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Sertoli cell hyperplasia

MedGen UID:
1841853
•Concept ID:
C5826635
•
Finding
HPO: HP:0034746

Definition

Abnormal increase in the number of Sertoli cells in the testis. [from HPO]

Professional guidelines

PubMed

Characterization and management of testicular pathology in McCune-Albright syndrome.
Boyce AM, Chong WH, Shawker TH, Pinto PA, Linehan WM, Bhattacharryya N, Merino MJ, Singer FR, Collins MT
J Clin Endocrinol Metab 2012 Sep;97(9):E1782-90. Epub 2012 Jun 28 doi: 10.1210/jc.2012-1791. PMID: 22745241Free PMC Article

Recent clinical studies

Etiology

Risk of Malignancy and Need for Surgery in Pediatric Patients with Morris or Y-chromosome Turner Syndrome: A Multicenter Survey.
Esposito C, Escolino M, Bagnara V, Eckoldt-Wolke F, Baglaj M, Saxena A, Patkowski D, Schier F, Settimi A, Martelli H, Savanelli A
J Pediatr Adolesc Gynecol 2015 Oct;28(5):333-6. Epub 2014 Oct 5 doi: 10.1016/j.jpag.2014.09.015. PMID: 26148783
Characterization and management of testicular pathology in McCune-Albright syndrome.
Boyce AM, Chong WH, Shawker TH, Pinto PA, Linehan WM, Bhattacharryya N, Merino MJ, Singer FR, Collins MT
J Clin Endocrinol Metab 2012 Sep;97(9):E1782-90. Epub 2012 Jun 28 doi: 10.1210/jc.2012-1791. PMID: 22745241Free PMC Article
Quantitative and ultrastructural alterations in the lamina propria and Sertoli cells in human cryptorchid testes.
Paniagua R, Martinez-Onsurbe P, Santamaria L, Saez FJ, Amat P, Nistal M
Int J Androl 1990 Dec;13(6):470-87. doi: 10.1111/j.1365-2605.1990.tb01054.x. PMID: 1982882
Histologic classification of undescended testes.
Nistal M, Paniagua R, Díez-Pardo JA
Hum Pathol 1980 Nov;11(6):666-74. doi: 10.1016/s0046-8177(80)80078-5. PMID: 6108912

Diagnosis

Risk of Malignancy and Need for Surgery in Pediatric Patients with Morris or Y-chromosome Turner Syndrome: A Multicenter Survey.
Esposito C, Escolino M, Bagnara V, Eckoldt-Wolke F, Baglaj M, Saxena A, Patkowski D, Schier F, Settimi A, Martelli H, Savanelli A
J Pediatr Adolesc Gynecol 2015 Oct;28(5):333-6. Epub 2014 Oct 5 doi: 10.1016/j.jpag.2014.09.015. PMID: 26148783
Viral-type orchitis: a potential mimic of testicular neoplasia.
Braaten KM, Young RH, Ferry JA
Am J Surg Pathol 2009 Oct;33(10):1477-84. doi: 10.1097/PAS.0b013e3181ac36eb. PMID: 19623033
McCune-Albright syndrome in a boy may present with a monolateral macroorchidism as an early and isolated clinical manifestation.
Arrigo T, Pirazzoli P, De Sanctis L, Leone O, Wasniewska M, Messina MF, De Luca F
Horm Res 2006;65(3):114-9. Epub 2006 Feb 2 doi: 10.1159/000091279. PMID: 16462147
A case of sex reversal syndrome with sex-determining region (XX male).
Yamamoto M, Yokoi K, Katsuno S, Hibi H, Miyake K
Nagoya J Med Sci 1995 Dec;58(3-4):111-5. PMID: 8725494
Anatomical and clinical correlation with histological and histometric patterns in cryptorchism.
Gutierrez A, Campos A, Cañizares FJ, Crespo PV, Sánchez C
Br J Urol 1993 Oct;72(4):506-9. doi: 10.1111/j.1464-410x.1993.tb16187.x. PMID: 7903194

Prognosis

Characterization and management of testicular pathology in McCune-Albright syndrome.
Boyce AM, Chong WH, Shawker TH, Pinto PA, Linehan WM, Bhattacharryya N, Merino MJ, Singer FR, Collins MT
J Clin Endocrinol Metab 2012 Sep;97(9):E1782-90. Epub 2012 Jun 28 doi: 10.1210/jc.2012-1791. PMID: 22745241Free PMC Article

Clinical prediction guides

Characterization and management of testicular pathology in McCune-Albright syndrome.
Boyce AM, Chong WH, Shawker TH, Pinto PA, Linehan WM, Bhattacharryya N, Merino MJ, Singer FR, Collins MT
J Clin Endocrinol Metab 2012 Sep;97(9):E1782-90. Epub 2012 Jun 28 doi: 10.1210/jc.2012-1791. PMID: 22745241Free PMC Article
Macroorchidism due to autonomous hyperfunction of Sertoli cells and G(s)alpha gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy.
Coutant R, Lumbroso S, Rey R, Lahlou N, Venara M, Rouleau S, Sultan C, Limal JM
J Clin Endocrinol Metab 2001 Apr;86(4):1778-81. doi: 10.1210/jcem.86.4.7391. PMID: 11297617
Histologic classification of undescended testes.
Nistal M, Paniagua R, Díez-Pardo JA
Hum Pathol 1980 Nov;11(6):666-74. doi: 10.1016/s0046-8177(80)80078-5. PMID: 6108912

Supplemental Content

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