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Ectopic pregnancy

MedGen UID:
18618
Concept ID:
C0032987
Pathologic Function
Synonyms: Ectopic Pregnancies; Ectopic Pregnancy; Extrauterine Pregnancies; Extrauterine Pregnancy; Pregnancies, Ectopic; Pregnancies, Extrauterine; Pregnancy, Ectopic; Pregnancy, Extrauterine
SNOMED CT: EP - Ectopic pregnancy (34801009); Ectopic pregnancy (34801009)
 
HPO: HP:0031456
Monarch Initiative: MONDO:0000755

Definition

A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube). [from HPO]

Professional guidelines

PubMed

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
Curry A, Williams T, Penny ML
Am Fam Physician 2019 Sep 15;100(6):357-364. PMID: 31524362

Curated

UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

Recent clinical studies

Etiology

Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295

Diagnosis

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Houser M, Kandalaft N, Khati NJ
Emerg Radiol 2022 Feb;29(1):161-172. Epub 2021 Oct 7 doi: 10.1007/s10140-021-01974-7. PMID: 34618256
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295

Therapy

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Tonick S, Conageski C
Obstet Gynecol Clin North Am 2022 Sep;49(3):537-549. doi: 10.1016/j.ogc.2022.02.018. PMID: 36122984
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Birch Petersen K, Hoffmann E, Rifbjerg Larsen C, Svarre Nielsen H
Fertil Steril 2016 Apr;105(4):958-67. Epub 2016 Jan 18 doi: 10.1016/j.fertnstert.2015.12.130. PMID: 26794422

Prognosis

Heemelaar S, Josef M, Diener Z, Chipeio M, Stekelenburg J, van den Akker T, Mackenzie S
Bull World Health Organ 2020 Aug 1;98(8):548-557. Epub 2020 Jul 1 doi: 10.2471/BLT.20.251371. PMID: 32773900Free PMC Article
Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T
Am J Obstet Gynecol 2020 Apr;222(4):367.e1-367.e22. Epub 2019 Dec 13 doi: 10.1016/j.ajog.2019.10.102. PMID: 31953115
Marion LL, Meeks GR
Clin Obstet Gynecol 2012 Jun;55(2):376-86. doi: 10.1097/GRF.0b013e3182516d7b. PMID: 22510618
Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF
Lancet 2006 Apr 1;367(9516):1066-1074. doi: 10.1016/S0140-6736(06)68397-9. PMID: 16581405
Dasgupta S
J Indian Med Assoc 1995 Feb;93(2):55-7. PMID: 7658038

Clinical prediction guides

Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Deng S, Su X, Li X, Shen X, Chen S, Lin X, Ye M
J Healthc Eng 2022;2022:7797484. Epub 2022 Feb 28 doi: 10.1155/2022/7797484. PMID: 35265305Free PMC Article
Bottomley C, Bourne T
Best Pract Res Clin Obstet Gynaecol 2009 Aug;23(4):463-77. Epub 2009 Jun 6 doi: 10.1016/j.bpobgyn.2009.02.004. PMID: 19502113
Cartwright J, Duncan WC, Critchley HO, Horne AW
Reproduction 2009 Jul;138(1):9-22. Epub 2009 Mar 25 doi: 10.1530/REP-09-0060. PMID: 19321656
Brennan DF
Acad Emerg Med 1995 Dec;2(12):1090-7. doi: 10.1111/j.1553-2712.1995.tb03155.x. PMID: 8597921

Recent systematic reviews

Silva B, Viana Pinto P, Costa MA
Eur J Obstet Gynecol Reprod Biol 2023 Sep;288:36-43. Epub 2023 Jul 1 doi: 10.1016/j.ejogrb.2023.06.030. PMID: 37421745
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM
Cochrane Database Syst Rev 2020 Oct 23;10(10):CD011031. doi: 10.1002/14651858.CD011031.pub3. PMID: 33095458Free PMC Article
Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F, Familiari A, Scambia G, Acharya G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Feb;51(2):169-175. doi: 10.1002/uog.17568. PMID: 28661021
Birch Petersen K, Hoffmann E, Rifbjerg Larsen C, Svarre Nielsen H
Fertil Steril 2016 Apr;105(4):958-67. Epub 2016 Jan 18 doi: 10.1016/j.fertnstert.2015.12.130. PMID: 26794422

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

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