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Reduced bone-marrow megakaryocyte size

MedGen UID:
1842055
•Concept ID:
C5826464
•
Finding
HPO: HP:0034541

Definition

Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced bone-marrow megakaryocyte size

Professional guidelines

PubMed

Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment.
Smetana K, Hrkal Z
Eur J Histochem 2003;47(1):39-43. doi: 10.4081/805. PMID: 12685556
Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study.
Pathansali R, Smith NM, Bath PM
Platelets 2001 May;12(3):144-9. doi: 10.1080/09537100120039000. PMID: 11304415

Recent clinical studies

Etiology

Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thromb Res 2018 Nov;171:45-54. Epub 2018 Sep 20 doi: 10.1016/j.thromres.2018.09.053. PMID: 30248660
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S
J Thromb Haemost 2015 Jul;13(7):1285-92. Epub 2015 May 25 doi: 10.1111/jth.12966. PMID: 25876182
Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells.
Fuhler GM, Tyl MR, Olthof SG, Lyndsay Drayer A, Blom N, Vellenga E
Eur J Haematol 2009 Sep;83(3):235-45. Epub 2009 Apr 1 doi: 10.1111/j.1600-0609.2009.01263.x. PMID: 19341427
The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
Sacchi S
Leuk Lymphoma 1995 Sep;19(1-2):13-20. doi: 10.3109/10428199509059658. PMID: 8574158
Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.
Wadenvik H, Braide I, Ridell B, Kutti J, Jacobsson S, Revesz P
Leuk Res 1994 Aug;18(8):569-75. doi: 10.1016/0145-2126(94)90038-8. PMID: 8065159

Diagnosis

Osteolytic Lesions in Primary Myelofibrosis and Effect of Ruxolitinib Therapy: Report of a Case and Literature Review.
Bucelli C, Cattaneo D, Valli VB, Levati GV, Lonati S, Gianelli U, Iurlo A
Chemotherapy 2018;63(6):340-344. Epub 2019 Apr 9 doi: 10.1159/000497246. PMID: 30965327
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thromb Res 2018 Nov;171:45-54. Epub 2018 Sep 20 doi: 10.1016/j.thromres.2018.09.053. PMID: 30248660
Developmental differences between newborn and adult mice in response to romiplostim.
Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC
Platelets 2018 Jun;29(4):365-372. Epub 2017 May 26 doi: 10.1080/09537104.2017.1316481. PMID: 28548028Free PMC Article
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S
J Thromb Haemost 2015 Jul;13(7):1285-92. Epub 2015 May 25 doi: 10.1111/jth.12966. PMID: 25876182
Immature human megakaryocytes produce nuclear-associated acetylcholinesterase.
Lev-Lehman E, Deutsch V, Eldor A, Soreq H
Blood 1997 May 15;89(10):3644-53. PMID: 9160669

Therapy

Developmental differences between newborn and adult mice in response to romiplostim.
Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC
Platelets 2018 Jun;29(4):365-372. Epub 2017 May 26 doi: 10.1080/09537104.2017.1316481. PMID: 28548028Free PMC Article
Megakaryocyte features and bcr/abl translocation in chronic myeloid leukemia following imatinib mesylate (STI571) therapy--a fluorescence in-situ hybridization study.
Thiele J, Kvasnicka HM, Varus E, Ollig E, Schmitt-Graeff A, Staib P, Griesshammer M
Leuk Lymphoma 2004 Aug;45(8):1627-31. doi: 10.1080/10428190410001683732. PMID: 15370216
Relation of platelet abnormalities to thrombosis and hemorrhage in chronic myeloproliferative disorders.
Wehmeier A, Südhoff T, Meierkord F
Semin Thromb Hemost 1997;23(4):391-402. doi: 10.1055/s-2007-996114. PMID: 9263357
The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
Sacchi S
Leuk Lymphoma 1995 Sep;19(1-2):13-20. doi: 10.3109/10428199509059658. PMID: 8574158
Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.
Wadenvik H, Braide I, Ridell B, Kutti J, Jacobsson S, Revesz P
Leuk Res 1994 Aug;18(8):569-75. doi: 10.1016/0145-2126(94)90038-8. PMID: 8065159

Prognosis

A case of pure red cell aplasia during nivolumab therapy for cardiac metastatic melanoma.
Yuki A, Takenouchi T, Takatsuka S, Ishiguro T
Melanoma Res 2017 Dec;27(6):635-637. doi: 10.1097/CMR.0000000000000392. PMID: 28872489
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S
J Thromb Haemost 2015 Jul;13(7):1285-92. Epub 2015 May 25 doi: 10.1111/jth.12966. PMID: 25876182
Role of immunocompetent cells in the regulation of human megakaryocytopoiesis in vitro.
Detrick RA, Schulman JC, Mamus SW, McEver RP, Zanjani ED
Adv Exp Med Biol 1988;241:199-215. doi: 10.1007/978-1-4684-5571-7_23. PMID: 3146906

Clinical prediction guides

Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thromb Res 2018 Nov;171:45-54. Epub 2018 Sep 20 doi: 10.1016/j.thromres.2018.09.053. PMID: 30248660
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S
J Thromb Haemost 2015 Jul;13(7):1285-92. Epub 2015 May 25 doi: 10.1111/jth.12966. PMID: 25876182
The role of alpha-interferon in essential thrombocythaemia, polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM): a concise update.
Sacchi S
Leuk Lymphoma 1995 Sep;19(1-2):13-20. doi: 10.3109/10428199509059658. PMID: 8574158
Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.
Wadenvik H, Braide I, Ridell B, Kutti J, Jacobsson S, Revesz P
Leuk Res 1994 Aug;18(8):569-75. doi: 10.1016/0145-2126(94)90038-8. PMID: 8065159
The control of megakaryocyte ploidy and platelet production: biology and pathology.
Gladwin AM, Martin JF
Int J Cell Cloning 1990 Jul;8(4):291-8. doi: 10.1002/stem.5530080414. PMID: 2205666

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