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Reproductive System Hemorrhage

MedGen UID:
182679
•Concept ID:
C0947964
•
Pathologic Function
Synonym: Genital Bleeding

Definition

Bleeding originating in the organs and tissue that aid in reproduction. [from NCI]

Professional guidelines

PubMed

Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252
The Diagnosis and Treatment of Prostate Cancer: A Review.
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

Recent clinical studies

Etiology

Management of pre-, peri-, and post-menopausal abnormal uterine bleeding: When to perform endometrial sampling?
Papakonstantinou E, Adonakis G
Int J Gynaecol Obstet 2022 Aug;158(2):252-259. Epub 2021 Oct 31 doi: 10.1002/ijgo.13988. PMID: 34669187
Postpartum Hemorrhage.
Bienstock JL, Eke AC, Hueppchen NA
N Engl J Med 2021 Apr 29;384(17):1635-1645. doi: 10.1056/NEJMra1513247. PMID: 33913640Free PMC Article
Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement.
Muñoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, Goffinet F, Hofer S, Holzgreve W, Manrique S, Nizard J, Christory F, Samama CM, Hardy JF
Blood Transfus 2019 Mar;17(2):112-136. Epub 2019 Feb 6 doi: 10.2450/2019.0245-18. PMID: 30865585Free PMC Article
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252
Potential adverse effects of nanoparticles on the reproductive system.
Wang R, Song B, Wu J, Zhang Y, Chen A, Shao L
Int J Nanomedicine 2018;13:8487-8506. Epub 2018 Dec 11 doi: 10.2147/IJN.S170723. PMID: 30587973Free PMC Article

Diagnosis

Uterine bleeding: how understanding endometrial physiology underpins menstrual health.
Jain V, Chodankar RR, Maybin JA, Critchley HOD
Nat Rev Endocrinol 2022 May;18(5):290-308. Epub 2022 Feb 8 doi: 10.1038/s41574-021-00629-4. PMID: 35136207Free PMC Article
The development of the human uterus: morphogenesis to menarche.
Habiba M, Heyn R, Bianchi P, Brosens I, Benagiano G
Hum Reprod Update 2021 Jan 4;27(1):1-26. doi: 10.1093/humupd/dmaa036. PMID: 33395479
Ovarian ectopic pregnancy.
Szadok P, Kubiaczyk F, Bajorek A, Suchocki S
Ginekol Pol 2019;90(12):728. doi: 10.5603/GP.2019.0125. PMID: 31909468
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
First Trimester Bleeding: Evaluation and Management.
Hendriks E, MacNaughton H, MacKenzie MC
Am Fam Physician 2019 Feb 1;99(3):166-174. PMID: 30702252

Therapy

The effect of endocrine disruptors on the reproductive system - current knowledge.
Czarnywojtek A, Jaz K, Ochmańska A, Zgorzalewicz-Stachowiak M, Czarnocka B, Sawicka-Gutaj N, Ziółkowska P, Krela-Kaźmierczak I, Gut P, Florek E, Ruchała M
Eur Rev Med Pharmacol Sci 2021 Aug;25(15):4930-4940. doi: 10.26355/eurrev_202108_26450. PMID: 34355365
Potential adverse effects of nanoparticles on the reproductive system.
Wang R, Song B, Wu J, Zhang Y, Chen A, Shao L
Int J Nanomedicine 2018;13:8487-8506. Epub 2018 Dec 11 doi: 10.2147/IJN.S170723. PMID: 30587973Free PMC Article
Management of post-partum haemorrhage.
Ahonen J, Stefanovic V, Lassila R
Acta Anaesthesiol Scand 2010 Nov;54(10):1164-78. doi: 10.1111/j.1399-6576.2010.02309.x. PMID: 21069897
Postpartum hemorrhage.
Ramanathan G, Arulkumaran S
J Obstet Gynaecol Can 2006 Nov;28(11):967-973. doi: 10.1016/S1701-2163(16)32308-8. PMID: 17169221
Vasectomy.
Qureshi F
Aust Fam Physician 1984 Oct;13(10):734-5, 737. PMID: 6508643

Prognosis

Vaginal Bleeding Before 20 Weeks Gestation.
Banwarth-Kuhn B, McQuade M, Krashin JW
Obstet Gynecol Clin North Am 2023 Sep;50(3):473-492. Epub 2023 May 20 doi: 10.1016/j.ogc.2023.03.004. PMID: 37500211
Maternal and neonatal trauma following operative vaginal delivery.
Muraca GM, Boutin A, Razaz N, Lisonkova S, John S, Ting JY, Scott H, Kramer MS, Joseph KS
CMAJ 2022 Jan 10;194(1):E1-E12. doi: 10.1503/cmaj.210841. PMID: 35012946Free PMC Article
Obesity Is Strongly Associated With Low Testosterone and Reduced Penis Growth During Development.
Mancini M, Pecori Giraldi F, Andreassi A, Mantellassi G, Salvioni M, Berra CC, Manfrini R, Banderali G, Folli F
J Clin Endocrinol Metab 2021 Oct 21;106(11):3151-3159. doi: 10.1210/clinem/dgab535. PMID: 34283215
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Menorrhagia.
Duckitt K, Collins S
BMJ Clin Evid 2008 Sep 18;2008 PMID: 19445802Free PMC Article

Clinical prediction guides

Impact of waterbirth on post-partum hemorrhage, genital trauma, retained placenta and shoulder dystocia: A systematic review and meta-analysis.
Cristina T, Mara T, Arianna S, Gennaro S, Rosaria C, Pantaleo G
Eur J Obstet Gynecol Reprod Biol 2022 Sep;276:26-37. Epub 2022 Jun 23 doi: 10.1016/j.ejogrb.2022.06.016. PMID: 35797821
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
The development of the human uterus: morphogenesis to menarche.
Habiba M, Heyn R, Bianchi P, Brosens I, Benagiano G
Hum Reprod Update 2021 Jan 4;27(1):1-26. doi: 10.1093/humupd/dmaa036. PMID: 33395479
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding.
Schatz F, Guzeloglu-Kayisli O, Arlier S, Kayisli UA, Lockwood CJ
Hum Reprod Update 2016 Jun;22(4):497-515. Epub 2016 Feb 23 doi: 10.1093/humupd/dmw004. PMID: 26912000Free PMC Article

Recent systematic reviews

Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery.
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.
Global Burden of Disease 2019 Cancer Collaboration, Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Harvey JD, Henrikson HJ, Lu D, Pennini A, Xu R, Ababneh E, Abbasi-Kangevari M, Abbastabar H, Abd-Elsalam SM, Abdoli A, Abedi A, Abidi H, Abolhassani H, Adedeji IA, Adnani QES, Advani SM, Afzal MS, Aghaali M, Ahinkorah BO, Ahmad S, Ahmad T, Ahmadi A, Ahmadi S, Ahmed Rashid T, Ahmed Salih Y, Akalu GT, Aklilu A, Akram T, Akunna CJ, Al Hamad H, Alahdab F, Al-Aly Z, Ali S, Alimohamadi Y, Alipour V, Aljunid SM, Alkhayyat M, Almasi-Hashiani A, Almasri NA, Al-Maweri SAA, Almustanyir S, Alonso N, Alvis-Guzman N, Amu H, Anbesu EW, Ancuceanu R, Ansari F, Ansari-Moghaddam A, Antwi MH, Anvari D, Anyasodor AE, Aqeel M, Arabloo J, Arab-Zozani M, Aremu O, Ariffin H, Aripov T, Arshad M, Artaman A, Arulappan J, Asemi Z, Asghari Jafarabadi M, Ashraf T, Atorkey P, Aujayeb A, Ausloos M, Awedew AF, Ayala Quintanilla BP, Ayenew T, Azab MA, Azadnajafabad S, Azari Jafari A, Azarian G, Azzam AY, Badiye AD, Bahadory S, Baig AA, Baker JL, Balakrishnan S, Banach M, Bärnighausen TW, Barone-Adesi F, Barra F, Barrow A, Behzadifar M, Belgaumi UI, Bezabhe WMM, Bezabih YM, Bhagat DS, Bhagavathula AS, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhattacharyya K, Bhojaraja VS, Bibi S, Bijani A, Biondi A, Bisignano C, Bjørge T, Bleyer A, Blyuss O, Bolarinwa OA, Bolla SR, Braithwaite D, Brar A, Brenner H, Bustamante-Teixeira MT, Butt NS, Butt ZA, Caetano Dos Santos FL, Cao Y, Carreras G, Catalá-López F, Cembranel F, Cerin E, Cernigliaro A, Chakinala RC, Chattu SK, Chattu VK, Chaturvedi P, Chimed-Ochir O, Cho DY, Christopher DJ, Chu DT, Chung MT, Conde J, Cortés S, Cortesi PA, Costa VM, Cunha AR, Dadras O, Dagnew AB, Dahlawi SMA, Dai X, Dandona L, Dandona R, Darwesh AM, das Neves J, De la Hoz FP, Demis AB, Denova-Gutiérrez E, Dhamnetiya D, Dhimal ML, Dhimal M, Dianatinasab M, Diaz D, Djalalinia S, Do HP, Doaei S, Dorostkar F, Dos Santos Figueiredo FW, Driscoll TR, Ebrahimi H, Eftekharzadeh S, El Tantawi M, El-Abid H, Elbarazi I, Elhabashy HR, Elhadi M, El-Jaafary SI, Eshrati B, Eskandarieh S, Esmaeilzadeh F, Etemadi A, Ezzikouri S, Faisaluddin M, Faraon EJA, Fares J, Farzadfar F, Feroze AH, Ferrero S, Ferro Desideri L, Filip I, Fischer F, Fisher JL, Foroutan M, Fukumoto T, Gaal PA, Gad MM, Gadanya MA, Gallus S, Gaspar Fonseca M, Getachew Obsa A, Ghafourifard M, Ghashghaee A, Ghith N, Gholamalizadeh M, Gilani SA, Ginindza TG, Gizaw ATT, Glasbey JC, Golechha M, Goleij P, Gomez RS, Gopalani SV, Gorini G, Goudarzi H, Grosso G, Gubari MIM, Guerra MR, Guha A, Gunasekera DS, Gupta B, Gupta VB, Gupta VK, Gutiérrez RA, Hafezi-Nejad N, Haider MR, Haj-Mirzaian A, Halwani R, Hamadeh RR, Hameed S, Hamidi S, Hanif A, Haque S, Harlianto NI, Haro JM, Hasaballah AI, Hassanipour S, Hay RJ, Hay SI, Hayat K, Heidari G, Heidari M, Herrera-Serna BY, Herteliu C, Hezam K, Holla R, Hossain MM, Hossain MBH, Hosseini MS, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Huang J, Hugo FN, Hussain R, Hussein NR, Hwang BF, Iavicoli I, Ibitoye SE, Ida F, Ikuta KS, Ilesanmi OS, Ilic IM, Ilic MD, Irham LM, Islam JY, Islam RM, Islam SMS, Ismail NE, Isola G, Iwagami M, Jacob L, Jain V, Jakovljevic MB, Javaheri T, Jayaram S, Jazayeri SB, Jha RP, Jonas JB, Joo T, Joseph N, Joukar F, Jürisson M, Kabir A, Kahrizi D, Kalankesh LR, Kalhor R, Kaliyadan F, Kalkonde Y, Kamath A, Kameran Al-Salihi N, Kandel H, Kapoor N, Karch A, Kasa AS, Katikireddi SV, Kauppila JH, Kavetskyy T, Kebede SA, Keshavarz P, Keykhaei M, Khader YS, Khalilov R, Khan G, Khan M, Khan MN, Khan MAB, Khang YH, Khater AM, Khayamzadeh M, Kim GR, Kim YJ, Kisa A, Kisa S, Kissimova-Skarbek K, Kopec JA, Koteeswaran R, Koul PA, Koulmane Laxminarayana SL, Koyanagi A, Kucuk Bicer B, Kugbey N, Kumar GA, Kumar N, Kumar N, Kurmi OP, Kutluk T, La Vecchia C, Lami FH, Landires I, Lauriola P, Lee SW, Lee SWH, Lee WC, Lee YH, Leigh J, Leong E, Li J, Li MC, Liu X, Loureiro JA, Lunevicius R, Magdy Abd El Razek M, Majeed A, Makki A, Male S, Malik AA, Mansournia MA, Martini S, Masoumi SZ, Mathur P, McKee M, Mehrotra R, Mendoza W, Menezes RG, Mengesha EW, Mesregah MK, Mestrovic T, Miao Jonasson J, Miazgowski B, Miazgowski T, Michalek IM, Miller TR, Mirzaei H, Mirzaei HR, Misra S, Mithra P, Moghadaszadeh M, Mohammad KA, Mohammad Y, Mohammadi M, Mohammadi SM, Mohammadian-Hafshejani A, Mohammed S, Moka N, Mokdad AH, Molokhia M, Monasta L, Moni MA, Moosavi MA, Moradi Y, Moraga P, Morgado-da-Costa J, Morrison SD, Mosapour A, Mubarik S, Mwanri L, Nagarajan AJ, Nagaraju SP, Nagata C, Naimzada MD, Nangia V, Naqvi AA, Narasimha Swamy S, Ndejjo R, Nduaguba SO, Negoi I, Negru SM, Neupane Kandel S, Nguyen CT, Nguyen HLT, Niazi RK, Nnaji CA, Noor NM, Nuñez-Samudio V, Nzoputam CI, Oancea B, Ochir C, Odukoya OO, Ogbo FA, Olagunju AT, Olakunde BO, Omar E, Omar Bali A, Omonisi AEE, Ong S, Onwujekwe OE, Orru H, Ortega-Altamirano DV, Otstavnov N, Otstavnov SS, Owolabi MO, P A M, Padubidri JR, Pakshir K, Pana A, Panagiotakos D, Panda-Jonas S, Pardhan S, Park EC, Park EK, Pashazadeh Kan F, Patel HK, Patel JR, Pati S, Pattanshetty SM, Paudel U, Pereira DM, Pereira RB, Perianayagam A, Pillay JD, Pirouzpanah S, Pishgar F, Podder I, Postma MJ, Pourjafar H, Prashant A, Preotescu L, Rabiee M, Rabiee N, Radfar A, Radhakrishnan RA, Radhakrishnan V, Rafiee A, Rahim F, Rahimzadeh S, Rahman M, Rahman MA, Rahmani AM, Rajai N, Rajesh A, Rakovac I, Ram P, Ramezanzadeh K, Ranabhat K, Ranasinghe P, Rao CR, Rao SJ, Rawassizadeh R, Razeghinia MS, Renzaho AMN, Rezaei N, Rezaei N, Rezapour A, Roberts TJ, Rodriguez JAB, Rohloff P, Romoli M, Ronfani L, Roshandel G, Rwegerera GM, S M, Sabour S, Saddik B, Saeed U, Sahebkar A, Sahoo H, Salehi S, Salem MR, Salimzadeh H, Samaei M, Samy AM, Sanabria J, Sankararaman S, Santric-Milicevic MM, Sardiwalla Y, Sarveazad A, Sathian B, Sawhney M, Saylan M, Schneider IJC, Sekerija M, Seylani A, Shafaat O, Shaghaghi Z, Shaikh MA, Shamsoddin E, Shannawaz M, Sharma R, Sheikh A, Sheikhbahaei S, Shetty A, Shetty JK, Shetty PH, Shibuya K, Shirkoohi R, Shivakumar KM, Shivarov V, Siabani S, Siddappa Malleshappa SK, Silva DAS, Singh JA, Sintayehu Y, Skryabin VY, Skryabina AA, Soeberg MJ, Sofi-Mahmudi A, Sotoudeh H, Steiropoulos P, Straif K, Subedi R, Sufiyan MB, Sultan I, Sultana S, Sur D, Szerencsés V, Szócska M, Tabarés-Seisdedos R, Tabuchi T, Tadbiri H, Taherkhani A, Takahashi K, Talaat IM, Tan KK, Tat VY, Tedla BAA, Tefera YG, Tehrani-Banihashemi A, Temsah MH, Tesfay FH, Tessema GA, Thapar R, Thavamani A, Thoguluva Chandrasekar V, Thomas N, Tohidinik HR, Touvier M, Tovani-Palone MR, Traini E, Tran BX, Tran KB, Tran MTN, Tripathy JP, Tusa BS, Ullah I, Ullah S, Umapathi KK, Unnikrishnan B, Upadhyay E, Vacante M, Vaezi M, Valadan Tahbaz S, Velazquez DZ, Veroux M, Violante FS, Vlassov V, Vo B, Volovici V, Vu GT, Waheed Y, Wamai RG, Ward P, Wen YF, Westerman R, Winkler AS, Yadav L, Yahyazadeh Jabbari SH, Yang L, Yaya S, Yazie TSY, Yeshaw Y, Yonemoto N, Younis MZ, Yousefi Z, Yu C, Yuce D, Yunusa I, Zadnik V, Zare F, Zastrozhin MS, Zastrozhina A, Zhang J, Zhong C, Zhou L, Zhu C, Ziapour A, Zimmermann IR, Fitzmaurice C, Murray CJL, Force LM
JAMA Oncol 2022 Mar 1;8(3):420-444. doi: 10.1001/jamaoncol.2021.6987. PMID: 34967848Free PMC Article
Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new finding.
Mohsen A, Fatemeh K, Leila N, Mona P, Mohammad Z, Mozafar K
J Tradit Chin Med 2021 Aug;41(4):642-649. doi: 10.19852/j.cnki.jtcm.20210324.001. PMID: 34392659
Use of platelet-rich fibrin in regenerative dentistry: a systematic review.
Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, Fujioka-Kobayashi M, Bishara M, Zhang Y, Wang HL, Chandad F, Nacopoulos C, Simonpieri A, Aalam AA, Felice P, Sammartino G, Ghanaati S, Hernandez MA, Choukroun J
Clin Oral Investig 2017 Jul;21(6):1913-1927. Epub 2017 May 27 doi: 10.1007/s00784-017-2133-z. PMID: 28551729
Effects of Anabolic Androgenic Steroids on the Reproductive System of Athletes and Recreational Users: A Systematic Review and Meta-Analysis.
Christou MA, Christou PA, Markozannes G, Tsatsoulis A, Mastorakos G, Tigas S
Sports Med 2017 Sep;47(9):1869-1883. doi: 10.1007/s40279-017-0709-z. PMID: 28258581

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