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Decreased amniotic fluid alpha-fetoprotein concentration

MedGen UID:
1841863
•Concept ID:
C5826750
•
Finding
HPO: HP:0034900

Definition

Concentration of alpha-fetoprotein in the amniotic fluid below lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased amniotic fluid alpha-fetoprotein concentration

Recent clinical studies

Etiology

Relationship between protein concentrations in embryological fluids and maternal serum and yolk sac size during human early pregnancy.
Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA
Hum Reprod 1994 Jan;9(1):161-6. doi: 10.1093/oxfordjournals.humrep.a138308. PMID: 8195341
Decreased alpha-fetoprotein in amniotic fluid and maternal serum in diabetic pregnancy.
Henriques CU, Damm P, Tabor A, Pedersen JF, Mølsted-Pedersen L
Obstet Gynecol 1993 Dec;82(6):960-4. PMID: 7694215
Reduced fetal hepatic alpha-fetoprotein levels in Down's syndrome.
Kronquist KE, Dreazen E, Keener SL, Nicholas TW, Crandall BF
Prenat Diagn 1990 Nov;10(11):739-51. doi: 10.1002/pd.1970101108. PMID: 1704627
Maternal serum alpha-fetoprotein and fetal trisomy-21 in women 35 years and older: implications for alpha-fetoprotein screening programs.
Ashwood ER, Cheng E, Luthy DA
Am J Med Genet 1987 Mar;26(3):531-9. doi: 10.1002/ajmg.1320260304. PMID: 2436476
Diagnostic use of meternal serum alpha-fetoprotein levels.
Cowchock FS, Jackson LG
Obstet Gynecol 1976 Jan;47(1):63-8. PMID: 54892

Diagnosis

Decreased alpha-fetoprotein in amniotic fluid and maternal serum in diabetic pregnancy.
Henriques CU, Damm P, Tabor A, Pedersen JF, Mølsted-Pedersen L
Obstet Gynecol 1993 Dec;82(6):960-4. PMID: 7694215
Decreased levels of amniotic fluid alpha-fetoprotein associated with Down syndrome.
Davis RO, Cosper P, Huddleston JF, Bradley EL, Finley SC, Finley WH, Milunsky A
Am J Obstet Gynecol 1985 Nov 1;153(5):541-4. doi: 10.1016/0002-9378(85)90469-7. PMID: 2414991
Alpha-fetoprotein and beta-human chorionic gonadotropin in amniotic fluid.
Klink F, Grosspietzsch R, Conte N, Vallerino G, Diani F
Int J Biol Res Pregnancy 1981;2(2):99-101. PMID: 6174456
Concanavalin A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural tube defects.
Buamah PK, Taylor P, Ward AM
Clin Chem 1981 Oct;27(10):1658-60. PMID: 6169467
Reactivity of amniotic fluid alpha-fetoprotein with concanavalin A in relation to gestational age: clinical implications.
Toftager-Larsen K, Kjaersgaard E, Jacobsen JC, Nørgaard-Pedersen B
Clin Chem 1980 Nov;26(12):1656-9. PMID: 6159124

Therapy

Hydrocephalus and abnormal digits after failed first-trimester prostaglandin abortion attempt.
Collins FS, Mahoney MJ
J Pediatr 1983 Apr;102(4):620-1. doi: 10.1016/s0022-3476(83)80204-2. PMID: 6572713
Diagnostic use of meternal serum alpha-fetoprotein levels.
Cowchock FS, Jackson LG
Obstet Gynecol 1976 Jan;47(1):63-8. PMID: 54892

Prognosis

Prenatal screening for congenital nephrosis in east Finland: results and impact on the birth prevalence of the disease.
Heinonen S, Ryynänen M, Kirkinen P, Penttilä I, Syrjänen K, Seppälä M, Saarikoski S
Prenat Diagn 1996 Mar;16(3):207-13. doi: 10.1002/(SICI)1097-0223(199603)16:3<207::AID-PD834>3.0.CO;2-K. PMID: 8710773
Amniotic fluid analysis in prenatal diagnosis of neural tube defects: a comparison between six biochemical tests supplementary to the measurement of amniotic fluid alpha-fetoprotein.
Toftager-Larsen K, Wandrup J, Nørgaard-Pedersen B
Clin Genet 1984 Nov;26(5):406-13. doi: 10.1111/j.1399-0004.1984.tb01080.x. PMID: 6209039
Diagnostic use of meternal serum alpha-fetoprotein levels.
Cowchock FS, Jackson LG
Obstet Gynecol 1976 Jan;47(1):63-8. PMID: 54892

Clinical prediction guides

Prenatal screening for congenital nephrosis in east Finland: results and impact on the birth prevalence of the disease.
Heinonen S, Ryynänen M, Kirkinen P, Penttilä I, Syrjänen K, Seppälä M, Saarikoski S
Prenat Diagn 1996 Mar;16(3):207-13. doi: 10.1002/(SICI)1097-0223(199603)16:3<207::AID-PD834>3.0.CO;2-K. PMID: 8710773
Decreased alpha-fetoprotein in amniotic fluid and maternal serum in diabetic pregnancy.
Henriques CU, Damm P, Tabor A, Pedersen JF, Mølsted-Pedersen L
Obstet Gynecol 1993 Dec;82(6):960-4. PMID: 7694215
Reduced fetal hepatic alpha-fetoprotein levels in Down's syndrome.
Kronquist KE, Dreazen E, Keener SL, Nicholas TW, Crandall BF
Prenat Diagn 1990 Nov;10(11):739-51. doi: 10.1002/pd.1970101108. PMID: 1704627
Amniotic fluid analysis in prenatal diagnosis of neural tube defects: a comparison between six biochemical tests supplementary to the measurement of amniotic fluid alpha-fetoprotein.
Toftager-Larsen K, Wandrup J, Nørgaard-Pedersen B
Clin Genet 1984 Nov;26(5):406-13. doi: 10.1111/j.1399-0004.1984.tb01080.x. PMID: 6209039
Alpha-fetoprotein and beta-human chorionic gonadotropin in amniotic fluid.
Klink F, Grosspietzsch R, Conte N, Vallerino G, Diani F
Int J Biol Res Pregnancy 1981;2(2):99-101. PMID: 6174456

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