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Paralytic ileus

MedGen UID:
18293
Concept ID:
C0030446
Disease or Syndrome
Synonym: Paralytic Ileus
SNOMED CT: Paralytic ileus (55525008); Adynamic ileus (55525008); Paralysis of intestine (55525008)
 
HPO: HP:0002590
Monarch Initiative: MONDO:0004568

Definition

An ileus caused by abdominal or pelvic surgery, infections, disorders that affect the muscles and nerves, and medications. Signs and symptoms include those of intestinal obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParalytic ileus

Conditions with this feature

Acute intermittent porphyria
MedGen UID:
56452
Concept ID:
C0162565
Disease or Syndrome
Acute intermittent porphyria (AIP), an autosomal dominant disorder, occurs in heterozygotes for an HMBS pathogenic variant that causes reduced activity of the enzyme porphobilinogen deaminase. AIP is considered "overt" in a heterozygote who was previously or is currently symptomatic; AIP is considered "latent" in a heterozygote who has never had symptoms, and typically has been identified during molecular genetic testing of at-risk family members. Note that GeneReviews does not use the term "carrier" for an individual who is heterozygous for an autosomal dominant pathogenic variant; GeneReviews reserves the term "carrier" for an individual who is heterozygous for an autosomal recessive disorder and thus is not expected to ever develop manifestations of the disorder. Overt AIP is characterized clinically by life-threatening acute neurovisceral attacks of severe abdominal pain without peritoneal signs, often accompanied by nausea, vomiting, tachycardia, and hypertension. Attacks may be complicated by neurologic findings (mental changes, convulsions, and peripheral neuropathy that may progress to respiratory paralysis), and hyponatremia. Acute attacks, which may be provoked by certain drugs, alcoholic beverages, endocrine factors, calorie restriction, stress, and infections, usually resolve within two weeks. Most individuals with AIP have one or a few attacks; about 3%-8% (mainly women) have recurrent attacks (defined as >3 attacks/year) that may persist for years. Other long-term complications are chronic renal failure, hepatocellular carcinoma (HCC), and hypertension. Attacks, which are very rare before puberty, are more common in women than men. Latent AIP. While all individuals heterozygous for an HMBS pathogenic variant that predisposes to AIP are at risk of developing overt AIP, most have latent AIP and never have symptoms.
Tyrosinemia type I
MedGen UID:
75688
Concept ID:
C0268490
Disease or Syndrome
Untreated tyrosinemia type I usually presents either in young infants with severe liver involvement or later in the first year with liver dysfunction and renal tubular dysfunction associated with growth failure and rickets. Untreated children may have repeated, often unrecognized, neurologic crises lasting one to seven days that can include change in mental status, abdominal pain, peripheral neuropathy, and/or respiratory failure requiring mechanical ventilation. Death in the untreated child usually occurs before age ten years, typically from liver failure, neurologic crisis, or hepatocellular carcinoma. Combined treatment with nitisinone and a low-tyrosine diet has resulted in a greater than 90% survival rate, normal growth, improved liver function, prevention of cirrhosis, correction of renal tubular acidosis, and improvement in secondary rickets.
Combined oxidative phosphorylation defect type 7
MedGen UID:
462151
Concept ID:
C3150801
Disease or Syndrome
A rare mitochondrial disease due to a defect in mitochondrial protein synthesis with a variable phenotype that includes onset in infancy or early childhood of failure to thrive and psychomotor regression (after initial normal development), as well as ocular manifestations (such as ptosis, nystagmus, optic atrophy, ophthalmoplegia and reduced vision). Additional manifestations include bulbar paresis with facial weakness, hypotonia, difficulty chewing, dysphagia, mild dysarthria, ataxia, global muscle atrophy, and areflexia. It has a relatively slow disease progression with patients often living into the third decade of life.

Professional guidelines

PubMed

Alkan S, Cakir M, Sentiurk M, Varman A, Duyan AG
Niger J Clin Pract 2023 Apr;26(4):497-501. doi: 10.4103/njcp.njcp_618_22. PMID: 37203116
Buonfrate D, Rodari P, Barda B, Page W, Einsiedel L, Watts MR
Expert Opin Pharmacother 2022 Oct;23(14):1617-1628. Epub 2022 Aug 24 doi: 10.1080/14656566.2022.2114829. PMID: 35983698
Zlakishvili B, Sela HY, Tankel J, Ioscovich A, Rotem R, Grisaru-Granovsky S, Rottenstreich M
Eur J Obstet Gynecol Reprod Biol 2022 Feb;269:55-61. Epub 2021 Dec 20 doi: 10.1016/j.ejogrb.2021.12.019. PMID: 34968875

Recent clinical studies

Etiology

Malik M, Magsi AM, Parveen S, Khan MI, Iqbal M
J Pak Med Assoc 2023 Jul;73(7):1506-1510. doi: 10.47391/JPMA.4768. PMID: 37469068
Zhang T, Sun Y, Mao W
Int J Colorectal Dis 2023 May 30;38(1):147. doi: 10.1007/s00384-023-04445-2. PMID: 37248431
Alkan S, Cakir M, Sentiurk M, Varman A, Duyan AG
Niger J Clin Pract 2023 Apr;26(4):497-501. doi: 10.4103/njcp.njcp_618_22. PMID: 37203116
Daniels AH, Ritterman SA, Rubin LE
J Am Acad Orthop Surg 2015 Jun;23(6):365-72. Epub 2015 Apr 26 doi: 10.5435/JAAOS-D-14-00162. PMID: 25917235
Carlson GL, Dark P
Curr Opin Crit Care 2010 Aug;16(4):347-52. doi: 10.1097/MCC.0b013e328339fabe. PMID: 20489609

Diagnosis

Alkan S, Cakir M, Sentiurk M, Varman A, Duyan AG
Niger J Clin Pract 2023 Apr;26(4):497-501. doi: 10.4103/njcp.njcp_618_22. PMID: 37203116
Lim TSH, Aw M, Slosky L, Nyp SS
J Dev Behav Pediatr 2020 Oct-Nov;41(8):656-658. doi: 10.1097/DBP.0000000000000846. PMID: 32826694
Daniels AH, Ritterman SA, Rubin LE
J Am Acad Orthop Surg 2015 Jun;23(6):365-72. Epub 2015 Apr 26 doi: 10.5435/JAAOS-D-14-00162. PMID: 25917235
Carlson TL, Plackett TP, Gagliano RA Jr, Smith RR
Hawaii J Med Public Health 2012 Feb;71(2):44-5. PMID: 22454809Free PMC Article
Carlson GL, Dark P
Curr Opin Crit Care 2010 Aug;16(4):347-52. doi: 10.1097/MCC.0b013e328339fabe. PMID: 20489609

Therapy

Zhang T, Sun Y, Mao W
Int J Colorectal Dis 2023 May 30;38(1):147. doi: 10.1007/s00384-023-04445-2. PMID: 37248431
Wattchow D, Heitmann P, Smolilo D, Spencer NJ, Parker D, Hibberd T, Brookes SSJ, Dinning PG, Costa M
Neurogastroenterol Motil 2021 May;33(5):e14046. Epub 2020 Nov 30 doi: 10.1111/nmo.14046. PMID: 33252179
Khan MW, Ghauri SK, Shamim S
J Coll Physicians Surg Pak 2016 Dec;26(12):989-991. PMID: 28043313
Daniels AH, Ritterman SA, Rubin LE
J Am Acad Orthop Surg 2015 Jun;23(6):365-72. Epub 2015 Apr 26 doi: 10.5435/JAAOS-D-14-00162. PMID: 25917235
Carlson TL, Plackett TP, Gagliano RA Jr, Smith RR
Hawaii J Med Public Health 2012 Feb;71(2):44-5. PMID: 22454809Free PMC Article

Prognosis

Mancilla Asencio C, Berger Fleiszig Z
Medicina (Kaunas) 2022 Jun 10;58(6) doi: 10.3390/medicina58060785. PMID: 35744049Free PMC Article
Zlakishvili B, Sela HY, Tankel J, Ioscovich A, Rotem R, Grisaru-Granovsky S, Rottenstreich M
Eur J Obstet Gynecol Reprod Biol 2022 Feb;269:55-61. Epub 2021 Dec 20 doi: 10.1016/j.ejogrb.2021.12.019. PMID: 34968875
Ward AE, Ahmed R, Adedeji JF, McGregor-Riley J
Injury 2022 Feb;53(2):546-550. Epub 2021 Oct 1 doi: 10.1016/j.injury.2021.09.040. PMID: 34696902
Wattchow D, Heitmann P, Smolilo D, Spencer NJ, Parker D, Hibberd T, Brookes SSJ, Dinning PG, Costa M
Neurogastroenterol Motil 2021 May;33(5):e14046. Epub 2020 Nov 30 doi: 10.1111/nmo.14046. PMID: 33252179
Ramirez JA, McIntosh AG, Strehlow R, Lawrence VA, Parekh DJ, Svatek RS
Eur Urol 2013 Oct;64(4):588-97. Epub 2012 Dec 5 doi: 10.1016/j.eururo.2012.11.051. PMID: 23245816

Clinical prediction guides

Malik M, Magsi AM, Parveen S, Khan MI, Iqbal M
J Pak Med Assoc 2023 Jul;73(7):1506-1510. doi: 10.47391/JPMA.4768. PMID: 37469068
Mancilla Asencio C, Berger Fleiszig Z
Medicina (Kaunas) 2022 Jun 10;58(6) doi: 10.3390/medicina58060785. PMID: 35744049Free PMC Article
Lim TSH, Aw M, Slosky L, Nyp SS
J Dev Behav Pediatr 2020 Oct-Nov;41(8):656-658. doi: 10.1097/DBP.0000000000000846. PMID: 32826694
Oh CH, Ji GY, Yoon SH, Hyun D, Park HC, Kim YJ
Yonsei Med J 2015 Nov;56(6):1627-31. doi: 10.3349/ymj.2015.56.6.1627. PMID: 26446646Free PMC Article
COLE WH
Calif Med 1950 Nov;73(5):384-90. PMID: 14778004Free PMC Article

Recent systematic reviews

Rouva G, Vergadi E, Galanakis E
Acta Paediatr 2022 Mar;111(3):467-472. Epub 2021 Dec 3 doi: 10.1111/apa.16178. PMID: 34751972
Castro PM, Akerman D, Munhoz CB, Sacramento Id, Mazzurana M, Alvarez GA
Arq Bras Cir Dig 2014 Apr-Jun;27(2):148-53. doi: 10.1590/s0102-67202014000200013. PMID: 25004295Free PMC Article
Twine CP, Humphreys AK, Williams IM
Eur J Vasc Endovasc Surg 2013 Jul;46(1):36-47. Epub 2013 Apr 13 doi: 10.1016/j.ejvs.2013.03.018. PMID: 23590870
Ramirez JA, McIntosh AG, Strehlow R, Lawrence VA, Parekh DJ, Svatek RS
Eur Urol 2013 Oct;64(4):588-97. Epub 2012 Dec 5 doi: 10.1016/j.eururo.2012.11.051. PMID: 23245816
Fitzgerald JE, Ahmed I
World J Surg 2009 Dec;33(12):2557-66. doi: 10.1007/s00268-009-0104-5. PMID: 19763686

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