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Unilateral hemispheric polymicrogyria

MedGen UID:
1842283
•Concept ID:
C5681804
•
Congenital Abnormality
Synonym: unilateral hemispheric polymicrogyria
 
Monarch Initiative: MONDO:0015099
Orphanet: ORPHA101071

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnilateral hemispheric polymicrogyria

Professional guidelines

PubMed

Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)-related epilepsy and seizure outcome with different treatment options.
Wu P, Liu Q, Liu X, Sun Y, Zhang J, Wang R, Ji T, Wang S, Liu X, Jiang Y, Cai L, Wu Y
Epilepsia Open 2024 Aug;9(4):1480-1492. Epub 2024 Jun 19 doi: 10.1002/epi4.12988. PMID: 38898786Free PMC Article

Recent clinical studies

Etiology

Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)-related epilepsy and seizure outcome with different treatment options.
Wu P, Liu Q, Liu X, Sun Y, Zhang J, Wang R, Ji T, Wang S, Liu X, Jiang Y, Cai L, Wu Y
Epilepsia Open 2024 Aug;9(4):1480-1492. Epub 2024 Jun 19 doi: 10.1002/epi4.12988. PMID: 38898786Free PMC Article
Parasagittal hemispherotomy in hemispheric polymicrogyria with electrical status epilepticus during slow sleep: Indications, results and follow-up.
Fohlen M, Dorfmüller G, Ferrand-Sorbets S, Dorison N, Chipaux M, Taussig D
Seizure 2019 Oct;71:190-200. Epub 2019 Jul 23 doi: 10.1016/j.seizure.2019.07.017. PMID: 31386962
Stereoelectroencephalography and surgical outcome in polymicrogyria-related epilepsy: A multicentric study.
Maillard LG, Tassi L, Bartolomei F, Catenoix H, Dubeau F, Szurhaj W, Kahane P, Nica A, Marusic P, Mindruta I, Chassoux F, Ramantani G
Ann Neurol 2017 Nov;82(5):781-794. Epub 2017 Nov 11 doi: 10.1002/ana.25081. PMID: 29059488
Megalencephaly and hemimegalencephaly: breakthroughs in molecular etiology.
Mirzaa GM, Poduri A
Am J Med Genet C Semin Med Genet 2014 Jun;166C(2):156-72. Epub 2014 May 28 doi: 10.1002/ajmg.c.31401. PMID: 24888963
Magnetic resonance imaging in developmental disorders of the cerebral cortex.
Kuzniecky RI
Epilepsia 1994;35 Suppl 6:S44-56. doi: 10.1111/j.1528-1157.1994.tb05988.x. PMID: 8206014

Diagnosis

Parasagittal hemispherotomy in hemispheric polymicrogyria with electrical status epilepticus during slow sleep: Indications, results and follow-up.
Fohlen M, Dorfmüller G, Ferrand-Sorbets S, Dorison N, Chipaux M, Taussig D
Seizure 2019 Oct;71:190-200. Epub 2019 Jul 23 doi: 10.1016/j.seizure.2019.07.017. PMID: 31386962
Epilepsy surgery for polymicrogyria: a challenge to be undertaken.
Maillard L, Ramantani G
Epileptic Disord 2018 Oct 1;20(5):319-338. doi: 10.1684/epd.2018.1004. PMID: 30378553
Polymicrogyria-associated epilepsy: a multicenter phenotypic study from the Epilepsy Phenome/Genome Project.
Shain C, Ramgopal S, Fallil Z, Parulkar I, Alongi R, Knowlton R, Poduri A; EPGP Investigators
Epilepsia 2013 Aug;54(8):1368-75. Epub 2013 Jun 10 doi: 10.1111/epi.12238. PMID: 23750890Free PMC Article
Polymicrogyria in chromosome 22q11 deletion syndrome.
Ghariani S, Dahan K, Saint-Martin C, Kadhim H, Morsomme F, Moniotte S, Verellen-Dumoulin C, Sébire G
Eur J Paediatr Neurol 2002;6(1):73-7. doi: 10.1053/ejpn.2001.0544. PMID: 11993959
Magnetic resonance imaging in developmental disorders of the cerebral cortex.
Kuzniecky RI
Epilepsia 1994;35 Suppl 6:S44-56. doi: 10.1111/j.1528-1157.1994.tb05988.x. PMID: 8206014

Therapy

Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)-related epilepsy and seizure outcome with different treatment options.
Wu P, Liu Q, Liu X, Sun Y, Zhang J, Wang R, Ji T, Wang S, Liu X, Jiang Y, Cai L, Wu Y
Epilepsia Open 2024 Aug;9(4):1480-1492. Epub 2024 Jun 19 doi: 10.1002/epi4.12988. PMID: 38898786Free PMC Article
Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms.
Ramachandrannair R, Ochi A, Imai K, Benifla M, Akiyama T, Holowka S, Rutka JT, Snead OC 3rd, Otsubo H
Epilepsy Res 2008 Feb;78(2-3):216-24. Epub 2008 Jan 22 doi: 10.1016/j.eplepsyres.2007.12.007. PMID: 18215506
Source analysis of interictal spikes in polymicrogyria: loss of relevant cortical fissures requires simultaneous EEG to avoid MEG misinterpretation.
Bast T, Ramantani G, Boppel T, Metzke T, Ozkan O, Stippich C, Seitz A, Rupp A, Rating D, Scherg M
Neuroimage 2005 May 1;25(4):1232-41. doi: 10.1016/j.neuroimage.2004.12.059. PMID: 15850741
Infantile spasms with predominantly unilateral cerebral abnormalities.
Miyazaki M, Hashimoto T, Omura H, Satomura S, Bando N, Yoshimoto T, Tayama M, Kuroda Y
Neuropediatrics 1994 Dec;25(6):325-30. doi: 10.1055/s-2008-1073048. PMID: 7770131

Prognosis

Parasagittal hemispherotomy in hemispheric polymicrogyria with electrical status epilepticus during slow sleep: Indications, results and follow-up.
Fohlen M, Dorfmüller G, Ferrand-Sorbets S, Dorison N, Chipaux M, Taussig D
Seizure 2019 Oct;71:190-200. Epub 2019 Jul 23 doi: 10.1016/j.seizure.2019.07.017. PMID: 31386962
Stereoelectroencephalography and surgical outcome in polymicrogyria-related epilepsy: A multicentric study.
Maillard LG, Tassi L, Bartolomei F, Catenoix H, Dubeau F, Szurhaj W, Kahane P, Nica A, Marusic P, Mindruta I, Chassoux F, Ramantani G
Ann Neurol 2017 Nov;82(5):781-794. Epub 2017 Nov 11 doi: 10.1002/ana.25081. PMID: 29059488
Hemispheric polymicrogyria and neonatal seizures: a potentially life-threatening combination.
Brna PM, Harvey AS, Leventer RJ
Epileptic Disord 2017 Mar 1;19(1):87-93. doi: 10.1684/epd.2017.0894. PMID: 28300030
Unilateral holohemispheric central nervous system lesions associated with medically refractory epilepsy in the pediatric population: a retrospective series of hemimegalencephaly and Rasmussen's encephalitis.
Wang DD, Benkli B, Auguste KI, Garcia PA, Sullivan J, Barkovich AJ, Chang EF, Tihan T
J Neurosurg Pediatr 2014 Dec;14(6):573-84. Epub 2014 Oct 10 doi: 10.3171/2014.8.PEDS13613. PMID: 25303156

Clinical prediction guides

Parasagittal hemispherotomy in hemispheric polymicrogyria with electrical status epilepticus during slow sleep: Indications, results and follow-up.
Fohlen M, Dorfmüller G, Ferrand-Sorbets S, Dorison N, Chipaux M, Taussig D
Seizure 2019 Oct;71:190-200. Epub 2019 Jul 23 doi: 10.1016/j.seizure.2019.07.017. PMID: 31386962
Stereoelectroencephalography and surgical outcome in polymicrogyria-related epilepsy: A multicentric study.
Maillard LG, Tassi L, Bartolomei F, Catenoix H, Dubeau F, Szurhaj W, Kahane P, Nica A, Marusic P, Mindruta I, Chassoux F, Ramantani G
Ann Neurol 2017 Nov;82(5):781-794. Epub 2017 Nov 11 doi: 10.1002/ana.25081. PMID: 29059488
Epilepsy surgery in Neurofibromatosis Type 1.
Barba C, Jacques T, Kahane P, Polster T, Isnard J, Leijten FS, Ozkara C, Tassi L, Giordano F, Castagna M, John A, Oz B, Salon C, Streichenberger N, Cross JH, Guerrini R
Epilepsy Res 2013 Aug;105(3):384-95. Epub 2013 Apr 16 doi: 10.1016/j.eplepsyres.2013.02.021. PMID: 23597854
Polymicrogyria in chromosome 22q11 deletion syndrome.
Ghariani S, Dahan K, Saint-Martin C, Kadhim H, Morsomme F, Moniotte S, Verellen-Dumoulin C, Sébire G
Eur J Paediatr Neurol 2002;6(1):73-7. doi: 10.1053/ejpn.2001.0544. PMID: 11993959
Unilateral polymicrogyria: a common cause of hemiplegia of prenatal origin.
Pascual-Castroviejo I, Pascual-Pascual SI, Viaño J, Martinez V, Palencia R
Brain Dev 2001 Jul;23(4):216-22. doi: 10.1016/s0387-7604(01)00211-x. PMID: 11376999

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