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Neuromyelitis optica spectrum disorder without anti-MOG and without anti-AQP4 antibodies

MedGen UID:
1842615
•Concept ID:
C5680297
•
Disease or Syndrome
Synonyms: neuromyelitis optica spectrum disorder without anti-MOG and without anti-AQP4 antibodies; Neuromyelitis optica spectrum disorder without anti-Myelin oligodendrocyte glycoprotein and without anti-Aquaporin-4 antibodies; NMOSD without anti-MOG antibodies and without anti-AQP4 antibodies
 
Monarch Initiative: MONDO:0035665
Orphanet: ORPHA592869

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuromyelitis optica spectrum disorder without anti-MOG and without anti-AQP4 antibodies

Professional guidelines

PubMed

Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Demuth S, Guillaume M, Bourre B, Ciron J, Zephir H, Sirejacob Y, Kerbrat A, Lebrun-Frenay C, Papeix C, Michel L, Laplaud D, Vukusic S, Maillart E, Cohen M, Audoin B, Marignier R, Collongues N; NOMADMUS Study Group
J Neuroinflammation 2022 Mar 2;19(1):62. doi: 10.1186/s12974-022-02420-2. PMID: 35236386Free PMC Article
Neuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models.
Wu Y, Zhong L, Geng J
Mult Scler Relat Disord 2019 Jan;27:412-418. Epub 2018 Dec 3 doi: 10.1016/j.msard.2018.12.002. PMID: 30530071
Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment?
Derfuss T, Meinl E
Curr Opin Neurol 2012 Jun;25(3):231-8. doi: 10.1097/WCO.0b013e3283533a64. PMID: 22487571

Recent clinical studies

Etiology

Polyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
Lopes J, Fonte J, Costa A, Martins DA, Samões R, Sousa AP, Carneiro P, Farinha F, Santos E, Silva AM
Mult Scler Relat Disord 2024 Oct;90:105848. Epub 2024 Aug 24 doi: 10.1016/j.msard.2024.105848. PMID: 39236487
Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
Yılmaz Ü, Gücüyener K, Yavuz M, Öncel İ, Canpolat M, Saltık S, Ünver O, Çıtak Kurt AN, Tosun A, Yılmaz S, Özgör B, Erol İ, Öztoprak Ü, Elitez DA, Direk MÇ, Bodur M, Teber S, Anlar B; Turkish Pediatric Multiple Sclerosis Study Group
Eur J Paediatr Neurol 2022 Nov;41:8-18. Epub 2022 Sep 1 doi: 10.1016/j.ejpn.2022.08.006. PMID: 36137476
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Demuth S, Guillaume M, Bourre B, Ciron J, Zephir H, Sirejacob Y, Kerbrat A, Lebrun-Frenay C, Papeix C, Michel L, Laplaud D, Vukusic S, Maillart E, Cohen M, Audoin B, Marignier R, Collongues N; NOMADMUS Study Group
J Neuroinflammation 2022 Mar 2;19(1):62. doi: 10.1186/s12974-022-02420-2. PMID: 35236386Free PMC Article
Pediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Martins C, Moura J, Figueiroa S, Garrido C, Martins J, Samões R, Guimarães J, Melo C, Sousa R, Palavra F, Ferreira J, da Silva AM, Sá MJ, Santos E
Mult Scler Relat Disord 2022 Mar;59:103531. Epub 2022 Jan 19 doi: 10.1016/j.msard.2022.103531. PMID: 35078127
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560

Diagnosis

Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
Yılmaz Ü, Gücüyener K, Yavuz M, Öncel İ, Canpolat M, Saltık S, Ünver O, Çıtak Kurt AN, Tosun A, Yılmaz S, Özgör B, Erol İ, Öztoprak Ü, Elitez DA, Direk MÇ, Bodur M, Teber S, Anlar B; Turkish Pediatric Multiple Sclerosis Study Group
Eur J Paediatr Neurol 2022 Nov;41:8-18. Epub 2022 Sep 1 doi: 10.1016/j.ejpn.2022.08.006. PMID: 36137476
Pediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Martins C, Moura J, Figueiroa S, Garrido C, Martins J, Samões R, Guimarães J, Melo C, Sousa R, Palavra F, Ferreira J, da Silva AM, Sá MJ, Santos E
Mult Scler Relat Disord 2022 Mar;59:103531. Epub 2022 Jan 19 doi: 10.1016/j.msard.2022.103531. PMID: 35078127
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560
Clinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Fragoso YD, Sousa NAC, Alves-Leon SV, Dias RM, Pimentel MLV, Gomes S, Goncalves MVM, Stella CV, Tauil CB, Anacleto A, Spessotto CV, Correa EC, Eboni ACB, Damasceno A, Damasceno B, Farinhas JGD, Mota RSS, Nogueira EGA, Pereira VCSR, Scorcine C, Bacon T, Kister I
Mult Scler Relat Disord 2019 Jan;27:392-396. Epub 2018 Nov 28 doi: 10.1016/j.msard.2018.11.031. PMID: 30504040
Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment?
Derfuss T, Meinl E
Curr Opin Neurol 2012 Jun;25(3):231-8. doi: 10.1097/WCO.0b013e3283533a64. PMID: 22487571

Therapy

The efficacy of rituximab in patients with neuromyelitis optica spectrum disorder: A real-world study from Turkey.
Uzunköprü C, Tütüncü M, Gündüz T, Gümüş H, Şen S, Demir S, Çınar BP, Türe HS, Uygunoğlu U, Toğrol RE, Terzi M, Kürtüncü M, Özakbaş S, Tütüncü M, Beckmann Y, Siva A
Int J Clin Pract 2021 Jul;75(7):e14158. Epub 2021 Apr 8 doi: 10.1111/ijcp.14158. PMID: 33743552
Optic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study.
Haddad N, Roussel B, Pelcovits A, Rizvi S
Mult Scler Relat Disord 2019 Sep;34:14-16. Epub 2019 Jun 14 doi: 10.1016/j.msard.2019.06.010. PMID: 31226544
Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study.
Kovacs KT, Kalluri SR, Boza-Serrano A, Deierborg T, Csepany T, Simo M, Rokusz L, Miseta A, Alcaraz N, Czirjak L, Berki T, Molnar T, Hemmer B, Illes Z
Mult Scler 2016 Aug;22(9):1192-201. Epub 2015 Oct 29 doi: 10.1177/1352458515613165. PMID: 26514978
Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis.
Titulaer MJ, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson LA, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales PS, Wirtz PW, Yamamoto T, Reindl M, Rosenfeld MR, Graus F, Saiz A, Dalmau J
Ann Neurol 2014 Mar;75(3):411-28. doi: 10.1002/ana.24117. PMID: 24700511Free PMC Article
Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta.
Xu Y, Zhang Y, Ye J, Peng B, Wang JM, Cui LY
Neurol Sci 2012 Aug;33(4):911-3. Epub 2011 Nov 27 doi: 10.1007/s10072-011-0849-0. PMID: 22120187

Prognosis

Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD.
Akaishi T, Himori N, Takeshita T, Misu T, Takahashi T, Takai Y, Nishiyama S, Kaneko K, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakazawa T, Nakashima I
J Neurol Sci 2022 Jun 15;437:120269. Epub 2022 Apr 22 doi: 10.1016/j.jns.2022.120269. PMID: 35483239
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Demuth S, Guillaume M, Bourre B, Ciron J, Zephir H, Sirejacob Y, Kerbrat A, Lebrun-Frenay C, Papeix C, Michel L, Laplaud D, Vukusic S, Maillart E, Cohen M, Audoin B, Marignier R, Collongues N; NOMADMUS Study Group
J Neuroinflammation 2022 Mar 2;19(1):62. doi: 10.1186/s12974-022-02420-2. PMID: 35236386Free PMC Article
Pediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Martins C, Moura J, Figueiroa S, Garrido C, Martins J, Samões R, Guimarães J, Melo C, Sousa R, Palavra F, Ferreira J, da Silva AM, Sá MJ, Santos E
Mult Scler Relat Disord 2022 Mar;59:103531. Epub 2022 Jan 19 doi: 10.1016/j.msard.2022.103531. PMID: 35078127
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560
Clinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Fragoso YD, Sousa NAC, Alves-Leon SV, Dias RM, Pimentel MLV, Gomes S, Goncalves MVM, Stella CV, Tauil CB, Anacleto A, Spessotto CV, Correa EC, Eboni ACB, Damasceno A, Damasceno B, Farinhas JGD, Mota RSS, Nogueira EGA, Pereira VCSR, Scorcine C, Bacon T, Kister I
Mult Scler Relat Disord 2019 Jan;27:392-396. Epub 2018 Nov 28 doi: 10.1016/j.msard.2018.11.031. PMID: 30504040

Clinical prediction guides

Polyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
Lopes J, Fonte J, Costa A, Martins DA, Samões R, Sousa AP, Carneiro P, Farinha F, Santos E, Silva AM
Mult Scler Relat Disord 2024 Oct;90:105848. Epub 2024 Aug 24 doi: 10.1016/j.msard.2024.105848. PMID: 39236487
Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
Yılmaz Ü, Gücüyener K, Yavuz M, Öncel İ, Canpolat M, Saltık S, Ünver O, Çıtak Kurt AN, Tosun A, Yılmaz S, Özgör B, Erol İ, Öztoprak Ü, Elitez DA, Direk MÇ, Bodur M, Teber S, Anlar B; Turkish Pediatric Multiple Sclerosis Study Group
Eur J Paediatr Neurol 2022 Nov;41:8-18. Epub 2022 Sep 1 doi: 10.1016/j.ejpn.2022.08.006. PMID: 36137476
Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD.
Akaishi T, Himori N, Takeshita T, Misu T, Takahashi T, Takai Y, Nishiyama S, Kaneko K, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakazawa T, Nakashima I
J Neurol Sci 2022 Jun 15;437:120269. Epub 2022 Apr 22 doi: 10.1016/j.jns.2022.120269. PMID: 35483239
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Demuth S, Guillaume M, Bourre B, Ciron J, Zephir H, Sirejacob Y, Kerbrat A, Lebrun-Frenay C, Papeix C, Michel L, Laplaud D, Vukusic S, Maillart E, Cohen M, Audoin B, Marignier R, Collongues N; NOMADMUS Study Group
J Neuroinflammation 2022 Mar 2;19(1):62. doi: 10.1186/s12974-022-02420-2. PMID: 35236386Free PMC Article
Clinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Fragoso YD, Sousa NAC, Alves-Leon SV, Dias RM, Pimentel MLV, Gomes S, Goncalves MVM, Stella CV, Tauil CB, Anacleto A, Spessotto CV, Correa EC, Eboni ACB, Damasceno A, Damasceno B, Farinhas JGD, Mota RSS, Nogueira EGA, Pereira VCSR, Scorcine C, Bacon T, Kister I
Mult Scler Relat Disord 2019 Jan;27:392-396. Epub 2018 Nov 28 doi: 10.1016/j.msard.2018.11.031. PMID: 30504040

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