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Autoinflammatory disease, systemic, with vasculitis(SAIDV)

MedGen UID:
1841161
Concept ID:
C5830525
Disease or Syndrome
Synonyms: LAVLI SYNDROME; SAIDV
 
Gene (location): LYN (8q12.1)
 
Monarch Initiative: MONDO:0957271
OMIM®: 620376

Definition

Systemic autoinflammatory disease with vasculitis (SAIDV) is an autosomal dominant disorder that manifests soon after birth with features such as purpuric skin rash, fever, hepatosplenomegaly, and elevated C-reactive protein (CRP; 123260). Laboratory studies may show leukocytosis, thrombocytopenia, and autoantibodies. A subset of patients develop progressive liver involvement that may result in fibrosis. Other systemic features, such as periorbital edema, conjunctivitis, infections, abdominal pain, and arthralgia are usually observed. Mutations occur de novo. De Jesus et al. (2023) referred to this disorder as LAVLI (LYN kinase-associated vasculopathy and liver fibrosis). [from OMIM]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Arthralgia
MedGen UID:
13917
Concept ID:
C0003862
Sign or Symptom
Joint pain.
Fatigue
MedGen UID:
41971
Concept ID:
C0015672
Sign or Symptom
A subjective feeling of tiredness characterized by a lack of energy and motivation.
Congenital hydrocele
MedGen UID:
510693
Concept ID:
C0159015
Congenital Abnormality
Congenital hydrocele occurs when processus vaginalis is patent and communicates with the peritoneal cavity. This communication allows the movement of peritoneal fluid but is too small to allow the intra-abdominal contents to herniate through.
Cardiomegaly
MedGen UID:
5459
Concept ID:
C0018800
Finding
Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography.
Ascending tubular aorta aneurysm
MedGen UID:
163631
Concept ID:
C0856747
Anatomical Abnormality
An abnormal localized widening (dilatation) of the tubular part of the ascending aorta.
Small vessel vasculitis
MedGen UID:
868710
Concept ID:
C4023113
Disease or Syndrome
A type of vasculitis (inflammation of blood vessel walls) that affects blood vessels that are smaller than arteries, i.e., arterioles, venules, and capilllaries.
Fetal growth restriction
MedGen UID:
4693
Concept ID:
C0015934
Pathologic Function
An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
Failure to thrive
MedGen UID:
746019
Concept ID:
C2315100
Disease or Syndrome
Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
Cholestasis
MedGen UID:
925
Concept ID:
C0008370
Disease or Syndrome
Impairment of bile flow due to obstruction in bile ducts.
Colitis
MedGen UID:
40385
Concept ID:
C0009319
Disease or Syndrome
Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface (epithelium) of the rectum and colon. The rectum and colon make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between the age of 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout a person's life, which causes recurring signs and symptoms.\n\nThe most common symptoms of ulcerative colitis are cramping abdominal pain and frequent diarrhea, often with blood, pus, or mucus in the stool. Other signs and symptoms include nausea, loss of appetite, bowel urgency, fatigue, and fevers. Chronic bleeding from the inflamed and ulcerated intestinal tissue can cause a shortage of red blood cells (anemia) in some affected individuals. People with this disorder have difficulty absorbing enough fluids and nutrients from their diet and often experience weight loss. Affected children usually grow more slowly than normal. Less commonly, ulcerative colitis causes problems with the skin, joints, eyes, kidneys, or liver, which are most likely due to abnormal inflammation.\n\nToxic megacolon is a rare complication of ulcerative colitis that can be life-threatening. Toxic megacolon involves a widening (dilation) of the colon and an overwhelming inflammatory response. Ulcerative colitis also increases the risk of developing colon cancer, especially in people whose entire colon is inflamed and in those who have had ulcerative colitis for 8 years or more.\n\nUlcerative colitis is one common form of inflammatory bowel disease (IBD). Another type of IBD, Crohn's disease, also causes chronic inflammation of the intestines. Unlike ulcerative colitis, which affects only the inner surface of the large intestine, Crohn's disease can cause inflammation in any part of the digestive system, and the inflammation extends deeper into the intestinal tissue.
Diarrhea
MedGen UID:
8360
Concept ID:
C0011991
Sign or Symptom
Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.
Hepatomegaly
MedGen UID:
42428
Concept ID:
C0019209
Finding
Abnormally increased size of the liver.
Hepatosplenomegaly
MedGen UID:
9225
Concept ID:
C0019214
Sign or Symptom
Simultaneous enlargement of the liver and spleen.
Jaundice
MedGen UID:
43987
Concept ID:
C0022346
Sign or Symptom
Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.
Hepatic fibrosis
MedGen UID:
116093
Concept ID:
C0239946
Disease or Syndrome
The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process.
Hepatic calcification
MedGen UID:
490154
Concept ID:
C1696466
Disease or Syndrome
The presence of abnormal calcium deposition in the liver.
Headache
MedGen UID:
9149
Concept ID:
C0018681
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
Anemia
MedGen UID:
1526
Concept ID:
C0002871
Disease or Syndrome
A reduction in erythrocytes volume or hemoglobin concentration.
Thrombocytopenia
MedGen UID:
52737
Concept ID:
C0040034
Disease or Syndrome
A reduction in the number of circulating thrombocytes.
Arthritis
MedGen UID:
2043
Concept ID:
C0003864
Disease or Syndrome
Inflammation of a joint.
Frontal bossing
MedGen UID:
67453
Concept ID:
C0221354
Congenital Abnormality
Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.
Asthma
MedGen UID:
2109
Concept ID:
C0004096
Disease or Syndrome
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
Conjunctivitis
MedGen UID:
1093
Concept ID:
C0009763
Disease or Syndrome
Inflammation of the conjunctiva.
Atopic eczema
MedGen UID:
41502
Concept ID:
C0011615
Disease or Syndrome
Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007). Genetic Heterogeneity of Atopic Dermatitis Many inflammatory diseases, such as atopic eczema, are genetically complex, with multiple alleles at several loci thought to be involved in their pathogenesis. Several susceptibility loci for atopic dermatitis have been identified: ATOD1 on chromosome 3q21, ATOD2 (605803) on chromosome 1q21, ATOD3 (605804) on chromosome 20p, ATOD4 (605805) on chromosome 17q25.3, ATOD5 (603165) on chromosome 13q12-q14, ATOD6 (605845) on chromosome 5q31-q33, ATOD7 (613064) on chromosome 11q13.5, ATOD8 (613518) on chromosome 4q22.1, and ATOD9 (613519) on chromosome 3p24.
Epididymitis
MedGen UID:
4986
Concept ID:
C0014534
Disease or Syndrome
The presence of inflammation of the epididymis.
Leukocytosis
MedGen UID:
9736
Concept ID:
C0023518
Disease or Syndrome
An abnormal increase in the number of leukocytes in the blood.
Splenomegaly
MedGen UID:
52469
Concept ID:
C0038002
Finding
Abnormal increased size of the spleen.
Rheumatoid factor positive
MedGen UID:
56226
Concept ID:
C0151379
Laboratory or Test Result
The presence in the serum of an autoantibody directed against the Fc portion of IgG.
Decreased circulating IgA level
MedGen UID:
57934
Concept ID:
C0162538
Disease or Syndrome
Decreased levels of immunoglobulin A (IgA).
Decreased circulating total IgM
MedGen UID:
116095
Concept ID:
C0239989
Finding
An abnormally decreased level of immunoglobulin M (IgM) in blood.
Increased B cell count
MedGen UID:
349067
Concept ID:
C1858972
Finding
An abnormal increase from the normal count of B cells.
Antimitochondrial antibody positivity
MedGen UID:
866704
Concept ID:
C4021051
Finding
The presence of autoantibodies (immunoglobulins) in the serum that react against mitochondria.
Increased T cell count
MedGen UID:
867575
Concept ID:
C4021960
Finding
An abnormal increase in the total number of T cells detected in the blood.
Increased circulating interleukin 6 concentration
MedGen UID:
901461
Concept ID:
C4280771
Finding
The concentration of interleukin-6 in the blood circulation is above the upper limit of normal.
Lupus anticoagulant
MedGen UID:
1370558
Concept ID:
C4321325
Finding
Presence of lupus anticoagulant (LA) autoantibodies. LA represent a heterogeneous group of autoantibodies, IgG, IgM, or a mixture of both classes, that interfere with standard phospholipid-based coagulant tests (this is only an in vitro phenomenon, LA do not cause reduction of coagulation in vivo). The antibodies are directed against plasma proteins which also bind to phospholipid surfaces.
Anti-thyroid peroxidase antibody positivity
MedGen UID:
1392952
Concept ID:
C4476743
Laboratory or Test Result
The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase.
Abnormal circulating IgG level
MedGen UID:
1687987
Concept ID:
C5139422
Finding
An abnormal deviation from normal levels of IgG immunoglobulin in blood.
Anti-Sm antibody positivity
MedGen UID:
1755112
Concept ID:
C5421567
Finding
The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles.
Fever
MedGen UID:
5169
Concept ID:
C0015967
Sign or Symptom
Body temperature elevated above the normal range.
Elevated erythrocyte sedimentation rate
MedGen UID:
57727
Concept ID:
C0151632
Finding
An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
Elevated circulating aspartate aminotransferase concentration
MedGen UID:
57497
Concept ID:
C0151904
Finding
The concentration of aspartate aminotransferase (AST) in the blood circulation is above the upper limit of normal.
Elevated circulating alanine aminotransferase concentration
MedGen UID:
57740
Concept ID:
C0151905
Finding
An abnormally high concentration in the circulation of alanine aminotransferase (ALT).
Conjugated hyperbilirubinemia
MedGen UID:
82787
Concept ID:
C0268307
Disease or Syndrome
Abnormally high level of conjugated bilirubin in the blood.
Elevated circulating C-reactive protein concentration
MedGen UID:
892906
Concept ID:
C4023452
Finding
An abnormal elevation of the C-reactive protein level in the blood circulation.
Elevated gamma-glutamyltransferase level
MedGen UID:
1370086
Concept ID:
C4476869
Finding
Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
Parotitis
MedGen UID:
45335
Concept ID:
C0030583
Disease or Syndrome
Inflammation of the parotid gland.
Oral ulcer
MedGen UID:
57699
Concept ID:
C0149745
Disease or Syndrome
Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue.
Periorbital edema
MedGen UID:
56223
Concept ID:
C0151205
Pathologic Function
Edema affecting the region situated around the orbit of the eye.
Purpura
MedGen UID:
19584
Concept ID:
C0034150
Disease or Syndrome
Purpura (from Latin
Erythema
MedGen UID:
11999
Concept ID:
C0041834
Disease or Syndrome
Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.
Urticaria
MedGen UID:
22587
Concept ID:
C0042109
Disease or Syndrome
Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
Hydrops fetalis
MedGen UID:
6947
Concept ID:
C0020305
Disease or Syndrome
The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.
Premature birth
MedGen UID:
57721
Concept ID:
C0151526
Pathologic Function
The birth of a baby of less than 37 weeks of gestational age.
Hypertelorism
MedGen UID:
9373
Concept ID:
C0020534
Finding
Although hypertelorism means an excessive distance between any paired organs (e.g., the nipples), the use of the word has come to be confined to ocular hypertelorism. Hypertelorism occurs as an isolated feature and is also a feature of many syndromes, e.g., Opitz G syndrome (see 300000), Greig cephalopolysyndactyly (175700), and Noonan syndrome (163950) (summary by Cohen et al., 1995).

Professional guidelines

PubMed

Burns E, Cooper E, Peterson R, Diaz LZ
Pediatr Dermatol 2022 Mar;39(2):173-181. Epub 2022 Jan 20 doi: 10.1111/pde.14859. PMID: 35060179
Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA
Autoimmun Rev 2021 Mar;20(3):102763. Epub 2021 Jan 20 doi: 10.1016/j.autrev.2021.102763. PMID: 33482337
Sota J, Rigante D, Lopalco G, Frediani B, Franceschini R, Galeazzi M, Iannone F, Tosi GM, Fabiani C, Cantarini L
Rheumatol Int 2018 Jan;38(1):25-35. Epub 2017 Jul 27 doi: 10.1007/s00296-017-3775-5. PMID: 28752230

Recent clinical studies

Etiology

Gutierrez-Rodrigues F, Kusne Y, Fernandez J, Lasho T, Shalhoub R, Ma X, Alessi H, Finke C, Koster MJ, Mangaonkar A, Warrington KJ, Begna K, Xie Z, Ombrello AK, Viswanatha D, Ferrada M, Wilson L, Go R, Kourelis T, Reichard K, Olteanu H, Darden I, Hironaka D, Alemu L, Kajigaya S, Rosenzweig S, Calado RT, Groarke EM, Kastner DL, Calvo KR, Wu CO, Grayson PC, Young NS, Beck DB, Patel BA, Patnaik MM
Blood 2023 Jul 20;142(3):244-259. doi: 10.1182/blood.2022018774. PMID: 37084382Free PMC Article
Li GM, Han X, Wu Y, Wang W, Tang HX, Lu MP, Tang XM, Lin Y, Deng F, Yang J, Wang XN, Liu CC, Zheng WJ, Wu BB, Zhou F, Luo H, Zhang L, Liu HM, Guan WZ, Wang SH, Tao PF, Jin TJ, Fang R, Wu Y, Zhang J, Zhang Y, Zhang TN, Yin W, Guo L, Tang WJ, Chang H, Zhang QY, Li XZ, Li JG, Zhou ZX, Yang SR, Yang KK, Xu H, Song HM, Deuitch NT, Lee PY, Zhou Q, Sun L
J Clin Immunol 2023 May;43(4):835-845. Epub 2023 Feb 18 doi: 10.1007/s10875-023-01432-8. PMID: 36807221Free PMC Article
Jo YG, Ortiz-Fernández L, Coit P, Yilmaz V, Yentür SP, Alibaz-Oner F, Aksu K, Erken E, Düzgün N, Keser G, Cefle A, Yazici A, Ergen A, Alpsoy E, Salvarani C, Kısacık B, Kötter I, Henes J, Çınar M, Schaefer A, Nohutcu RM, Takeuchi F, Harihara S, Kaburaki T, Messedi M, Song YW, Kaşifoğlu T, Martin J, González Escribano MF, Saruhan-Direskeneli G, Direskeneli H, Sawalha AH
J Autoimmun 2022 Oct;132:102882. Epub 2022 Aug 18 doi: 10.1016/j.jaut.2022.102882. PMID: 35987173Free PMC Article
Hochman MJ, DeZern AE
Lancet Haematol 2022 Jul;9(7):e523-e534. doi: 10.1016/S2352-3026(22)00138-7. PMID: 35772431
Lopalco G, Rigante D, Venerito V, Emmi G, Anelli MG, Lapadula G, Iannone F, Cantarini L
Curr Rheumatol Rep 2016 Jun;18(6):36. doi: 10.1007/s11926-016-0580-1. PMID: 27118389

Diagnosis

Wang RX, Newman SA
Immunol Allergy Clin North Am 2024 Aug;44(3):483-502. Epub 2024 May 19 doi: 10.1016/j.iac.2024.03.006. PMID: 38937011
Hochman MJ, DeZern AE
Lancet Haematol 2022 Jul;9(7):e523-e534. doi: 10.1016/S2352-3026(22)00138-7. PMID: 35772431
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Davis MDP, van der Hilst JCH
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1162-1170. Epub 2018 Jun 2 doi: 10.1016/j.jaip.2018.05.006. PMID: 29871797
Bulur I, Onder M
Clin Dermatol 2017 Sep-Oct;35(5):421-434. Epub 2017 Jun 27 doi: 10.1016/j.clindermatol.2017.06.004. PMID: 28916023

Therapy

Wang RX, Newman SA
Immunol Allergy Clin North Am 2024 Aug;44(3):483-502. Epub 2024 May 19 doi: 10.1016/j.iac.2024.03.006. PMID: 38937011
Soriano A, Soriano M, Espinosa G, Manna R, Emmi G, Cantarini L, Hernández-Rodríguez J
Front Immunol 2020;11:865. Epub 2020 Jun 3 doi: 10.3389/fimmu.2020.00865. PMID: 32655539Free PMC Article
Bergantini L, d'Alessandro M, Cameli P, Vietri L, Vagaggini C, Perrone A, Sestini P, Frediani B, Bargagli E
Clin Rheumatol 2020 May;39(5):1415-1421. Epub 2020 Feb 22 doi: 10.1007/s10067-020-04996-7. PMID: 32088800
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Lopalco G, Rigante D, Venerito V, Emmi G, Anelli MG, Lapadula G, Iannone F, Cantarini L
Curr Rheumatol Rep 2016 Jun;18(6):36. doi: 10.1007/s11926-016-0580-1. PMID: 27118389

Prognosis

Gutierrez-Rodrigues F, Kusne Y, Fernandez J, Lasho T, Shalhoub R, Ma X, Alessi H, Finke C, Koster MJ, Mangaonkar A, Warrington KJ, Begna K, Xie Z, Ombrello AK, Viswanatha D, Ferrada M, Wilson L, Go R, Kourelis T, Reichard K, Olteanu H, Darden I, Hironaka D, Alemu L, Kajigaya S, Rosenzweig S, Calado RT, Groarke EM, Kastner DL, Calvo KR, Wu CO, Grayson PC, Young NS, Beck DB, Patel BA, Patnaik MM
Blood 2023 Jul 20;142(3):244-259. doi: 10.1182/blood.2022018774. PMID: 37084382Free PMC Article
Bergantini L, d'Alessandro M, Cameli P, Vietri L, Vagaggini C, Perrone A, Sestini P, Frediani B, Bargagli E
Clin Rheumatol 2020 May;39(5):1415-1421. Epub 2020 Feb 22 doi: 10.1007/s10067-020-04996-7. PMID: 32088800
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Baldovino S, Menegatti E, Roccatello D, Sciascia S
Adv Exp Med Biol 2017;1031:497-509. doi: 10.1007/978-3-319-67144-4_26. PMID: 29214588
Caso F, Costa L, Rigante D, Lucherini OM, Caso P, Bascherini V, Frediani B, Cimaz R, Marrani E, Nieves-Martín L, Atteno M, Raffaele CG, Tarantino G, Galeazzi M, Punzi L, Cantarini L
Mediators Inflamm 2014;2014:107421. Epub 2014 Jun 30 doi: 10.1155/2014/107421. PMID: 25061259Free PMC Article

Clinical prediction guides

Tarsia M, Gaggiano C, Gessaroli E, Grosso S, Tosi GM, Frediani B, Cantarini L, Fabiani C
Ocul Immunol Inflamm 2023 Jan;31(1):175-184. Epub 2022 Feb 28 doi: 10.1080/09273948.2021.2023582. PMID: 35226583
Jo YG, Ortiz-Fernández L, Coit P, Yilmaz V, Yentür SP, Alibaz-Oner F, Aksu K, Erken E, Düzgün N, Keser G, Cefle A, Yazici A, Ergen A, Alpsoy E, Salvarani C, Kısacık B, Kötter I, Henes J, Çınar M, Schaefer A, Nohutcu RM, Takeuchi F, Harihara S, Kaburaki T, Messedi M, Song YW, Kaşifoğlu T, Martin J, González Escribano MF, Saruhan-Direskeneli G, Direskeneli H, Sawalha AH
J Autoimmun 2022 Oct;132:102882. Epub 2022 Aug 18 doi: 10.1016/j.jaut.2022.102882. PMID: 35987173Free PMC Article
Bergantini L, d'Alessandro M, Cameli P, Vietri L, Vagaggini C, Perrone A, Sestini P, Frediani B, Bargagli E
Clin Rheumatol 2020 May;39(5):1415-1421. Epub 2020 Feb 22 doi: 10.1007/s10067-020-04996-7. PMID: 32088800
Papadopoulou C, Omoyinmi E, Standing A, Pain CE, Booth C, D'Arco F, Gilmour K, Buckland M, Eleftheriou D, Brogan PA
Rheumatology (Oxford) 2019 Jul 1;58(7):1227-1238. doi: 10.1093/rheumatology/key445. PMID: 30715505
Fabiani C, Vitale A, Emmi G, Lopalco G, Vannozzi L, Guerriero S, Gentileschi S, Bacherini D, Franceschini R, Frediani B, Galeazzi M, Iannone F, Tosi GM, Cantarini L
Clin Rheumatol 2017 Jan;36(1):191-197. Epub 2016 Dec 16 doi: 10.1007/s10067-016-3506-4. PMID: 27981463

Recent systematic reviews

Altom A, Khader SAE, Gad AG, Anadani R, Dang DP, Ansar F, Chaudhari J, Crespo-Quezada J, Huy NT
Am J Dermatopathol 2023 Jun 1;45(6):355-370. Epub 2023 Feb 17 doi: 10.1097/DAD.0000000000002345. PMID: 37191371
Nayir Buyuksahin H, Basaran O, Balık Z, Bilginer Y, Ozen S, Dogru D
Pediatr Pulmonol 2023 Feb;58(2):367-373. Epub 2022 Nov 7 doi: 10.1002/ppul.26220. PMID: 36314652
Abbara S, Grateau G, Ducharme-Bénard S, Saadoun D, Georgin-Lavialle S
Front Immunol 2019;10:763. Epub 2019 Apr 12 doi: 10.3389/fimmu.2019.00763. PMID: 31031761Free PMC Article
Bettiol A, Silvestri E, Di Scala G, Amedei A, Becatti M, Fiorillo C, Lopalco G, Salvarani C, Cantarini L, Soriano A, Emmi G
Rheumatol Int 2019 Jun;39(6):971-990. Epub 2019 Feb 25 doi: 10.1007/s00296-019-04259-y. PMID: 30799530
Berteau F, Rouviere B, Delluc A, Nau A, Le Berre R, Sarrabay G, Touitou I, de Moreuil C
Autoimmun Rev 2018 Aug;17(8):809-815. Epub 2018 Jun 8 doi: 10.1016/j.autrev.2018.02.012. PMID: 29890348

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