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Intraductal breast neoplasm

MedGen UID:
184927
•Concept ID:
C0948967
•
Neoplastic Process
Synonyms: Breast Intraductal Neoplasm; Intraductal Breast Neoplasm; intraductal breast neoplasm
 
Monarch Initiative: MONDO:0002488

Definition

A benign or malignant epithelial neoplasm that arises anywhere in the ductal system of the breast. This category includes intraductal papilloma, intraductal papillary carcinoma, ductal hyperplasia with or without atypia, and ductal carcinoma in situ. [from NCI]

Professional guidelines

PubMed

Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Management of Ductal Carcinoma In Situ (DCIS) of the Breast: Present Approaches and Future Directions.
Solin LJ
Curr Oncol Rep 2019 Mar 5;21(4):33. doi: 10.1007/s11912-019-0777-3. PMID: 30834994

Recent clinical studies

Etiology

DCIS: Risk Assessment in the Molecular Era.
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
Margins in breast cancer: How much is enough?
Pilewskie M, Morrow M
Cancer 2018 Apr 1;124(7):1335-1341. Epub 2018 Jan 16 doi: 10.1002/cncr.31221. PMID: 29338088Free PMC Article

Diagnosis

Treatment Landscape of Ductal Carcinoma In Situ.
Chelariu-Raicu A, Harbeck N
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S76-S82. doi: 10.21614/chirurgia.116.5.suppl.S76. PMID: 34967314
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Therapy

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement.
Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J, Harris JR
Pract Radiat Oncol 2017 Mar-Apr;7(2):73-79. Epub 2016 Sep 17 doi: 10.1016/j.prro.2016.09.007. PMID: 27866865
Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
Wapnir IL, Dignam JJ, Fisher B, Mamounas EP, Anderson SJ, Julian TB, Land SR, Margolese RG, Swain SM, Costantino JP, Wolmark N
J Natl Cancer Inst 2011 Mar 16;103(6):478-88. Epub 2011 Mar 11 doi: 10.1093/jnci/djr027. PMID: 21398619Free PMC Article

Prognosis

Breast Tangent Beam Energy, Surgical Bed-to-Skin Distance and Local Recurrence After Breast-Conserving Treatment.
Nichol A, Narinesingh D, Wade L, Raman S, Gondara L, Speers C, Tran E, Chan EK, Lohrisch CA, Truong P
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):671-680. Epub 2021 Oct 23 doi: 10.1016/j.ijrobp.2021.10.014. PMID: 34699929
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Clinical decision-making in early breast cancer.
Balch CM, Singletary SE, Bland KI
Ann Surg 1993 Mar;217(3):207-25. PMID: 8383953Free PMC Article
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748

Clinical prediction guides

DCIS: Risk Assessment in the Molecular Era.
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188555. Epub 2021 Apr 29 doi: 10.1016/j.bbcan.2021.188555. PMID: 33933557Free PMC Article
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

Recent systematic reviews

Partial breast irradiation versus whole breast radiotherapy for early breast cancer.
Hickey BE, Lehman M
Cochrane Database Syst Rev 2021 Aug 30;8(8):CD007077. doi: 10.1002/14651858.CD007077.pub4. PMID: 34459500Free PMC Article
Benefits and harms of breast cancer screening with mammography in women aged 40-49 years: A systematic review.
van den Ende C, Oordt-Speets AM, Vroling H, van Agt HME
Int J Cancer 2017 Oct 1;141(7):1295-1306. Epub 2017 Jun 5 doi: 10.1002/ijc.30794. PMID: 28542784
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article
Risk of invasive breast cancer after lobular intra-epithelial neoplasia: review of the literature.
Ansquer Y, Delaney S, Santulli P, Salomon L, Carbonne B, Salmon R
Eur J Surg Oncol 2010 Jul;36(7):604-9. Epub 2010 Jun 11 doi: 10.1016/j.ejso.2010.05.019. PMID: 20541352
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes.
Virnig BA, Tuttle TM, Shamliyan T, Kane RL
J Natl Cancer Inst 2010 Feb 3;102(3):170-8. Epub 2010 Jan 13 doi: 10.1093/jnci/djp482. PMID: 20071685

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