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Abnormal circulating alpha-fetoprotein concentration

MedGen UID:
1841543
•Concept ID:
C5826838
•
Finding
HPO: HP:0045056

Definition

Concentration of alpha-fetoprotein in the blood circulation outside normal limits. [from HPO]

Recent clinical studies

Etiology

Evaluation of serum tumour markers concentrations in patients with homozygous beta-thalassaemia in relation to demographical, clinical and biochemical parameters.
Christoforidis A, Lefkou E, Vlachaki E, Perifanis V, Tsatra I, Dogramatzi F, Athanassiou-Metaxa M
Ann Hematol 2007 Nov;86(11):837-41. Epub 2007 Aug 1 doi: 10.1007/s00277-007-0348-9. PMID: 17668208
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Benn PA
Clin Chim Acta 2002 Sep;323(1-2):1-16. doi: 10.1016/s0009-8981(02)00186-9. PMID: 12135803
The proform of eosinophil major basic protein: a new maternal serum marker for Down syndrome.
Christiansen M, Oxvig C, Wagner JM, Qin QP, Nguyen TH, Overgaard MT, Larsen SO, Sottrup-Jensen L, Gleich GJ, Norgaard-Pedersen B
Prenat Diagn 1999 Oct;19(10):905-10. doi: 10.1002/(sici)1097-0223(199910)19:10<905::aid-pd658>3.0.co;2-q. PMID: 10521813
Evaluation of elevations in maternal serum alpha-fetoprotein: a review.
Thomas RL, Blakemore KJ
Obstet Gynecol Surv 1990 May;45(5):269-83. PMID: 1692399
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease.
Shapiro B, Chakrabarty M, Cohn EM, Leon SA
Cancer 1983 Jun 1;51(11):2116-20. doi: 10.1002/1097-0142(19830601)51:11<2116::aid-cncr2820511127>3.0.co;2-s. PMID: 6188527

Diagnosis

Value of quantitative and qualitative analyses of circulating cell-free DNA as diagnostic tools for hepatocellular carcinoma: a meta-analysis.
Liao W, Mao Y, Ge P, Yang H, Xu H, Lu X, Sang X, Zhong S
Medicine (Baltimore) 2015 Apr;94(14):e722. doi: 10.1097/MD.0000000000000722. PMID: 25860220Free PMC Article
Alpha-fetoprotein, a fascinating protein and biomarker in neurology.
Schieving JH, de Vries M, van Vugt JM, Weemaes C, van Deuren M, Nicolai J, Wevers RA, Willemsen MA
Eur J Paediatr Neurol 2014 May;18(3):243-8. Epub 2013 Sep 29 doi: 10.1016/j.ejpn.2013.09.003. PMID: 24120489
Advances in prenatal screening for Down syndrome: I. general principles and second trimester testing.
Benn PA
Clin Chim Acta 2002 Sep;323(1-2):1-16. doi: 10.1016/s0009-8981(02)00186-9. PMID: 12135803
Evaluation of elevations in maternal serum alpha-fetoprotein: a review.
Thomas RL, Blakemore KJ
Obstet Gynecol Surv 1990 May;45(5):269-83. PMID: 1692399
Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood.
Wajner M, Papiha SS, Wagstaff TJ
J Perinat Med 1986;14(2):115-21. doi: 10.1515/jpme.1986.14.2.115. PMID: 2426436

Prognosis

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease.
Shapiro B, Chakrabarty M, Cohn EM, Leon SA
Cancer 1983 Jun 1;51(11):2116-20. doi: 10.1002/1097-0142(19830601)51:11<2116::aid-cncr2820511127>3.0.co;2-s. PMID: 6188527
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood.
Wajner M, Papiha SS, Wagstaff TJ
J Perinat Med 1986;14(2):115-21. doi: 10.1515/jpme.1986.14.2.115. PMID: 2426436
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

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