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Dermal immune complex deposition

MedGen UID:
1841613
•Concept ID:
C5826553
•
Finding
HPO: HP:0034643

Definition

Accumulation of antigen-bound antibody in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermal immune complex deposition

Professional guidelines

PubMed

Mesoglycan treatment restores defective fibrinolytic potential in cutaneous necrotizing venulitis.
Lotti T, Celasco G, Tsampau D, Teofoli P, Benci M, Dahm M, Comacchi C, Ghersetich I, Matucci-Cerinic M
Int J Dermatol 1993 May;32(5):368-71. doi: 10.1111/j.1365-4362.1993.tb01477.x. PMID: 8505166
Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. Influence of anti-rheumatic treatment.
Ullman S, Høier-Madsen M, Halberg P, Jans H, Sylvest J
Scand J Rheumatol 1979;8(2):119-23. doi: 10.3109/03009747909105349. PMID: 377474

Recent clinical studies

Etiology

Hardness and Painful Lesion of the Breast.
Vilas-Sueiro A, González-Vilas D, Aguilera C, Monteagudo B, De Las Heras C
Acta Dermatovenerol Croat 2017 Dec;25(4):305-306. PMID: 30064607
Vesicular Contact Reaction May Progress into Erythema Multiforme.
Czarnecka-Operacz M, Jenerowicz D, Szulczyńska-Gabor J, Teresiak-Mikołajczak E, Szyfter-Harris J, Bowszyc-Dmochowska M
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309. PMID: 28128086
Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease.
Alpsoy E, Uzun S, Akman A, Acar MA, Memişoglu HR, Başaran E
J Eur Acad Dermatol Venereol 2003 Sep;17(5):521-4. doi: 10.1046/j.1468-3083.2003.00625.x. PMID: 12941085
Quantitative analysis of immunocomplex deposits in the skin of patients with collagenosis.
Gligora M, Dorić M, Linić-Vlahović V, Dobrić I
Folia Biol (Praha) 1989;35(3):152-5. PMID: 2673847
Is Henoch-Schönlein purpura the systemic form of IgA nephropathy?
Waldo FB
Am J Kidney Dis 1988 Nov;12(5):373-7. doi: 10.1016/s0272-6386(88)80028-3. PMID: 3055961

Diagnosis

Koebnerization as a cutaneous manifestation of immune complex-mediated vasculitis.
Chan LS, Cooper KD, Rasmussen JE
J Am Acad Dermatol 1990 May;22(5 Pt 1):775-81. doi: 10.1016/0190-9622(90)70108-t. PMID: 2347963
Dermatitis herpetiformis: the skin and the gut.
Katz SI, Hall RP 3rd, Lawley TJ, Strober W
Ann Intern Med 1980 Dec;93(6):857-74. doi: 10.7326/0003-4819-93-6-857. PMID: 7447195
Cutaneous lesions after intestinal bypass.
Drenick EJ, Ahmed AR, Greenway F, Olerud JE
Ann Intern Med 1980 Oct;93(4):557-9. doi: 10.7326/0003-4819-93-4-557. PMID: 7001972
Pityriasis lichenoides--an immune complex disease.
Clayton R, Haffenden G, Du Vivier A, Burton J, Mowbray J
Br J Dermatol 1977 Dec;97(6):629-34. doi: 10.1111/j.1365-2133.1977.tb14269.x. PMID: 146510
Allopurinol hypersensitivity. Granular deposition of IgM at the dermal-epidermal junction.
Utsinger PD, Young WJ
Am J Med 1976 Aug;61(2):287-94. doi: 10.1016/0002-9343(76)90179-0. PMID: 952299

Therapy

Koebnerization as a cutaneous manifestation of immune complex-mediated vasculitis.
Chan LS, Cooper KD, Rasmussen JE
J Am Acad Dermatol 1990 May;22(5 Pt 1):775-81. doi: 10.1016/0190-9622(90)70108-t. PMID: 2347963
Idiopathic atrophie blanche.
Shornick JK, Nicholes BK, Bergstresser PR, Gilliam JN
J Am Acad Dermatol 1983 Jun;8(6):792-8. doi: 10.1016/s0190-9622(83)80008-5. PMID: 6345609
Reversal of microvascular abnormalities in a successfully treated case of leukocytoclastic vasculitis.
Kitchens CS
Johns Hopkins Med J 1980 Sep;147(3):97-101. PMID: 7412072
Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. Influence of anti-rheumatic treatment.
Ullman S, Høier-Madsen M, Halberg P, Jans H, Sylvest J
Scand J Rheumatol 1979;8(2):119-23. doi: 10.3109/03009747909105349. PMID: 377474
Allopurinol hypersensitivity. Granular deposition of IgM at the dermal-epidermal junction.
Utsinger PD, Young WJ
Am J Med 1976 Aug;61(2):287-94. doi: 10.1016/0002-9343(76)90179-0. PMID: 952299

Prognosis

Hardness and Painful Lesion of the Breast.
Vilas-Sueiro A, González-Vilas D, Aguilera C, Monteagudo B, De Las Heras C
Acta Dermatovenerol Croat 2017 Dec;25(4):305-306. PMID: 30064607
Vesicular Contact Reaction May Progress into Erythema Multiforme.
Czarnecka-Operacz M, Jenerowicz D, Szulczyńska-Gabor J, Teresiak-Mikołajczak E, Szyfter-Harris J, Bowszyc-Dmochowska M
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309. PMID: 28128086
Evidence of immunopathological traces in mucormycosis: an autopsy case.
Kusaba G, Ohsawa I, Ishii M, Inoshita H, Ohi H, Horikoshi S, Takase M, Yamaguchi Y, Tomino Y
Clin Exp Nephrol 2010 Aug;14(4):396-400. Epub 2010 May 12 doi: 10.1007/s10157-010-0289-9. PMID: 20461433
Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease.
Alpsoy E, Uzun S, Akman A, Acar MA, Memişoglu HR, Başaran E
J Eur Acad Dermatol Venereol 2003 Sep;17(5):521-4. doi: 10.1046/j.1468-3083.2003.00625.x. PMID: 12941085
Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure.
Bielory L, Gascon P, Lawley TJ, Young NS, Frank MM
Medicine (Baltimore) 1988 Jan;67(1):40-57. PMID: 3257288

Clinical prediction guides

STAT6 gain-of-function variant exacerbates multiple allergic symptoms.
Takeuchi I, Yanagi K, Takada S, Uchiyama T, Igarashi A, Motomura K, Hayashi Y, Nagano N, Matsuoka R, Sugiyama H, Yoshioka T, Saito H, Kawai T, Miyaji Y, Inuzuka Y, Matsubara Y, Ohya Y, Shimizu T, Matsumoto K, Arai K, Nomura I, Kaname T, Morita H
J Allergy Clin Immunol 2023 May;151(5):1402-1409.e6. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.12.802. PMID: 36538978
Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
Emtenani S, Holtsche MM, Stahlkopf R, Seiler DL, Burn T, Liu H, Parker M, Yilmaz K, Dikmen HO, Lang MH, Sadik CD, Karsten CM, van Beek N, Ludwig RJ, Köhl J, Schmidt E
Front Immunol 2022;13:942493. Epub 2022 Nov 18 doi: 10.3389/fimmu.2022.942493. PMID: 36466856Free PMC Article
Cutaneous lesions after intestinal bypass.
Drenick EJ, Ahmed AR, Greenway F, Olerud JE
Ann Intern Med 1980 Oct;93(4):557-9. doi: 10.7326/0003-4819-93-4-557. PMID: 7001972
Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. Influence of anti-rheumatic treatment.
Ullman S, Høier-Madsen M, Halberg P, Jans H, Sylvest J
Scand J Rheumatol 1979;8(2):119-23. doi: 10.3109/03009747909105349. PMID: 377474
Pityriasis lichenoides--an immune complex disease.
Clayton R, Haffenden G, Du Vivier A, Burton J, Mowbray J
Br J Dermatol 1977 Dec;97(6):629-34. doi: 10.1111/j.1365-2133.1977.tb14269.x. PMID: 146510

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