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Paroxysmal ventricular tachycardia

MedGen UID:
18315
Concept ID:
C0030591
Disease or Syndrome
Synonym: Episodes of ventricular tachycardia
SNOMED CT: Paroxysmal ventricular tachycardia (66657009)
 
HPO: HP:0004751

Definition

Episodes of ventricular tachycardia that have a sudden onset and ending. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParoxysmal ventricular tachycardia

Conditions with this feature

Familial ventricular tachycardia
MedGen UID:
83309
Concept ID:
C0340485
Disease or Syndrome
An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.
Naxos disease
MedGen UID:
321991
Concept ID:
C1832600
Disease or Syndrome
Naxos disease (NXD) is characterized by arrhythmogenic right ventricular cardiomyopathy associated with abnormalities of the skin, hair, and nails. The ectodermal features are evident from birth or early childhood, whereas the cardiac symptoms develop in young adulthood or later. Clinical variability of ectodermal features has been observed, with hair anomalies ranging from woolly hair to alopecia, and skin abnormalities ranging from mild focal palmoplantar keratoderma to generalized skin fragility or even lethal neonatal epidermolysis bullosa (Protonotarios et al., 1986; Cabral et al., 2010; Pigors et al., 2011; Erken et al., 2011; Sen-Chowdhry and McKenna, 2014). Another syndrome involving cardiomyopathy, woolly hair, and keratoderma (DCWHK; 605676) is caused by mutation in the desmoplakin gene (DSP; 125647). Also see 610476 for a similar disorder caused by homozygous mutation in the DSC2 gene (125645).
Glycogen storage disease XV
MedGen UID:
462104
Concept ID:
C3150754
Disease or Syndrome
Glycogen storage disease type 15 is an extremely rare genetic glycogen storage disease reported in one patient to date. Clinical signs included muscle weakness, cardiac arrhythmia associated with accumulation of abnormal storage material in the heart and glycogen depletion in skeletal muscle.
Catecholaminergic polymorphic ventricular tachycardia 3
MedGen UID:
462813
Concept ID:
C3151463
Disease or Syndrome
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic syncope occurring during exercise or acute emotion. The underlying cause of these episodes is the onset of fast ventricular tachycardia (bidirectional or polymorphic). Spontaneous recovery may occur when these arrhythmias self-terminate. In other instances, ventricular tachycardia may degenerate into ventricular fibrillation and cause sudden death if cardiopulmonary resuscitation is not readily available. The mean onset of symptoms (usually a syncopal episode) is between age seven and 12 years; onset as late as the fourth decade of life has been reported. If untreated, CPVT is highly lethal, as approximately 30% of affected individuals experience at least one cardiac arrest and up to 80% have one or more syncopal spells. Sudden death may be the first manifestation of the disease.
Cardiomyopathy, dilated, 2G
MedGen UID:
1801983
Concept ID:
C5676995
Disease or Syndrome
Dilated cardiomyopathy-2G (CMD2G) is characterized by early-onset severe dilated cardiomyopathy that progresses rapidly to heart failure in the neonatal period without evidence of intervening hypertrophy. Cardiac tissue exhibits markedly shortened thin filaments, disorganized myofibrils, and reduced contractile force generation, resulting in the severe ventricular dysfunction observed. There is no evidence of skeletal muscle hypertrophy (Ahrens-Nicklas et al., 2019). For a general phenotypic description and a discussion of genetic heterogeneity of dilated cardiomyopathy, see 115200.

Professional guidelines

PubMed

Kay GN, Epstein AE, Bubien RS, Anderson PG, Dailey SM, Plumb VJ
J Am Coll Cardiol 1992 Jan;19(1):159-68. doi: 10.1016/0735-1097(92)90068-x. PMID: 1729328
Wyndham CR
Am J Cardiol 1988 Nov 3;62(14):13I-17I. doi: 10.1016/0002-9149(88)91342-2. PMID: 3055915
Kerr CR, Klein GJ, Cooper JA, Sharma AD
Cardiovasc Clin 1985;16(1):215-37. PMID: 3915712

Recent clinical studies

Etiology

Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Dahlin AA, Parsons CC, Barengo NC, Ruiz JG, Ward-Peterson M, Zevallos JC
Medicine (Baltimore) 2017 Jul;96(28):e7403. doi: 10.1097/MD.0000000000007403. PMID: 28700475Free PMC Article
Alvarez E, Jiménez J, Moleiro F, Rodríguez A
Med Eng Phys 2010 Dec;32(10):1131-6. Epub 2010 Sep 24 doi: 10.1016/j.medengphy.2010.08.004. PMID: 20869900
Trippel DL, Gillette PC
Am Heart J 1990 Jun;119(6):1312-6. doi: 10.1016/s0002-8703(05)80180-2. PMID: 2353617
Hernandez A, Strauss A, Kleiger RE, Goldring D
J Pediatr 1975 Feb;86(2):182-8. doi: 10.1016/s0022-3476(75)80464-1. PMID: 1111679

Diagnosis

Cao J, Xu Q, Liu Y, Yi J, Shi R
Medicine (Baltimore) 2020 Mar;99(11):e19147. doi: 10.1097/MD.0000000000019147. PMID: 32176041Free PMC Article
Dahlin AA, Parsons CC, Barengo NC, Ruiz JG, Ward-Peterson M, Zevallos JC
Medicine (Baltimore) 2017 Jul;96(28):e7403. doi: 10.1097/MD.0000000000007403. PMID: 28700475Free PMC Article
Reddy CP, Sartini JC, Kuo CS
J Electrocardiol 1982 Oct;15(4):403-10. doi: 10.1016/s0022-0736(82)81016-9. PMID: 7142878
Hernandez A, Strauss A, Kleiger RE, Goldring D
J Pediatr 1975 Feb;86(2):182-8. doi: 10.1016/s0022-3476(75)80464-1. PMID: 1111679
Sacks HS, Matisonn R, Kennelly BM
Am Heart J 1974 Feb;87(2):217-22. doi: 10.1016/0002-8703(74)90044-1. PMID: 4129426

Therapy

Cao J, Xu Q, Liu Y, Yi J, Shi R
Medicine (Baltimore) 2020 Mar;99(11):e19147. doi: 10.1097/MD.0000000000019147. PMID: 32176041Free PMC Article
Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Coelho A, Palileo E, Ashley W, Swiryn S, Petropoulos AT, Welch WJ, Bauernfeind RA
J Am Coll Cardiol 1986 Jan;7(1):237-43. doi: 10.1016/s0735-1097(86)80287-x. PMID: 3941211
Bauman JL, Gallastegui J, Prechel D, Anderson JL
Pharmacotherapy 1986 Jul-Aug;6(4):184-92. doi: 10.1002/j.1875-9114.1986.tb03474.x. PMID: 3774563
Zipes DP, Orgain ES
Ann Intern Med 1967 Dec;67(6):1251-7. doi: 10.7326/0003-4819-67-6-1251. PMID: 6061939

Prognosis

Dahlin AA, Parsons CC, Barengo NC, Ruiz JG, Ward-Peterson M, Zevallos JC
Medicine (Baltimore) 2017 Jul;96(28):e7403. doi: 10.1097/MD.0000000000007403. PMID: 28700475Free PMC Article
De Bruin ML, van Hemel NM, Leufkens HG, Hoes AW
J Clin Epidemiol 2005 Dec;58(12):1325-9. Epub 2005 Sep 12 doi: 10.1016/j.jclinepi.2005.04.009. PMID: 16291479
Kerr CR, Klein GJ, Cooper JA, Sharma AD
Cardiovasc Clin 1985;16(1):215-37. PMID: 3915712
de Soyza N, Bennett FA, Murphy ML, Bissett JK, Kane JJ
Am J Med 1978 Mar;64(3):377-81. doi: 10.1016/0002-9343(78)90215-2. PMID: 637052
Hernandez A, Strauss A, Kleiger RE, Goldring D
J Pediatr 1975 Feb;86(2):182-8. doi: 10.1016/s0022-3476(75)80464-1. PMID: 1111679

Clinical prediction guides

Joki N, Tokumoto M, Takahashi N, Nishimura M
Contrib Nephrol 2018;196:5-12. Epub 2018 Jul 24 doi: 10.1159/000485690. PMID: 30041198
Frolov AV, Vaikhanskaya TG, Melnikova OP, Vorobiev AP, Guel LM
Kardiol Pol 2017;75(7):682-688. doi: 10.5603/KP.a2017.0060. PMID: 28708197
Kim SY, Benowitz NL
Drug Saf 1990 Nov-Dec;5(6):393-420. doi: 10.2165/00002018-199005060-00002. PMID: 2285495
Kerr CR, Klein GJ, Cooper JA, Sharma AD
Cardiovasc Clin 1985;16(1):215-37. PMID: 3915712
Hernandez A, Strauss A, Kleiger RE, Goldring D
J Pediatr 1975 Feb;86(2):182-8. doi: 10.1016/s0022-3476(75)80464-1. PMID: 1111679

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