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Excess residual spermatozoal cytoplasm

MedGen UID:
Concept ID:
HPO: HP:0034795


Excess residual cytoplasm is associated with abnormal spermatozoa produced from a defective spermiation process. This abnormal excess cytoplasm should not be confused with more physiological cytoplasmic residues that can be observed in direct microscopy of the ejaculate but not in dried, fixed and stained morphology smears. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExcess residual spermatozoal cytoplasm

Conditions with this feature

Spermatogenic failure, X-linked, 7
MedGen UID:
Concept ID:
Disease or Syndrome
X-linked spermatogenic failure-7 (SPGFX7) is characterized by male infertility due to significantly reduced sperm concentration and progressive motility, with abnormalities of the head and flagella. Patient sperm show insufficient individualization, excessive residual cytoplasm, and defects in acrosome development (Zhang et al., 2023). For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).

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