacher E, Chen H, Donovan E, Lam J, Spadafora S, Wronski M, Lavoie C, Walde N, Lam E, Wong G, McKenzie E, Ariello K, Kennedy S, Shariati S, Carothers K, Gonzales G, Kagan Y, Chow E
J Clin Oncol 2023 Feb 20;41(6):1250-1264. Epub 2022 Dec 9 doi: 10.1200/JCO.22.01873. PMID: 36493331
Merkel cell carcinoma, melanoma, metastatic mimics of breast cancer.
Troxell ML
Semin Diagn Pathol 2017 Sep;34(5):479-495. Epub 2017 May 31 doi: 10.1053/j.semdp.2017.05.009. PMID: 28645508
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Sodium-glucose cotransporter 2 inhibitors and cancer: a systematic review and meta-analysis.
Xu B, Kang B, Li S, Fan S, Zhou J
J Endocrinol Invest 2024 Oct;47(10):2421-2436. Epub 2024 Mar 26 doi: 10.1007/s40618-024-02351-0. PMID: 38530620
Skin-sparing mastectomy for the treatment of breast cancer.
Mota BS, Bevilacqua JLB, Barrett J, Ricci MD, Munhoz AM, Filassi JR, Baracat EC, Riera R
Cochrane Database Syst Rev 2023 Mar 27;3(3):CD010993. doi: 10.1002/14651858.CD010993.pub2. PMID: 36972145Free PMC Article
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Green tea (Camellia sinensis) for the prevention of cancer.
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M
Cochrane Database Syst Rev 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3. PMID: 32118296Free PMC Article
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

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