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Pregnancy Complications, Hematologic

MedGen UID:
18614
•Concept ID:
C0032964
•
Disease or Syndrome
Synonyms: Complication, Hematologic Pregnancy; Complication, Hematological Pregnancy; Complications, Hematologic Pregnancy; Complications, Hematological Pregnancy; Hematologic Pregnancy Complication; Hematologic Pregnancy Complications; Hematological Pregnancy Complication; Hematological Pregnancy Complications; Pregnancies, Hematologic Complications; Pregnancy Complication, Hematologic; Pregnancy Complication, Hematological; Pregnancy Complications, Hematological; Pregnancy, Hematologic Complications

Definition

The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPregnancy Complications, Hematologic

Professional guidelines

PubMed

TREATMENT OF 300 CASES OF IRON DEFICIENCY OF PREGNANCY BY TOTAL DOSE INFUSION OF IRON-DEXTRAN COMPLEX.
VARDE KN
J Obstet Gynaecol Br Commonw 1964 Dec;71:919-22. doi: 10.1111/j.1471-0528.1964.tb04380.x. PMID: 14243212
LABORATORY DIAGNOSIS OF HEMOLYTIC DISEASE OF THE NEWBORN.
MATHIESON DR
Clin Obstet Gynecol 1964 Dec;10:916-20. doi: 10.1097/00003081-196412000-00003. PMID: 14234044

Recent clinical studies

Etiology

Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Managing ITP and thrombocytopenia in pregnancy.
Eslick R, McLintock C
Platelets 2020;31(3):300-306. Epub 2019 Jul 11 doi: 10.1080/09537104.2019.1640870. PMID: 31296105
Pregnancy and delivery in women with von Willebrand disease.
Castaman G, James PD
Eur J Haematol 2019 Aug;103(2):73-79. Epub 2019 May 31 doi: 10.1111/ejh.13250. PMID: 31107984Free PMC Article
Thrombocytopenia in pregnancy.
Cines DB, Levine LD
Blood 2017 Nov 23;130(21):2271-2277. Epub 2017 Jun 21 doi: 10.1182/blood-2017-05-781971. PMID: 28637667Free PMC Article
Antiphospholipid syndrome.
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Diagnosis

Update on Thrombocytopenia in Pregnancy.
Subtil SFC, Mendes JMB, Areia ALFA, Moura JPAS
Rev Bras Ginecol Obstet 2020 Dec;42(12):834-840. Epub 2020 Dec 21 doi: 10.1055/s-0040-1721350. PMID: 33348401Free PMC Article
Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Managing ITP and thrombocytopenia in pregnancy.
Eslick R, McLintock C
Platelets 2020;31(3):300-306. Epub 2019 Jul 11 doi: 10.1080/09537104.2019.1640870. PMID: 31296105
Thrombocytopenia in pregnancy.
Cines DB, Levine LD
Blood 2017 Nov 23;130(21):2271-2277. Epub 2017 Jun 21 doi: 10.1182/blood-2017-05-781971. PMID: 28637667Free PMC Article
Antiphospholipid syndrome.
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Therapy

Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.
Hamulyák EN, Scheres LJ, Marijnen MC, Goddijn M, Middeldorp S
Cochrane Database Syst Rev 2020 May 2;5(5):CD012852. doi: 10.1002/14651858.CD012852.pub2. PMID: 32358837Free PMC Article
Iron deficiency anemia in pregnancy.
Di Renzo GC, Spano F, Giardina I, Brillo E, Clerici G, Roura LC
Womens Health (Lond) 2015 Nov;11(6):891-900. Epub 2015 Oct 16 doi: 10.2217/whe.15.35. PMID: 26472066
Daily oral iron supplementation during pregnancy.
Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T
Cochrane Database Syst Rev 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. PMID: 26198451Free PMC Article
Nutrition and maternal, neonatal, and child health.
Christian P, Mullany LC, Hurley KM, Katz J, Black RE
Semin Perinatol 2015 Aug;39(5):361-72. Epub 2015 Jul 10 doi: 10.1053/j.semperi.2015.06.009. PMID: 26166560
International consensus report on the investigation and management of primary immune thrombocytopenia.
Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young J, Kuter DJ
Blood 2010 Jan 14;115(2):168-86. Epub 2009 Oct 21 doi: 10.1182/blood-2009-06-225565. PMID: 19846889

Prognosis

Pregnancy and sickle cell disease: an overview of complications and suggested perinatal care.
Moukalled NM, Bou Fakhredin R, Taher AT
Expert Rev Hematol 2022 Dec;15(12):1055-1061. Epub 2022 Nov 28 doi: 10.1080/17474086.2022.2151432. PMID: 36413684
The incidence, complications, and treatment of iron deficiency in pregnancy.
Benson AE, Shatzel JJ, Ryan KS, Hedges MA, Martens K, Aslan JE, Lo JO
Eur J Haematol 2022 Dec;109(6):633-642. Epub 2022 Oct 4 doi: 10.1111/ejh.13870. PMID: 36153674Free PMC Article
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Nutrition and maternal, neonatal, and child health.
Christian P, Mullany LC, Hurley KM, Katz J, Black RE
Semin Perinatol 2015 Aug;39(5):361-72. Epub 2015 Jul 10 doi: 10.1053/j.semperi.2015.06.009. PMID: 26166560
Pregnancy-associated thrombosis.
James AH
Hematology Am Soc Hematol Educ Program 2009:277-85. doi: 10.1182/asheducation-2009.1.277. PMID: 20008211

Clinical prediction guides

How I treat thrombocytopenia in pregnancy.
Fogerty AE, Kuter DJ
Blood 2024 Feb 29;143(9):747-756. doi: 10.1182/blood.2023020726. PMID: 37992219
Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy.
Smith C, Teng F, Branch E, Chu S, Joseph KS
Obstet Gynecol 2019 Dec;134(6):1234-1244. doi: 10.1097/AOG.0000000000003557. PMID: 31764734Free PMC Article
Pregnancy and delivery in women with von Willebrand disease.
Castaman G, James PD
Eur J Haematol 2019 Aug;103(2):73-79. Epub 2019 May 31 doi: 10.1111/ejh.13250. PMID: 31107984Free PMC Article
Antiphospholipid syndrome.
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Anticoagulation therapy.
Ginsberg JA, Crowther MA, White RH, Ortel TL
Hematology Am Soc Hematol Educ Program 2001:339-57. doi: 10.1182/asheducation-2001.1.339. PMID: 11722992

Recent systematic reviews

Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period.
Middleton P, Shepherd E, Gomersall JC
Cochrane Database Syst Rev 2021 Mar 29;3(3):CD001689. doi: 10.1002/14651858.CD001689.pub4. PMID: 33779986Free PMC Article
Iron deficiency anemia in pregnancy in Nigeria-A systematic review.
Ugwu NI, Uneke CJ
Niger J Clin Pract 2020 Jul;23(7):889-896. doi: 10.4103/njcp.njcp_197_19. PMID: 32620715
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.
Hamulyák EN, Scheres LJ, Marijnen MC, Goddijn M, Middeldorp S
Cochrane Database Syst Rev 2020 May 2;5(5):CD012852. doi: 10.1002/14651858.CD012852.pub2. PMID: 32358837Free PMC Article
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Daily oral iron supplementation during pregnancy.
Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T
Cochrane Database Syst Rev 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. PMID: 26198451Free PMC Article

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