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Amnesia

MedGen UID:
1881
•Concept ID:
C0002622
•
Mental or Behavioral Dysfunction
Synonyms: Amnesia Memory Loss; Amnesia-Memory Loss; Amnesia-Memory Losses; Amnesias
SNOMED CT: Dysmnesia (386807006); LOM - loss of memory (48167000); Memory gone (48167000); Loss of memory (48167000); Amnesia (48167000); Memory loss (48167000)

Definition

Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories. [from NCI]

Professional guidelines

PubMed

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Analysis of Time to Diagnosis and Outcomes Among Adults With Primary Hyperparathyroidism.
Lorenz FJ, Beauchamp-Perez F, Manni A, Chung T, Goldenberg D, Goyal N
JAMA Netw Open 2022 Dec 1;5(12):e2248332. doi: 10.1001/jamanetworkopen.2022.48332. PMID: 36574247Free PMC Article
Sport-Related Concussion Evaluation and Management.
Doperak J, Anderson K, Collins M, Emami K
Clin Sports Med 2019 Oct;38(4):497-511. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.003. PMID: 31472762

Recent clinical studies

Etiology

Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood.
Manwell LA, Tadros M, Ciccarelli TM, Eikelboom R
J Integr Neurosci 2022 Jan 28;21(1):28. doi: 10.31083/j.jin2101028. PMID: 35164464
Transient Global Amnesia.
Sealy D, Tiller RJ, Johnson K
Am Fam Physician 2022 Jan 1;105(1):50-54. PMID: 35029951
Transient global amnesia.
Arena JE, Rabinstein AA
Mayo Clin Proc 2015 Feb;90(2):264-72. doi: 10.1016/j.mayocp.2014.12.001. PMID: 25659242
Post-traumatic amnesia.
Marshman LA, Jakabek D, Hennessy M, Quirk F, Guazzo EP
J Clin Neurosci 2013 Nov;20(11):1475-81. Epub 2013 Jun 20 doi: 10.1016/j.jocn.2012.11.022. PMID: 23791248
Transient amnesic syndromes.
Bartsch T, Butler C
Nat Rev Neurol 2013 Feb;9(2):86-97. Epub 2013 Jan 8 doi: 10.1038/nrneurol.2012.264. PMID: 23296343

Diagnosis

Transient Global Amnesia.
Ropper AH
N Engl J Med 2023 Feb 16;388(7):635-640. doi: 10.1056/NEJMra2213867. PMID: 36791163
Acute-onset amnesia: transient global amnesia and other causes.
Miller TD, Butler CR
Pract Neurol 2022 Jun;22(3):201-208. Epub 2022 May 3 doi: 10.1136/practneurol-2020-002826. PMID: 35504698
Acute amnestic syndromes.
Alessandro L, Ricciardi M, Chaves H, Allegri RF
J Neurol Sci 2020 Jun 15;413:116781. Epub 2020 Mar 18 doi: 10.1016/j.jns.2020.116781. PMID: 32203745
Transient global amnesia.
Arena JE, Rabinstein AA
Mayo Clin Proc 2015 Feb;90(2):264-72. doi: 10.1016/j.mayocp.2014.12.001. PMID: 25659242
Amnesia.
Benson DF
South Med J 1978 Oct;71(10):1221-7, 1231. doi: 10.1097/00007611-197810000-00011. PMID: 360401

Therapy

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT).
Ekstrand J, Fattah C, Persson M, Cheng T, Nordanskog P, Åkeson J, Tingström A, Lindström MB, Nordenskjöld A, Movahed Rad P
Int J Neuropsychopharmacol 2022 May 27;25(5):339-349. doi: 10.1093/ijnp/pyab088. PMID: 35020871Free PMC Article
Pharmacological interventions for agitated behaviours in patients with traumatic brain injury: a systematic review.
Williamson D, Frenette AJ, Burry LD, Perreault M, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F
BMJ Open 2019 Jul 9;9(7):e029604. doi: 10.1136/bmjopen-2019-029604. PMID: 31289093Free PMC Article
Electroconvulsive therapy-induced persistent retrograde amnesia: could it be minimised by ketamine or other pharmacological approaches?
Gregory-Roberts EM, Naismith SL, Cullen KM, Hickie IB
J Affect Disord 2010 Oct;126(1-2):39-45. Epub 2010 Jan 8 doi: 10.1016/j.jad.2009.11.018. PMID: 20060172
Amnesia and crime.
Bourget D, Whitehurst L
J Am Acad Psychiatry Law 2007;35(4):469-80. PMID: 18086739
Preparation, premedication, and surveillance.
Bell GD
Endoscopy 2004 Jan;36(1):23-31. doi: 10.1055/s-2004-814117. PMID: 14722852

Prognosis

Definition and epidemiology of mild traumatic brain injury.
Lefevre-Dognin C, Cogné M, Perdrieau V, Granger A, Heslot C, Azouvi P
Neurochirurgie 2021 May;67(3):218-221. Epub 2020 May 6 doi: 10.1016/j.neuchi.2020.02.002. PMID: 32387427
Ischemic Amnesia: Causes and Outcome.
Michel P, Beaud V, Eskandari A, Maeder P, Demonet JF, Eskioglou E
Stroke 2017 Aug;48(8):2270-2273. Epub 2017 Jun 5 doi: 10.1161/STROKEAHA.117.017420. PMID: 28584000
Anti-LGI1 encephalitis: Clinical syndrome and long-term follow-up.
van Sonderen A, Thijs RD, Coenders EC, Jiskoot LC, Sanchez E, de Bruijn MA, van Coevorden-Hameete MH, Wirtz PW, Schreurs MW, Sillevis Smitt PA, Titulaer MJ
Neurology 2016 Oct 4;87(14):1449-1456. Epub 2016 Sep 2 doi: 10.1212/WNL.0000000000003173. PMID: 27590293
Transient global amnesia.
Marazzi C, Scoditti U, Ticinesi A, Nouvenne A, Pigna F, Guida L, Morelli I, Borghi L, Meschi T
Acta Biomed 2014 Dec 17;85(3):229-35. PMID: 25567459
Retrosplenial amnesia.
Valenstein E, Bowers D, Verfaellie M, Heilman KM, Day A, Watson RT
Brain 1987 Dec;110 ( Pt 6):1631-46. doi: 10.1093/brain/110.6.1631. PMID: 3427404

Clinical prediction guides

Post-concussion syndrome: Still forgotten? From the disappearance of the DSM-5 to a multidisciplinary consultation.
Auxéméry Y, Gayraud F
Encephale 2021 Oct;47(5):491-494. Epub 2020 Nov 18 doi: 10.1016/j.encep.2020.06.017. PMID: 33218667
Screening for confabulations with the confabulation screen.
Dalla Barba G, Brazzarola M, Marangoni S, La Corte V
Neuropsychol Rehabil 2020 Jan;30(1):116-129. Epub 2018 Apr 24 doi: 10.1080/09602011.2018.1464475. PMID: 29688124
Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort.
Liu P, Wu L, Peng G, Han Y, Tang R, Ge J, Zhang L, Jia L, Yue S, Zhou K, Li L, Luo B, Wang B
Brain Behav Immun 2019 Aug;80:633-643. Epub 2019 May 4 doi: 10.1016/j.bbi.2019.05.008. PMID: 31063846
Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia.
Harrison NA, Johnston K, Corno F, Casey SJ, Friedner K, Humphreys K, Jaldow EJ, Pitkanen M, Kopelman MD
Brain 2017 Sep 1;140(9):2498-2510. doi: 10.1093/brain/awx186. PMID: 29050391
Post-traumatic amnesia and confusional state: hazards of retrospective assessment.
Friedland D, Swash M
J Neurol Neurosurg Psychiatry 2016 Oct;87(10):1068-74. Epub 2016 Feb 17 doi: 10.1136/jnnp-2015-312193. PMID: 26888959

Recent systematic reviews

A Systematic Review and Meta-Analysis Investigating Head Trauma in Boxing.
Donnelly RR, Ugbolue UC, Gao Y, Gu Y, Dutheil F, Baker JS
Clin J Sport Med 2023 Nov 1;33(6):658-674. doi: 10.1097/JSM.0000000000001195. PMID: 37862081Free PMC Article
Posttraumatic Amnesia: A Systematic Review and Meta-Analysis. Proposal for a New Severity Classification.
Vile AR, Jang K, Gourlay D, Marshman LAG
World Neurosurg 2022 Jun;162:e369-e393. Epub 2022 Mar 11 doi: 10.1016/j.wneu.2022.03.018. PMID: 35288355
Post-concussive Signs and Symptoms in Preschool Children: A Systematic Review.
Yumul JN, Crowe L, Catroppa C, Anderson V, McKinlay A
Neuropsychol Rev 2022 Sep;32(3):631-650. Epub 2021 Aug 14 doi: 10.1007/s11065-021-09518-z. PMID: 34390464
Pharmacological interventions for agitated behaviours in patients with traumatic brain injury: a systematic review.
Williamson D, Frenette AJ, Burry LD, Perreault M, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F
BMJ Open 2019 Jul 9;9(7):e029604. doi: 10.1136/bmjopen-2019-029604. PMID: 31289093Free PMC Article
Anesthetic management during cardiopulmonary bypass: a systematic review.
Barry AE, Chaney MA, London MJ
Anesth Analg 2015 Apr;120(4):749-69. doi: 10.1213/ANE.0000000000000612. PMID: 25790208

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