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Anemia due to Disorder of Glutathione Metabolism

MedGen UID:
1921
•Concept ID:
C0002899
•
Disease or Syndrome

Definition

Anemia resulting from an abnormality of glutathione deficiency. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnemia due to Disorder of Glutathione Metabolism

Professional guidelines

PubMed

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives.
Garcia AA, Koperniku A, Ferreira JCB, Mochly-Rosen D
Trends Pharmacol Sci 2021 Oct;42(10):829-844. Epub 2021 Aug 10 doi: 10.1016/j.tips.2021.07.002. PMID: 34389161Free PMC Article
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Pagano G, Talamanca AA, Castello G, Pallardó FV, Zatterale A, Degan P
Biol Chem 2012 Jan;393(1-2):11-21. doi: 10.1515/BC-2011-227. PMID: 22628295
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Recent clinical studies

Etiology

Maternal malnutrition and anaemia in India: dysregulations leading to the 'thin-fat' phenotype in newborns.
Pandit P, Galande S, Iris F
J Nutr Sci 2021;10:e91. Epub 2021 Oct 11 doi: 10.1017/jns.2021.83. PMID: 34733503Free PMC Article
Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism.
Kožich V, Stabler S
J Nutr 2020 Oct 1;150(Suppl 1):2506S-2517S. doi: 10.1093/jn/nxaa134. PMID: 33000152
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE
Nat Commun 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. PMID: 32286299Free PMC Article
Glutathione synthetase deficiency.
Njålsson R
Cell Mol Life Sci 2005 Sep;62(17):1938-45. doi: 10.1007/s00018-005-5163-7. PMID: 15990954Free PMC Article
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Diagnosis

Oxidative Stress and DNA Damage Markers in Colorectal Cancer.
Acevedo-León D, Monzó-Beltrán L, Pérez-Sánchez L, Naranjo-Morillo E, Gómez-Abril SÁ, Estañ-Capell N, Bañuls C, Sáez G
Int J Mol Sci 2022 Oct 1;23(19) doi: 10.3390/ijms231911664. PMID: 36232966Free PMC Article
Amniotic fluid metabolomic and lipidomic alterations associated with hemoglobin Bart's diseases.
Chen X, Chen H, Nie H, Li G, Su J, Cao X, Cao Y, Wei F
Metabolomics 2021 Sep 6;17(9):82. doi: 10.1007/s11306-021-01834-y. PMID: 34490587
Reduced glutathione and glutathione disulfide in the blood of glucose-6-phosphate dehydrogenase-deficient newborns.
Gong ZH, Tian GL, Huang QW, Wang YM, Xu HP
BMC Pediatr 2017 Jul 20;17(1):172. doi: 10.1186/s12887-017-0920-y. PMID: 28728551Free PMC Article
Inborn errors in the metabolism of glutathione.
Ristoff E, Larsson A
Orphanet J Rare Dis 2007 Mar 30;2:16. doi: 10.1186/1750-1172-2-16. PMID: 17397529Free PMC Article
Glutathione synthetase deficiency.
Njålsson R
Cell Mol Life Sci 2005 Sep;62(17):1938-45. doi: 10.1007/s00018-005-5163-7. PMID: 15990954Free PMC Article

Therapy

L-glutamine for sickle cell disease: more than reducing redox.
Jafri F, Seong G, Jang T, Cimpeanu E, Poplawska M, Dutta D, Lim SH
Ann Hematol 2022 Aug;101(8):1645-1654. Epub 2022 May 14 doi: 10.1007/s00277-022-04867-y. PMID: 35568758
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE
Nat Commun 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. PMID: 32286299Free PMC Article
L-glutamine for sickle cell disease: Knight or pawn?
Sadaf A, Quinn CT
Exp Biol Med (Maywood) 2020 Jan;245(2):146-154. Epub 2020 Jan 27 doi: 10.1177/1535370219900637. PMID: 31985279Free PMC Article
Role of Zinc Supplementation on Ischemia/Reperfusion Injury in Various Organs.
Akbari G
Biol Trace Elem Res 2020 Jul;196(1):1-9. Epub 2019 Dec 11 doi: 10.1007/s12011-019-01892-3. PMID: 31828721
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
Yardley-Jones A, Anderson D, Parke DV
Br J Ind Med 1991 Jul;48(7):437-44. doi: 10.1136/oem.48.7.437. PMID: 1854646Free PMC Article

Prognosis

MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.
Wang H, You X, Wang J, Chen X, Gao Y, Wang M, Zhang W, Zhang J, Yu Y, Han B, Qi M, Liu X, Lou H, Dong T
Nat Commun 2024 Sep 19;15(1):8226. doi: 10.1038/s41467-024-52537-6. PMID: 39300060Free PMC Article
GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.
Ferracini AC, Lopes-Aguiar L, Lourenço GJ, Yoshida A, Lima CSP, Sarian LO, Derchain S, Kroetz DL, Mazzola PG
Clin Transl Sci 2021 Mar;14(2):720-728. Epub 2020 Dec 16 doi: 10.1111/cts.12937. PMID: 33326171Free PMC Article
Methods Employed in Cytofluorometric Assessment of Eryptosis, the Suicidal Erythrocyte Death.
Jemaà M, Fezai M, Bissinger R, Lang F
Cell Physiol Biochem 2017;43(2):431-444. Epub 2017 Sep 1 doi: 10.1159/000480469. PMID: 28922657
Genetic polymorphisms of glutathione-S-transferase and microsomal epoxide hydrolase in egyptian acquired aplastic anemia patients.
Youssry I, Hammoud R, Ibrahim O, Youssef M, Beshlawy A
J Pediatr Hematol Oncol 2011 Mar;33(2):89-92. doi: 10.1097/MPH.0b013e3181ff78ce. PMID: 21228718
Inborn errors in the metabolism of glutathione.
Ristoff E, Larsson A
Orphanet J Rare Dis 2007 Mar 30;2:16. doi: 10.1186/1750-1172-2-16. PMID: 17397529Free PMC Article

Clinical prediction guides

MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.
Wang H, You X, Wang J, Chen X, Gao Y, Wang M, Zhang W, Zhang J, Yu Y, Han B, Qi M, Liu X, Lou H, Dong T
Nat Commun 2024 Sep 19;15(1):8226. doi: 10.1038/s41467-024-52537-6. PMID: 39300060Free PMC Article
The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency.
Kontoghiorghes GJ
Int J Mol Sci 2024 Apr 25;25(9) doi: 10.3390/ijms25094654. PMID: 38731873Free PMC Article
Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients.
Tomás-Simó P, D'Marco L, Romero-Parra M, Tormos-Muñoz MC, Sáez G, Torregrosa I, Estañ-Capell N, Miguel A, Gorriz JL, Puchades MJ
Int J Environ Res Public Health 2021 Jul 23;18(15) doi: 10.3390/ijerph18157806. PMID: 34360098Free PMC Article
GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.
Ferracini AC, Lopes-Aguiar L, Lourenço GJ, Yoshida A, Lima CSP, Sarian LO, Derchain S, Kroetz DL, Mazzola PG
Clin Transl Sci 2021 Mar;14(2):720-728. Epub 2020 Dec 16 doi: 10.1111/cts.12937. PMID: 33326171Free PMC Article
Inborn errors in the metabolism of glutathione.
Ristoff E, Larsson A
Orphanet J Rare Dis 2007 Mar 30;2:16. doi: 10.1186/1750-1172-2-16. PMID: 17397529Free PMC Article

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