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Small acrosomal area

MedGen UID:
1841800
Concept ID:
C5826677
Finding
HPO: HP:0034810

Definition

Reduction in size of the acrosome below the lower limit of normal. The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus. According to the World Health Organization criteria, the acrosome must be clearly visible, comprising approximately 40-70 percent of the sperm head. [from HPO]

Term Hierarchy

Recent clinical studies

Etiology

Ayaz A, Agarwal A, Sharma R, Kothandaraman N, Cakar Z, Sikka S
Andrologia 2018 Aug;50(6):e13015. Epub 2018 Apr 15 doi: 10.1111/and.13015. PMID: 29656391
Boitrelle F, Albert M, Petit JM, Ferfouri F, Wainer R, Bergere M, Bailly M, Vialard F, Selva J
Reprod Biomed Online 2013 Aug;27(2):201-11. Epub 2013 May 16 doi: 10.1016/j.rbmo.2013.05.004. PMID: 23797052
Petersen CG, Massaro FC, Mauri AL, Oliveira JB, Baruffi RL, Franco JG Jr
Reprod Biol Endocrinol 2010 Dec 3;8:149. doi: 10.1186/1477-7827-8-149. PMID: 21129168Free PMC Article
Bellastella G, Cooper TG, Battaglia M, Ströse A, Torres I, Hellenkemper B, Soler C, Sinisi AA
Asian J Androl 2010 Nov;12(6):871-9. Epub 2010 Sep 20 doi: 10.1038/aja.2010.90. PMID: 20852650Free PMC Article

Diagnosis

Oud MS, Okutman Ö, Hendricks LAJ, de Vries PF, Houston BJ, Vissers LELM, O'Bryan MK, Ramos L, Chemes HE, Viville S, Veltman JA
Hum Reprod 2020 Jan 1;35(1):240-252. doi: 10.1093/humrep/dez246. PMID: 31985809Free PMC Article
Nobles CJ, Schisterman EF, Ha S, Kim K, Mumford SL, Buck Louis GM, Chen Z, Liu D, Sherman S, Mendola P
Environ Res 2018 May;163:228-236. Epub 2018 Feb 22 doi: 10.1016/j.envres.2018.02.004. PMID: 29459305Free PMC Article

Therapy

Nobles CJ, Schisterman EF, Ha S, Kim K, Mumford SL, Buck Louis GM, Chen Z, Liu D, Sherman S, Mendola P
Environ Res 2018 May;163:228-236. Epub 2018 Feb 22 doi: 10.1016/j.envres.2018.02.004. PMID: 29459305Free PMC Article

Prognosis

Oud MS, Okutman Ö, Hendricks LAJ, de Vries PF, Houston BJ, Vissers LELM, O'Bryan MK, Ramos L, Chemes HE, Viville S, Veltman JA
Hum Reprod 2020 Jan 1;35(1):240-252. doi: 10.1093/humrep/dez246. PMID: 31985809Free PMC Article

Clinical prediction guides

Xu YH, Lu JC, Tang SS
J Clin Lab Anal 2022 Dec;36(12):e24794. Epub 2022 Nov 28 doi: 10.1002/jcla.24794. PMID: 36441612Free PMC Article
Oud MS, Okutman Ö, Hendricks LAJ, de Vries PF, Houston BJ, Vissers LELM, O'Bryan MK, Ramos L, Chemes HE, Viville S, Veltman JA
Hum Reprod 2020 Jan 1;35(1):240-252. doi: 10.1093/humrep/dez246. PMID: 31985809Free PMC Article
Nobles CJ, Schisterman EF, Ha S, Kim K, Mumford SL, Buck Louis GM, Chen Z, Liu D, Sherman S, Mendola P
Environ Res 2018 May;163:228-236. Epub 2018 Feb 22 doi: 10.1016/j.envres.2018.02.004. PMID: 29459305Free PMC Article
Perdrix A, Travers A, Chelli MH, Escalier D, Do Rego JL, Milazzo JP, Mousset-Siméon N, Macé B, Rives N
Hum Reprod 2011 Jan;26(1):47-58. Epub 2010 Nov 18 doi: 10.1093/humrep/deq297. PMID: 21088015
Wood S, Aziz N, Millar A, Schnauffer K, Meacock S, El Ghobashy A, Lewis-Jones I
Andrologia 2003 Dec;35(6):358-67. doi: 10.1046/j.0303-4569.2003.00591.x. PMID: 15018138

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