U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mammary Paget disease

MedGen UID:
18263
Concept ID:
C0030185
Neoplastic Process
Synonyms: Paget disease of the breast; Paget's disease of the nipple; Paget's disease, mammary
SNOMED CT: Mammary Paget's disease (2985005); Paget disease, mammary (2985005); Paget's disease, mammary (2985005); Paget's disease of breast (2985005)
 
Monarch Initiative: MONDO:0002648

Definition

A malignant neoplasm in which there is infiltration of the skin overlying the breast by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It is almost always associated with an intraductal or invasive ductal carcinoma of the breast. The clinical features include focal skin reddening, and eczema. Retraction of the nipple may sometimes occur. [from NCI]

Professional guidelines

PubMed

Konstantinova AM, Spagnolo DV, Stewart CJR, Kacerovska D, Shelekhova KV, Plaza JA, Suster S, Bouda J, Kyrpychova L, Michal M, Belousova IE, Kerl K, Kazakov DV
Am J Surg Pathol 2017 Aug;41(8):1053-1058. doi: 10.1097/PAS.0000000000000857. PMID: 28614205

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Breast Cancer, 2023

Breast Cancer, NCCN Guidelines Version 4.2022

Recent clinical studies

Etiology

Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Tinca AC, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Chiorean DM, Morariu SH, Turdean SG, Cotoi OS
Rom J Morphol Embryol 2021 Jul-Sep;62(3):757-763. doi: 10.47162/RJME.62.3.13. PMID: 35263404Free PMC Article
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Loiacono RMR, Traversi P, Deliso MA, Gargano G, Kardhashi A, Francescato R, Loizzi V, Spinelli M, Lovascio S, Fiorito M, Resta L, Popescu O, Cicinelli E, Cormio G
Medicine (Baltimore) 2019 Oct;98(41):e17018. doi: 10.1097/MD.0000000000017018. PMID: 31593076Free PMC Article
Karpathiou G, Chauleur C, Hathroubi S, Habougit C, Peoc'h M
Cancer Immunol Immunother 2018 Aug;67(8):1297-1303. Epub 2018 Jun 25 doi: 10.1007/s00262-018-2189-x. PMID: 29943071Free PMC Article

Diagnosis

Cho WC, Ding Q, Wang WL, Nagarajan P, Curry JL, Torres-Cabala CA, Ivan D, Albarracin CT, Sahin A, Prieto VG, Aung PP
J Cutan Pathol 2023 May;50(5):434-440. Epub 2023 Mar 1 doi: 10.1111/cup.14414. PMID: 36808637
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Burke MJ, Middleton TO
J Am Osteopath Assoc 2013 Sep;113(9):712. doi: 10.7556/jaoa.2013.038. PMID: 24005092
Requena L, Sangueza M, Sangueza OP, Kutzner H
Am J Dermatopathol 2002 Jun;24(3):189-98. doi: 10.1097/00000372-200206000-00001. PMID: 12140433

Therapy

Bedard PL, Li S, Wisinski KB, Yang ES, Limaye SA, Mitchell EP, Zwiebel JA, Moscow JA, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
JCO Precis Oncol 2022 Jul;6:e2200165. doi: 10.1200/PO.22.00165. PMID: 35939768Free PMC Article
Torre-Castro J, Haya-Martínez L, Ruffin-Vicente B, Moya-Martínez C, Núñez-Hipólito L, Díaz de la Pinta J, Cullen-Aravena D, Jo-Velasco M, Requena L
J Cutan Pathol 2021 Jan;48(1):180-183. Epub 2020 Nov 10 doi: 10.1111/cup.13908. PMID: 33128407
Tonguc E, Güngor T, Var T, Ozat M, Sahin I, Sirvan L
Arch Gynecol Obstet 2011 Jan;283(1):97-101. Epub 2010 Aug 29 doi: 10.1007/s00404-010-1653-4. PMID: 20803209
Hatch KD, Davis JR
J Low Genit Tract Dis 2008 Apr;12(2):90-4. doi: 10.1097/LGT.0b013e31815a58a5. PMID: 18369301

Prognosis

Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Tinca AC, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Chiorean DM, Morariu SH, Turdean SG, Cotoi OS
Rom J Morphol Embryol 2021 Jul-Sep;62(3):757-763. doi: 10.47162/RJME.62.3.13. PMID: 35263404Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Fernandez-Flores A, Eraña I, Cuevas J
Am J Dermatopathol 2018 Oct;40(10):711-720. doi: 10.1097/DAD.0000000000001105. PMID: 30234560
Karpathiou G, Chauleur C, Hathroubi S, Habougit C, Peoc'h M
Cancer Immunol Immunother 2018 Aug;67(8):1297-1303. Epub 2018 Jun 25 doi: 10.1007/s00262-018-2189-x. PMID: 29943071Free PMC Article

Clinical prediction guides

Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Akishima-Fukasawa Y, Honma N, Ogata H, Akasaka Y, Mikami T
Diagn Pathol 2020 Jun 11;15(1):75. doi: 10.1186/s13000-020-00988-y. PMID: 32527320Free PMC Article
Loiacono RMR, Traversi P, Deliso MA, Gargano G, Kardhashi A, Francescato R, Loizzi V, Spinelli M, Lovascio S, Fiorito M, Resta L, Popescu O, Cicinelli E, Cormio G
Medicine (Baltimore) 2019 Oct;98(41):e17018. doi: 10.1097/MD.0000000000017018. PMID: 31593076Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904

Recent systematic reviews

Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Breast Cancer, 2023
    • NCCN, 2023
      Breast Cancer, NCCN Guidelines Version 4.2022

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...