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Acquired central diabetes insipidus

MedGen UID:
1843437
•Concept ID:
C5680256
•
Disease or Syndrome
Synonyms: acquired CDI; acquired central diabetes insipidus; acquired neurogenic diabetes insipidus
 
Monarch Initiative: MONDO:0019846

Definition

Acquired central diabetes insipidus (acquired CDI) is a subtype of central diabetes insipidus (CDI), characterized by polyuria and polydipsia, due to an idiopathic or secondary decrease in vasopressin (AVP) production. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

New developments and concepts in the diagnosis and management of diabetes insipidus (AVP-deficiency and resistance).
Angelousi A, Alexandraki KI, Mytareli C, Grossman AB, Kaltsas G
J Neuroendocrinol 2023 Jan;35(1):e13233. Epub 2023 Jan 22 doi: 10.1111/jne.13233. PMID: 36683321

Recent clinical studies

Etiology

Desmopressin Dose Requirements in Adults with Congenital and Acquired Central Diabetes Insipidus.
Pedersen AN, Andreassen M, Rasmussen AK, Krogh J
Horm Metab Res 2024 Mar;56(3):206-213. Epub 2023 Oct 25 doi: 10.1055/a-2198-7207. PMID: 37879354
Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability.
Daughters K, Manstead ASR, Rees DA
Endocrine 2017 Jul;57(1):166-174. Epub 2017 Jun 8 doi: 10.1007/s12020-017-1332-3. PMID: 28597171Free PMC Article
Central diabetes insipidus in children with acute brain insult.
Yang YH, Lin JJ, Hsia SH, Wu CT, Wang HS, Hung PC, Chou ML, Hsieh MY, Lin KL
Pediatr Neurol 2011 Dec;45(6):377-80. doi: 10.1016/j.pediatrneurol.2011.09.002. PMID: 22114999
Acquired central diabetes insipidus in children: a 12-year Brisbane experience.
Al-Agha AE, Thomsett MJ, Ratcliffe JF, Cotterill AM, Batch JA
J Paediatr Child Health 2001 Apr;37(2):172-5. doi: 10.1046/j.1440-1754.2001.00640.x. PMID: 11328474
Central diabetes insipidus in children and young adults.
Maghnie M, Cosi G, Genovese E, Manca-Bitti ML, Cohen A, Zecca S, Tinelli C, Gallucci M, Bernasconi S, Boscherini B, Severi F, Aricò M
N Engl J Med 2000 Oct 5;343(14):998-1007. doi: 10.1056/NEJM200010053431403. PMID: 11018166

Diagnosis

Acquired forms of central diabetes insipidus: Mechanisms of disease.
Verbalis JG
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101449. Epub 2020 Jul 10 doi: 10.1016/j.beem.2020.101449. PMID: 32792133
Central diabetes insipidus in children with acute brain insult.
Yang YH, Lin JJ, Hsia SH, Wu CT, Wang HS, Hung PC, Chou ML, Hsieh MY, Lin KL
Pediatr Neurol 2011 Dec;45(6):377-80. doi: 10.1016/j.pediatrneurol.2011.09.002. PMID: 22114999
Diabetes insipidus.
Maghnie M
Horm Res 2003;59 Suppl 1:42-54. doi: 10.1159/000067844. PMID: 12566720
Acquired central diabetes insipidus in children: a 12-year Brisbane experience.
Al-Agha AE, Thomsett MJ, Ratcliffe JF, Cotterill AM, Batch JA
J Paediatr Child Health 2001 Apr;37(2):172-5. doi: 10.1046/j.1440-1754.2001.00640.x. PMID: 11328474
Central diabetes insipidus in children and young adults.
Maghnie M, Cosi G, Genovese E, Manca-Bitti ML, Cohen A, Zecca S, Tinelli C, Gallucci M, Bernasconi S, Boscherini B, Severi F, Aricò M
N Engl J Med 2000 Oct 5;343(14):998-1007. doi: 10.1056/NEJM200010053431403. PMID: 11018166

Therapy

Desmopressin Dose Requirements in Adults with Congenital and Acquired Central Diabetes Insipidus.
Pedersen AN, Andreassen M, Rasmussen AK, Krogh J
Horm Metab Res 2024 Mar;56(3):206-213. Epub 2023 Oct 25 doi: 10.1055/a-2198-7207. PMID: 37879354

Prognosis

Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability.
Daughters K, Manstead ASR, Rees DA
Endocrine 2017 Jul;57(1):166-174. Epub 2017 Jun 8 doi: 10.1007/s12020-017-1332-3. PMID: 28597171Free PMC Article
Central diabetes insipidus in children with acute brain insult.
Yang YH, Lin JJ, Hsia SH, Wu CT, Wang HS, Hung PC, Chou ML, Hsieh MY, Lin KL
Pediatr Neurol 2011 Dec;45(6):377-80. doi: 10.1016/j.pediatrneurol.2011.09.002. PMID: 22114999
Acquired central diabetes insipidus in children: a 12-year Brisbane experience.
Al-Agha AE, Thomsett MJ, Ratcliffe JF, Cotterill AM, Batch JA
J Paediatr Child Health 2001 Apr;37(2):172-5. doi: 10.1046/j.1440-1754.2001.00640.x. PMID: 11328474
Central diabetes insipidus in children and young adults.
Maghnie M, Cosi G, Genovese E, Manca-Bitti ML, Cohen A, Zecca S, Tinelli C, Gallucci M, Bernasconi S, Boscherini B, Severi F, Aricò M
N Engl J Med 2000 Oct 5;343(14):998-1007. doi: 10.1056/NEJM200010053431403. PMID: 11018166

Clinical prediction guides

Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability.
Daughters K, Manstead ASR, Rees DA
Endocrine 2017 Jul;57(1):166-174. Epub 2017 Jun 8 doi: 10.1007/s12020-017-1332-3. PMID: 28597171Free PMC Article
Central diabetes insipidus in children with acute brain insult.
Yang YH, Lin JJ, Hsia SH, Wu CT, Wang HS, Hung PC, Chou ML, Hsieh MY, Lin KL
Pediatr Neurol 2011 Dec;45(6):377-80. doi: 10.1016/j.pediatrneurol.2011.09.002. PMID: 22114999

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