U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated erythrocyte adenosine triphosphate concentration

MedGen UID:
1842068
•Concept ID:
C5826912
•
Finding
Synonym: Adenosine triphosphate (ATP) high in erythrocytes
 
HPO: HP:4000186

Definition

Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated erythrocyte adenosine triphosphate concentration

Professional guidelines

PubMed

Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.
Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M
Traffic 2004 Jul;5(7):478-92. doi: 10.1111/j.1398-9219.2004.00193.x. PMID: 15180825Free PMC Article

Recent clinical studies

Etiology

An In Vitro Comparative Study of the Effects of Tetrabromobisphenol A and Tetrabromobisphenol S on Human Erythrocyte Membranes-Changes in ATP Level, Perturbations in Membrane Fluidity, Alterations in Conformational State and Damage to Proteins.
Jarosiewicz M, Duchnowicz P, Jarosiewicz P, Huras B, Bukowska B
Int J Mol Sci 2021 Aug 31;22(17) doi: 10.3390/ijms22179443. PMID: 34502352Free PMC Article
Antioxidant status and energy state of erythrocytes in Alzheimer dementia: probing for markers.
Kosenko EA, Aliev G, Tikhonova LA, Li Y, Poghosyan AC, Kaminsky YG
CNS Neurol Disord Drug Targets 2012 Nov 1;11(7):926-32. doi: 10.2174/1871527311201070926. PMID: 22998137
Cellular toxicity of nicotinamide metabolites.
Rutkowski B, Rutkowski P, Słomińska E, Smolenski RT, Swierczyński J
J Ren Nutr 2012 Jan;22(1):95-7. doi: 10.1053/j.jrn.2011.10.033. PMID: 22200423
High plasma adenine concentration in chronic renal failure and its relation to erythrocyte ATP.
Slominska EM, Szolkiewicz M, Smolenski RT, Rutkowski B, Swierczynski J
Nephron 2002 Jun;91(2):286-91. doi: 10.1159/000058406. PMID: 12053067
Changes in Na,K-adenosine triphosphatase (ATPase) concentration and Na,K-ATPase-dependent adenosine triphosphate turnover in human erythrocytes in diabetes.
Garner MH
Metabolism 1996 Aug;45(8):927-34. doi: 10.1016/s0026-0495(96)90257-7. PMID: 8769346

Diagnosis

A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.
Bax BE, Bain MD, Fairbanks LD, Webster AD, Ind PW, Hershfield MS, Chalmers RA
Eur J Haematol 2007 Oct;79(4):338-48. Epub 2007 Aug 3 doi: 10.1111/j.1600-0609.2007.00927.x. PMID: 17680812
Postoperative blood salvage and reinfusion in spinal surgery: blood quality, effectiveness and impact on patient blood parameters.
Sebastián C, Romero R, Olalla E, Ferrer C, García-Vallejo JJ, Muñoz M
Eur Spine J 2000 Dec;9(6):458-65. doi: 10.1007/s005860000167. PMID: 11189913Free PMC Article
Hereditary spherocytosis and elliptocytosis erythrocytes show a normal transbilayer phospholipid distribution.
de Jong K, Larkin SK, Eber S, Franck PF, Roelofsen B, Kuypers FA
Blood 1999 Jul 1;94(1):319-25. PMID: 10381528
Na+ + K+ + 2Cl- cotransport in animal cells--its role in volume regulation.
Geck P, Pfeiffer B
Ann N Y Acad Sci 1985;456:166-82. doi: 10.1111/j.1749-6632.1985.tb14862.x. PMID: 2418724
Purine metabolism in adenosine deaminase deficiency.
Mills GC, Schmalstieg FC, Trimmer KB, Goldman AS, Goldblum RM
Proc Natl Acad Sci U S A 1976 Aug;73(8):2867-71. doi: 10.1073/pnas.73.8.2867. PMID: 1066699Free PMC Article

Therapy

Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia.
Nyberg M, Al-Khazraji BK, Mortensen SP, Jackson DN, Ellis CG, Hellsten Y
Am J Physiol Regul Integr Comp Physiol 2013 Aug 1;305(3):R281-90. Epub 2013 Jun 12 doi: 10.1152/ajpregu.00189.2013. PMID: 23761642Free PMC Article
LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells.
Lipka DB, Hoffmann LS, Heidel F, Markova B, Blum MC, Breitenbuecher F, Kasper S, Kindler T, Levine RL, Huber C, Fischer T
Mol Cancer Ther 2008 May;7(5):1176-84. doi: 10.1158/1535-7163.MCT-07-2215. PMID: 18483305
A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.
Bax BE, Bain MD, Fairbanks LD, Webster AD, Ind PW, Hershfield MS, Chalmers RA
Eur J Haematol 2007 Oct;79(4):338-48. Epub 2007 Aug 3 doi: 10.1111/j.1600-0609.2007.00927.x. PMID: 17680812
Effects of oxidative stress on the erythrocyte Na+,K+ ATPase activity in female hyperthyroid patients.
Konukoglu D, Yelke HK, Hatemi H, Sabuncu T
J Toxicol Environ Health A 2001 Jun 22;63(4):289-95. doi: 10.1080/15287390151143677. PMID: 11437061
Postoperative blood salvage and reinfusion in spinal surgery: blood quality, effectiveness and impact on patient blood parameters.
Sebastián C, Romero R, Olalla E, Ferrer C, García-Vallejo JJ, Muñoz M
Eur Spine J 2000 Dec;9(6):458-65. doi: 10.1007/s005860000167. PMID: 11189913Free PMC Article

Prognosis

Erythrocyte pyruvate kinase deficiency. The influence of physiologically important metabolites on the function of normal and defective enzymes.
Lakomek M, Winkler H, Pekrun A, Krüger N, Sander M, Huppke P, Schröter W
Enzyme Protein 1994-1995;48(3):149-63. PMID: 8589802

Clinical prediction guides

Endothelial calcium dynamics elicited by ATP release from red blood cells.
Nayak AK, Das SL, Misbah C
Sci Rep 2024 Jun 12;14(1):13550. doi: 10.1038/s41598-024-63306-2. PMID: 38866785
Induction of eryptosis by cyclosporine.
Niemoeller OM, Akel A, Lang PA, Attanasio P, Kempe DS, Hermle T, Sobiesiak M, Wieder T, Lang F
Naunyn Schmiedebergs Arch Pharmacol 2006 Oct;374(1):41-9. Epub 2006 Sep 22 doi: 10.1007/s00210-006-0099-5. PMID: 17019514
High plasma adenine concentration in chronic renal failure and its relation to erythrocyte ATP.
Slominska EM, Szolkiewicz M, Smolenski RT, Rutkowski B, Swierczynski J
Nephron 2002 Jun;91(2):286-91. doi: 10.1159/000058406. PMID: 12053067
Na+ + K+ + 2Cl- cotransport in animal cells--its role in volume regulation.
Geck P, Pfeiffer B
Ann N Y Acad Sci 1985;456:166-82. doi: 10.1111/j.1749-6632.1985.tb14862.x. PMID: 2418724
Erythrocyte glycolysis in protein-energy malnutrition.
Mandelbaum IM, Mozes N, Fondu P
Clin Chim Acta 1982 Sep 30;124(3):263-75. doi: 10.1016/0009-8981(82)90421-1. PMID: 6290107

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...