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Autoimmune neurological channelopathy

MedGen UID:: 1843069
•Concept ID:: C5681703
•: Disease or Syndrome

Orphanet:

ORPHA98750

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAutoimmune neurological channelopathy

Autoimmune neurological channelopathy

Recent clinical studies

Etiology

Autoimmune astrocytopathy double negative for AQP4-IgG and GFAP-IgG: Retrospective research of clinical practice, biomarkers, and pathology.

Lin PH, Yao HY, Huang L, Fu CC, Yao XL, Lian C, Zhang SF, Lai WD, Lin GY, Liao S, Yang J, Mao ZF, Liu D, Long BY, Yue JJ, Gao C, Long YM
CNS Neurosci Ther 2024 Sep;30(9):e70042. doi: 10.1111/cns.70042. PMID: 39279053 Free PMC Article

Brain radial enhancement pattern in patients with negative glial fibrillary acidic protein-IgG: A cases series study.

Yue J, Lin P, Lian C, Yao H, Jiang L, Liao S, Xu L, Zhang J, Tan J, Chen Z, Yang J, Gao C, Huang L, Yang X, Long Y
J Neurol Sci 2023 Oct 15;453:120782. Epub 2023 Aug 31 doi: 10.1016/j.jns.2023.120782. PMID: 37683309

Clinical Heterogeneity in Patients with Glutamate Decarboxylase Antibody.

Huang J, Li H, Zhou R, Huang W, Lin W, Chen T, Long Y
Neuroimmunomodulation 2019;26(5):234-238. Epub 2019 Oct 29 doi: 10.1159/000502695. PMID: 31661704

Anti-KIR4.1 Antibodies in Chinese Patients with Central Nervous System Inflammatory Demyelinating Disorders.

Zhong R, Liang J, Tao A, Wu L, Yang X, Xu H, Huang Q, Zhuang S, Long Y, Gao C
Neuroimmunomodulation 2016;23(5-6):295-300. Epub 2017 Apr 8 doi: 10.1159/000452764. PMID: 28391264

Neurological channelopathies.

Graves TD, Hanna MG
Postgrad Med J 2005 Jan;81(951):20-32. doi: 10.1136/pgmj.2004.022012. PMID: 15640425 Free PMC Article

See all (11)

Diagnosis

Neuropathic Pain: Mechanism-Based Therapeutics.

Bannister K, Sachau J, Baron R, Dickenson AH
Annu Rev Pharmacol Toxicol 2020 Jan 6;60:257-274. doi: 10.1146/annurev-pharmtox-010818-021524. PMID: 31914896

Autoimmunity in psychotic disorders. Where we stand, challenges and opportunities.

Mané-Damas M, Hoffmann C, Zong S, Tan A, Molenaar PC, Losen M, Martinez-Martinez P
Autoimmun Rev 2019 Sep;18(9):102348. Epub 2019 Jul 16 doi: 10.1016/j.autrev.2019.102348. PMID: 31323365

Neurology--the next 10 years.

Baron R, Ferriero DM, Frisoni GB, Bettegowda C, Gokaslan ZL, Kessler JA, Vezzani A, Waxman SG, Jarius S, Wildemann B, Weller M
Nat Rev Neurol 2015 Nov;11(11):658-64. Epub 2015 Oct 27 doi: 10.1038/nrneurol.2015.196. PMID: 26503922

The Na(x) Channel: What It Is and What It Does.

Noda M, Hiyama TY
Neuroscientist 2015 Aug;21(4):399-412. Epub 2014 Jun 24 doi: 10.1177/1073858414541009. PMID: 24962095

Ion channel diseases of the central nervous system.

Li M, Lester HA
CNS Drug Rev 2001 Summer;7(2):214-40. doi: 10.1111/j.1527-3458.2001.tb00196.x. PMID: 11474425 Free PMC Article

See all (19)

Therapy

Scorpion Peptides and Ion Channels: An Insightful Review of Mechanisms and Drug Development.

Mendes LC, Viana GMM, Nencioni ALA, Pimenta DC, Beraldo-Neto E
Toxins (Basel) 2023 Mar 24;15(4) doi: 10.3390/toxins15040238. PMID: 37104176 Free PMC Article

Autoimmune inflammatory meningoencephalitis in a patient negative for glial fibrillary acidic protein-specific immunoglobulin G.

Xie L, Liu T, Yao H, Wu L, Qiu W, Chen B, Liu S, Huang Q, Yang H, Xu H, Long Y, Gao C
Mult Scler Relat Disord 2019 Feb;28:167-171. Epub 2018 Dec 29 doi: 10.1016/j.msard.2018.12.037. PMID: 30605794

Clinical-pathologic correlations in voltage-gated Kv1 potassium channel complex-subtyped autoimmune painful polyneuropathy.

Lahoria R, Pittock SJ, Gadoth A, Engelstad JK, Lennon VA, Klein CJ
Muscle Nerve 2017 Apr;55(4):520-525. Epub 2017 Feb 13 doi: 10.1002/mus.25371. PMID: 27511450

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.

Ellwardt E, Zipp F
Exp Neurol 2014 Dec;262 Pt A:8-17. Epub 2014 Feb 14 doi: 10.1016/j.expneurol.2014.02.006. PMID: 24530639

Autoimmune channelopathies: well-established and emerging immunotherapy-responsive diseases of the peripheral and central nervous systems.

Vincent A
J Clin Immunol 2010 May;30 Suppl 1:S97-102. doi: 10.1007/s10875-010-9401-x. PMID: 20387102

See all (5)

Prognosis

Neuropathic Pain: Mechanism-Based Therapeutics.

Bannister K, Sachau J, Baron R, Dickenson AH
Annu Rev Pharmacol Toxicol 2020 Jan 6;60:257-274. doi: 10.1146/annurev-pharmtox-010818-021524. PMID: 31914896

Autoimmune inflammatory meningoencephalitis in a patient negative for glial fibrillary acidic protein-specific immunoglobulin G.

Xie L, Liu T, Yao H, Wu L, Qiu W, Chen B, Liu S, Huang Q, Yang H, Xu H, Long Y, Gao C
Mult Scler Relat Disord 2019 Feb;28:167-171. Epub 2018 Dec 29 doi: 10.1016/j.msard.2018.12.037. PMID: 30605794

Neurology--the next 10 years.

See all (3)

Clinical prediction guides

Autoimmune astrocytopathy double negative for AQP4-IgG and GFAP-IgG: Retrospective research of clinical practice, biomarkers, and pathology.

Neuropathic Pain: Mechanism-Based Therapeutics.

Bannister K, Sachau J, Baron R, Dickenson AH
Annu Rev Pharmacol Toxicol 2020 Jan 6;60:257-274. doi: 10.1146/annurev-pharmtox-010818-021524. PMID: 31914896

Neurology--the next 10 years.

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.

Ellwardt E, Zipp F
Exp Neurol 2014 Dec;262 Pt A:8-17. Epub 2014 Feb 14 doi: 10.1016/j.expneurol.2014.02.006. PMID: 24530639

Acquired neuromyotonia: a new autoantibody-mediated neuronal potassium channelopathy.

Hart IK
Am J Med Sci 2000 Apr;319(4):209-16. doi: 10.1097/00000441-200004000-00003. PMID: 10768605

See all (9)