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Decreased circulating complement C4a concentration

MedGen UID:
1853274
•Concept ID:
C5779963
•
Finding
Synonyms: C4a deficiency; Complement component 4A deficiency; Decreased serum complement C4a
 
HPO: HP:0045043

Definition

Concentration of the complement component C4a in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating complement C4a concentration

Recent clinical studies

Etiology

Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model.
Watanabe H, Hayashi J, Ohzeki H, Moro H, Sugawara M, Eguchi S
Ann Thorac Surg 1999 May;67(5):1315-9. doi: 10.1016/s0003-4975(99)00213-1. PMID: 10355404
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury.
Donnelly TJ, Meade P, Jagels M, Cryer HG, Law MM, Hugli TE, Shoemaker WC, Abraham E
Crit Care Med 1994 May;22(5):768-76. doi: 10.1097/00003246-199405000-00010. PMID: 8181284

Diagnosis

Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury.
Donnelly TJ, Meade P, Jagels M, Cryer HG, Law MM, Hugli TE, Shoemaker WC, Abraham E
Crit Care Med 1994 May;22(5):768-76. doi: 10.1097/00003246-199405000-00010. PMID: 8181284

Therapy

Combined IgG2, IgG4 and IgA deficiency: low C1q concentrations and the presence of excess C1r and C1s in an adult patient with recurrent pneumococcal infections.
Prellner K, Braconier JH, Sjöholm AG
Acta Pathol Microbiol Immunol Scand C 1985 Dec;93(6):257-63. doi: 10.1111/j.1699-0463.1985.tb02954.x. PMID: 2424262

Prognosis

Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury.
Donnelly TJ, Meade P, Jagels M, Cryer HG, Law MM, Hugli TE, Shoemaker WC, Abraham E
Crit Care Med 1994 May;22(5):768-76. doi: 10.1097/00003246-199405000-00010. PMID: 8181284

Clinical prediction guides

Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury.
Donnelly TJ, Meade P, Jagels M, Cryer HG, Law MM, Hugli TE, Shoemaker WC, Abraham E
Crit Care Med 1994 May;22(5):768-76. doi: 10.1097/00003246-199405000-00010. PMID: 8181284
Combined IgG2, IgG4 and IgA deficiency: low C1q concentrations and the presence of excess C1r and C1s in an adult patient with recurrent pneumococcal infections.
Prellner K, Braconier JH, Sjöholm AG
Acta Pathol Microbiol Immunol Scand C 1985 Dec;93(6):257-63. doi: 10.1111/j.1699-0463.1985.tb02954.x. PMID: 2424262

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