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Virus-Related Malignant Neoplasm

MedGen UID:
183098
•Concept ID:
C0920673
•
Neoplastic Process
Synonyms: Virus Related Cancer; Virus Related Malignancy; Virus-Related Cancer; Virus-Related Malignancy

Definition

A malignancy in which there is a well-documented association between a neoplastic process and a specific virus as the causative agent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVirus-Related Malignant Neoplasm

Professional guidelines

PubMed

Dental Management of the Human Papilloma Virus-Related Oropharyngeal Cancer Patient.
Rigert J, Pinto A, Mupparapu M
Dent Clin North Am 2023 Jul;67(3):453-456. Epub 2023 Mar 25 doi: 10.1016/j.cden.2023.02.017. PMID: 37244713
Hepatitis C: clinical management and debated issues.
Gitto S, Cursaro C, Bartoli A, Margotti M, Andreone P
Minerva Med 2021 Apr;112(2):228-237. Epub 2020 Dec 15 doi: 10.23736/S0026-4806.20.07208-0. PMID: 33319975
Human papilloma virus-related oropharyngeal cancer: opportunities and challenges in dysphagia management.
Goldsmith TA, Roe JW
Curr Opin Otolaryngol Head Neck Surg 2015 Jun;23(3):185-90. doi: 10.1097/MOO.0000000000000154. PMID: 25943965

Recent clinical studies

Etiology

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Translational Regulation in Hepatocellular Carcinogenesis.
Bracic Tomazic S, Schatz C, Haybaeck J
Drug Des Devel Ther 2021;15:4359-4369. Epub 2021 Oct 14 doi: 10.2147/DDDT.S255582. PMID: 34703211Free PMC Article
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Diagnosis

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma.
Sun R, Li J, Lin X, Yang Y, Liu B, Lan T, Xiao S, Deng A, Yin Z, Xu Y, Xiang Z, Wu B
Front Immunol 2023;14:1079495. Epub 2023 Apr 3 doi: 10.3389/fimmu.2023.1079495. PMID: 37077908Free PMC Article
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Inflammation and cancer.
Murata M
Environ Health Prev Med 2018 Oct 20;23(1):50. doi: 10.1186/s12199-018-0740-1. PMID: 30340457Free PMC Article
Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.
Johnson AD, Cohn CS
Clin Microbiol Rev 2016 Oct;29(4):749-57. doi: 10.1128/CMR.00086-15. PMID: 27358491Free PMC Article

Therapy

Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial.
Meng F, Zhao J, Tan AT, Hu W, Wang SY, Jin J, Wu J, Li Y, Shi L, Fu JL, Yu S, Shen Y, Liu L, Luan J, Shi M, Xie Y, Zhou CB, Wong RW, Lu-En W, Koh S, Bertoletti A, Wang T, Zhang JY, Wang FS
Hepatol Int 2021 Dec;15(6):1402-1412. Epub 2021 Nov 30 doi: 10.1007/s12072-021-10250-2. PMID: 34850325Free PMC Article
Human papilloma virus-related premalignant and malignant lesions of the cervix and anogenital tract in immunocompromised women.
Wielgos AA, Pietrzak B
Ginekol Pol 2020;91(1):32-37. doi: 10.5603/GP.2020.0008. PMID: 32039466
Advances in Radiation Oncology: What to Consider.
Hegde JV, Chen AM, Chin RK
Otolaryngol Clin North Am 2017 Aug;50(4):755-764. Epub 2017 May 17 doi: 10.1016/j.otc.2017.03.011. PMID: 28527523

Prognosis

Sequencing Systemic Therapy in Hepatocellular Carcinoma.
Ponvilawan B, Roth MT
Curr Treat Options Oncol 2023 Nov;24(11):1580-1597. Epub 2023 Oct 16 doi: 10.1007/s11864-023-01135-7. PMID: 37843628
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Translational Regulation in Hepatocellular Carcinogenesis.
Bracic Tomazic S, Schatz C, Haybaeck J
Drug Des Devel Ther 2021;15:4359-4369. Epub 2021 Oct 14 doi: 10.2147/DDDT.S255582. PMID: 34703211Free PMC Article
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma.
Han YF, Zhao J, Ma LY, Yin JH, Chang WJ, Zhang HW, Cao GW
World J Gastroenterol 2011 Oct 14;17(38):4258-70. doi: 10.3748/wjg.v17.i38.4258. PMID: 22090781Free PMC Article
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Clinical prediction guides

Sequencing Systemic Therapy in Hepatocellular Carcinoma.
Ponvilawan B, Roth MT
Curr Treat Options Oncol 2023 Nov;24(11):1580-1597. Epub 2023 Oct 16 doi: 10.1007/s11864-023-01135-7. PMID: 37843628
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Translational Regulation in Hepatocellular Carcinogenesis.
Bracic Tomazic S, Schatz C, Haybaeck J
Drug Des Devel Ther 2021;15:4359-4369. Epub 2021 Oct 14 doi: 10.2147/DDDT.S255582. PMID: 34703211Free PMC Article
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Recent systematic reviews

Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis.
Yu B, Zhi X, Li Q, Li T, Chen Z
BMC Gastroenterol 2023 Aug 23;23(1):289. doi: 10.1186/s12876-023-02925-x. PMID: 37612653Free PMC Article
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Effect of adjuvant interferon therapy on hepatitis B virus-related hepatocellular carcinoma: a systematic review.
Yang S, Lin Q, Lin W, Hu W, Wang G
World J Surg Oncol 2016 Jun 9;14(1):159. doi: 10.1186/s12957-016-0912-7. PMID: 27282382Free PMC Article
Efficacy of antiviral therapy with nucleotide/nucleoside analogs after curative treatment for patients with hepatitis B virus-related hepatocellular carcinoma: A systematic review and meta-analysis.
Xia BW, Zhang YC, Wang J, Ding FH, He XD
Clin Res Hepatol Gastroenterol 2015 Sep;39(4):458-68. Epub 2015 Jan 28 doi: 10.1016/j.clinre.2014.12.003. PMID: 25650304
A systematic review and meta-analysis of adjuvant interferon therapy after curative treatment for patients with viral hepatitis-related hepatocellular carcinoma.
Huang TS, Shyu YC, Chen HY, Yuan SS, Shih JN, Chen PJ
J Viral Hepat 2013 Oct;20(10):729-43. Epub 2013 Apr 16 doi: 10.1111/jvh.12096. PMID: 24010648

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